Abstract:
OBJECTIVE:To quantitate the relief of intractable cancer pain by the use of intraventricular morphine administration. METHODS:Intraventricular morphine administration was performed through an Ommaya reservoir. An initial dose of 0.25 mg of morphine sulfate per 24 hours was administered to all of the patients. This dose was progressively increased in 0.25-mg increments until optimal analgesia was attained. RESULTS:Sixty men and 30 women with a median age of 58 years (range, 23-80 yr) entered the study. The median duration of pain was 6 months (range, 0.5-120 mo). A daily morphine dose of up to 1 mg was adequate to achieve an analgesic effect in 77% of the patients. Only nine patients (10%) achieved < 50% pain relief. Using a multiple regression analysis, only the morphine dosage was found to be an independent prognostic factor. The most frequent side effect (22%) was nausea/vomiting. Also, there were two patients with opioid intolerance and two with intracerebral hematomas. Three reservoirs failed. CONCLUSION:Intraventricular morphine administration is a useful method for palliation of intractable cancer pain.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Karavelis A,Foroglou G,Selviaridis P,Fountzilas Gdoi
10.1097/00006123-199607000-00012subject
Has Abstractpub_date
1996-07-01 00:00:00pages
57-61; discussion 61-2issue
1eissn
0148-396Xissn
1524-4040journal_volume
39pub_type
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