Established and emerging therapies for hepatocellular carcinoma.

Abstract:

:Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver with a worldwide increasing incidence. The incidence of HCC is closely related to the epidemiology of the risk factors which are mainly represented by chronic viral hepatitis B and C. Obesity and type II diabetes, often associated with chronic nonalcoholic fatty liver disease, are emerging independent risk factors for HCC development. Although the risk factors for HCC are well characterized, the molecular mechanisms responsible for malignant transformation of hepatocytes are not well understood. HCC diagnosis and therapy follow defined algorithms according to the European Association for the Study of the Liver and the American Association for the Study of Liver Diseases guidelines. Liver transplantation has been shown the best outcome for selected patients with early tumor stage but its application is limited by the shortage of liver grafts. After hepatic resection prognosis remains unsatisfactory due to a high incidence of tumor recurrence. Selective internal radiation therapy is emerging as promising loco-regional treatment for patients with advanced HCC having good performance status and liver reserve but not amenable to surgery. The recently introduced orally active multikinase inhibitor sorafenib has been established as palliative systemic therapy. Further improved understanding of molecular mechanisms underlying HCC development will facilitate the development of new targeted therapeutic strategies.

journal_name

Minerva Med

journal_title

Minerva medica

authors

Cicinnati VR,Sotiropoulos GC,Beckebaum S

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

405-18

issue

6

eissn

0026-4806

issn

1827-1669

pii

R10113113

journal_volume

101

pub_type

杂志文章,评审
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    pub_type: 杂志文章

    doi:

    authors: Vizzini GM

    更新日期:1976-04-28 00:00:00

  • [Review of 87 cases of scoliosis surgically treated].

    abstract:BACKGROUND:The authors compared the results and complications in surgical treatment of idiopathic scoliosis with Harrington's rod instrumentation with subtrasversal wires in dorsal treat. METHODS:A research on 87 cases operated on for idiopathic scoliosis from 1987 to 1995 is carried out. The 87 cases include 65 femal...

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    doi:

    authors: Costanzo G,Savi Scarponi F,Fricano C

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  • [Diagnostic value and therapeutic limits of endoscopic polypectomy of the stomach].

    abstract::Digestive endoscopy represents the current therapy of the gastric polyps. These lesions are endoscopically found in an unexpected number of patients, because of the frequent failure of radiology by itself. Furthermore endoscopic radical polypectomy is mostly possible for the inflammatory and adenomatous polyps. Otherw...

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    doi:

    authors: Franzini M,Piscioli F,Sgarbi G,Bronzoni S,Lucchini A

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  • [Adenopathies in chronic myeloid leukemia (CML). Study of 161 cases].

    abstract::161 cases of CML have been studied. Clinically significant adenopathies were present in 3,2% of the patients at the moment of diagnosis, and in the subsequent course they appeared in 7% of them. The behaviour of adenopathies showed to be unrelated to: --splenomegaly; --blastic metamorphosis in the peripheral blood or ...

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    pub_type: 杂志文章

    doi:

    authors: Paolino W,Infelise V,Degani G,Falda M,Paolino F,Fiorio C,Marmont F,Coda R

    更新日期:1980-08-25 00:00:00

  • [Diffuse liver diseases: possibility or limitations of echography?].

    abstract::Reports on echography as a diagnostic tool in diffused liver diseases are quite numerous in the literature. As it is shown by the analysis of such reports there is no general agreement as far as including echography into the diagnostic protocol of liver diseases is concerned. Reliability of echography for the assessme...

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    pub_type: 杂志文章

    doi:

    authors: Lagalla R,Calabrese G,Bennici E

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  • Endoscopic ultrasound and fine needle aspiration in inflammatory and cystic pancreatic pathology.

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    pub_type: 杂志文章,评审

    doi:

    authors: Vazquez-Sequeiros E

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  • [A left atrial myxoma. The clinical aspects].

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    pub_type: 杂志文章

    doi:

    authors: Tomassini B,Torta D,Bobba F,Albano T

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  • [The clinico-immunological surveillance of neurofibromatosis].

    abstract::Considering the more recent physiopathogenetic advancements in neurofibromatosis (NF), we propose to employ novel instrumental and laboratory procedures for the immunological and clinical surveillance of NF. In NF the evolution of the non-self can lead to disease expansion, at times transforming into malignancy. Conte...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Gerosa P,Vai C,Canepari C,Fontana A,Bizzozero L,Giussani G,Spinelli M

    更新日期:1994-05-01 00:00:00

  • [Doping and sports].

    abstract::Doping is widely known as the use of banned substances and practices by athletes in an attempt to improve sporting performances. The term doping likely derives from "dope", an ancient expression referred to a primitive alcoholic drink that was used as a stimulant in South African ceremonial dances; gradually, the term...

    journal_title:Minerva medica

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Lippi G,Guidi G

    更新日期:1999-09-01 00:00:00

  • [Daily secretion of parathyroid hormone in adult subjects].

