Intraventricular administration of morphine for control of intractable cancer pain in 90 patients.

Abstract:

OBJECTIVE:To quantitate the relief of intractable cancer pain by the use of intraventricular morphine administration. METHODS:Intraventricular morphine administration was performed through an Ommaya reservoir. An initial dose of 0.25 mg of morphine sulfate per 24 hours was administered to all of the patients. This dose was progressively increased in 0.25-mg increments until optimal analgesia was attained. RESULTS:Sixty men and 30 women with a median age of 58 years (range, 23-80 yr) entered the study. The median duration of pain was 6 months (range, 0.5-120 mo). A daily morphine dose of up to 1 mg was adequate to achieve an analgesic effect in 77% of the patients. Only nine patients (10%) achieved < 50% pain relief. Using a multiple regression analysis, only the morphine dosage was found to be an independent prognostic factor. The most frequent side effect (22%) was nausea/vomiting. Also, there were two patients with opioid intolerance and two with intracerebral hematomas. Three reservoirs failed. CONCLUSION:Intraventricular morphine administration is a useful method for palliation of intractable cancer pain.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Karavelis A,Foroglou G,Selviaridis P,Fountzilas G

doi

10.1097/00006123-199607000-00012

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

57-61; discussion 61-2

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

39

pub_type

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