Abstract：
:Although a peripheral neuropathy is the best known neurological complication of Waldenstrom's Macroglobulinemia (WM), the association of Amyotrophic Lateral Sclerosis (ALS), or other Motor Neuron Diseases (MND) with monoclonal gammopathies is described. We report the case of a male patient (41 years old) with WM and ALS. Whether monoclonal gammopathies play a role in the pathogenesis of MND is unclear but is la possible that patients might have antibodies against motor neurons. In our reported case neurologic symptoms were the first and the most important manifestations of the underlying hemopathy and despite plasmapheresis and immunosuppressive treatment ALS syndrome progressed. The neurologic disease worsened despite the improvement of WM.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Vannucci P,Castiglioni M,Filidei M,Riccioni Nsubject
Has Abstractpub_date
1997-04-01 00:00:00pages
167-70issue
4eissn
0026-4806issn
1827-1669journal_volume
88pub_type
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