    abstract::Data reported in the literature on the existence of a circadian rhythm in PTH secretion are contradictory. In order to assess whether haematic PTH levels vary over a 24 hour period, the plasma levels of the hormone were evaluated at 6 different times during the day (12, 19, 24, 2, 4, 6 hours) in a group of 10 healthy ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Mauri R,Resentini M,Lissoni P,Mascherpa GF,Proietti Ricci D,Morabito F

    更新日期:1985-06-30 00:00:00

  • A comparative study on clinical features of anterior ischemic optic neuropathy and idiopathic optic neuritis.

    abstract:: ...

    journal_title:Minerva medica

    pub_type: 信件

    doi:10.23736/S0026-4806.19.05976-7

    authors: Xie Y,Yang X,Zhang W,Zhao W

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  • [Use of radioactive isotopes in the diagnosis of pulmonary tumors. Analysis of the results of 18 anatomically verified cases].

    abstract::18 cases of anatomically verified lung cancer were studied scintigraphically with microspheres of human albumin labelled with 99Tc, mercury bichloride (197Hg) and citrate of gallium (67Ga), to assess the diagnostic value of this technique. Using albumin microspheres, changes in the scintigraphic picture were obtained ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Bergonzi M,Foresti V

    更新日期:1976-10-27 00:00:00

  • [A heparin-glucuronylglucosaminoglycan combination for topical use. An evaluation of the therapeutic effects in induced experimental muscle damage and in minor sports injuries].

    abstract::The aim of the study was to evaluate the clinical efficacy of the association of heparin and sulodexide on experimental pain and on "small sport traumatology". In the experimental part of the study, cutaneous pain threshold and subcutaneous tissue ticking were measured after the induction of an algogenic focus in deep...

    journal_title:Minerva medica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Dragani L,Colozzi A,Schiavone C,Obletter G,Celiberti V,Radico S,Vecchiet L

    更新日期:1989-04-01 00:00:00

  • Emerging trends in cardiovascular research: HFpEF in the spotlight. A bibliometric analysis of the years 2009-2016.

    abstract:BACKGROUND:Up to 50% of patients suffering from acute decompensated heart failure show normal or slightly reduced left ventricular ejection fraction (LVEF). This syndrome, which is known as "heart failure with preserved ejection fraction" (HFpEF) is associated with increasing age. Epidemiological studies could portrait...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:10.23736/S0026-4806.20.06447-2

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  • [Mortality from malignant tumors in residents of the city of Verona in 1980].

    abstract::Malignant tumours mortality among residents of the city of Verona (267,703 at 31-12-1980) during the year 1980 is assessed from the ISTAT individual death cards and/or municipal death certificates (especially in the case of deaths outside the municipality). The figures are broken down by site, apparatus or system (in ...

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    pub_type: 杂志文章

    doi:

    authors: Merler E,Carnevale F,Rebesan F,Ricci P,Geddes M,Fiore-Donati L

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  • [Double-blind study of the bronchodilating action of the aminophylline-clenbuterol combination in asthmatic patients].

    abstract::The results obtained with the administration of aminophylline and clenbuterol either separately or in association, to a group of patients with chronic obstructive bronchopneumopathies are reported. The two drugs had a more or less identical broncho-dilatory effect with the beta 2-stimulant acting earlier but for a sho...

    journal_title:Minerva medica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Osella D,Giorgis GE,Galietti F,Miravalle C,Ardizzi A

    更新日期:1986-04-21 00:00:00

  • [Correlation between the number of sessions and therapeutical effect in patients suffering from low back pain treated with acupuncture: a randomized controlled blind study].

    abstract:AIM:The aim of this study is to verify the therapeutical effect of acupuncture reflexotherapy in low back pain treatment and to test if the number of sessions could influence the results at the end of therapy. METHODS:Thirty-one patients, suffering from low back pain, were randomly divided into 2 groups: the first gro...

    journal_title:Minerva medica

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ceccherelli F,Gagliardi G,Barbagli P,Caravello M

    更新日期:2003-08-01 00:00:00

  • [Analysis of surgical treatment of 592 cases of cancer of the stomach].

    abstract::A series of 592 cases of gastric carcinoma operated on between January 1960 and December 1974 at the S. Croce Hospital at Cuneo is reported. The following observations were made: greater frequency in males (68.25%). The following localizations: cardiac portion 31 cases; fundus 20; body 93 and antropyloric 249. Cancer ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Cartia Q,Quaranta L,Lucarini L,Galgano E

    更新日期:1977-05-05 00:00:00

  • [Combination antimetabolite-alkylating agent-vinblastine in the treatment of advanced breast cancer].

    abstract::The results obtained in 14 patients suffering from hormone-resistant metastatic breast cancer treated with the following association: methotrexate (5-fluorouracyl in case of methotrexate intolerance), cyclophosphamide, vinblastin administered i.v. once every 10-13 days, are reported. 4 objective regression (29%) were ...

    journal_title:Minerva medica

    pub_type: 临床试验,杂志文章

    doi:

    authors: Pipino G,Germiniani R,Lavorato F

    更新日期:1977-03-17 00:00:00

  • [Blastic cytophagocytosis in acute leukosis].

    abstract::The phagocytic activity of the blastic cells in the course of acute leukemias has been previously analyzed mainly by means of technical methods concerning the ingestion of inactive particles or foreign bodies. The spontaneous ingestion of cells (cytophagocytosis) has been studied to a minor extent, with reference to s...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Castoldi GL

    更新日期:1978-04-14 00:00:00

  • [Cases of enuresis nocturna treated with single reflexotherapy. Clinical and therapeutic evaluation].

    abstract::Treatment of children with nocturnal enuresis by means of acupuncture, auriculotherapy, etc. is reported. The aetiopathogenetic background, the results of treatment, and the neurophysiological mechanisms through which the action of reflexotherapy can be explained are discussed. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Milani L

    更新日期:1976-11-24 00:00:00

  • [Usefulness of the determination of CA 19-9 in the follow-up of patients with gastroenteric neoplasms in comparison to CEA].

    abstract::28 cases of carcinoma of the digestive tract were studied in order to assess the value of assaying a new tumour marker (CA 19-9) on monitoring the postoperative course of neoplasia. CEA, a tumour antigen of more certain dependability was assayed at the same time. In the case series examined it was found useful to moni...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Pecchio F,Piantino P,Oliaro A,Rapellino M,Ricci E,Aimo G,Obert R

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  • [Scintigraphy of the bile ducts by means of the Tc-99m-acid N-(2,6 diethyl-acetanilide) iminodiacetic acid in pediatrics].

    abstract::Results with diethyl-IDA in the diagnosis of dilatation and obstruction of the bile ducts are reported. By comparison with methyl-IDA, the more rapid blood clearance and slower renal excretion of diethyl-IDA do not lead to interference on the part of the right kidney and ureter during the first 30' of scintiscanning. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Mussa GC,Bona G,Silvestro L

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  • [Peculiar clinical pictures of Guillain-Barré-Strohl syndrome. Description of 2 clinical cases].

    abstract::A clinical of 37 patients suffering form Guillain-Baré syndrome has been carried out. Because of their unusual onset and clinical course, two of the cases are reported in full. The first case presented atypical onset modalities characterised by dysarthria, dysphonia and dysphagia with subsequent diplegia of the facial...

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    pub_type: 杂志文章

    doi:

    authors: Appiotti A,Trebini F,Scarzella G

    更新日期:1990-10-01 00:00:00

  • [Study of 4 cases of chronic subdural hematoma with unusual symptomatology].

    abstract::Some cases of chronic subdural haematomas (in patients aged from 17 to 27 years) with unusual symptomatology and difficult diagnosis are presented. The usefulness of cerebral scintigraphy which can clarify any diagnostic doubt and lead to a right neuroradiological behaviour is underlined. ...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Bellotti C,Formaggio G,Regalia F,Sacerdote I

    更新日期:1975-10-10 00:00:00

  • [Prognostic value of the ratio of bone marrow plasma cells in multiple myeloma].

    abstract::The relationship between initial percentage of bone marrow plasma cells and survival was studied in a group of 70 patients affected with multiple myeloma. All patients had a complete follow-up. The initial percentage of plasma cells shows a highly significant correlation with survival. Moreover, the percentage of bone...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Pasqualetti P,Colantonio D,Casale R

    更新日期:1990-03-01 00:00:00

  • [Spectrophotofluorimetric enzymatic determination of total serum bile acids].

    abstract::A new enzymatic fluorimetric assay for the determination of total serum bile acids is described. The enzyme 3 alpha-idroxysteroid NAD oxireductase by oxydising the free OH in position 3 alpha of bile acid molecule, reduce NAD previously added. Afterwards the hydrogen of the generated NADH is transferred by a diaphoras...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Annoni G,Barbi G,Benzio G

    更新日期:1980-02-25 00:00:00

  • [Therapy of arterial hypertension in diabetic patients. When to start the treatment and which drugs to use?].

    abstract::In this review, the Authors analyzes the more recent data in the Literature about the major cardiovascular risks in diabetic patients affected by systemic arterial hypertension. The more effective pharmacological and not pharmacological treatment is suggested. Particularly the advantages and more important side-effect...

    journal_title:Minerva medica

    pub_type: 杂志文章,评审

    doi:

    authors: Romanò M,Baldini MR

    更新日期:1992-11-01 00:00:00

  • [Cleft palate surgery from its beginnings until today].

    abstract::The Authors have studied the evolution of the cleft palate's surgery, illness known from ancient times, but without any therapeutic solution for a long time. After the discovery of America, with the presence of a new syphilitic infection, cleft palate was generally considered as a consequence of syphilis, and undoubte...

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    pub_type: 历史文章,杂志文章

    doi:

    authors: Zigiotti GL,Messerotti GF,Cavaliere F

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  • Efficacy and tolerability of ketoprofen 200 mg controlled-release cps vs indomethacin 50 mg cps in patients with symptomatic hip osteoarthritis. A multicentre study.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Marcolongo R,Canesi B,Ferri S,Oriente P,Perpignano G,Serni U,Tirri G,Trotta F,Dal Prà A,Lucchini M

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