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Relationship between tissue ischemia and venous endothelin-1 during abdominal aortic aneurysm surgery.

Abstract：

OBJECTIVES:Several substances may be released from ischemic tissues with the declamping shock that occurs during abdominal aortic aneurysm surgery. To clarify the relationship between tissue ischemia and venous endothelin-1 (ET-1) level in humans, plasma ET-1 and oxygen content in the iliac vein were measured before anesthesia, after the induction of anesthesia, after the release of the proximal and first distal clamps, after the release of the second distal clamp, and 1 hour after the second clamping. DESIGN:Prospective study. SETTING:A University hospital. PARTICIPANTS:Seven patients who underwent abdominal aneurysmectomy and replacement with bifurcated graft. INTERVENTIONS:A 20G catheter was inserted into the radial artery for the direct measurement of blood pressure and for collecting arterial blood. An 18G, 20-cm catheter was inserted into the femoral vein for collecting venous blood from the lower extremities. MEASUREMENTS AND MAIN RESULTS:The arterial and venous ET-1 levels did not change after the induction of anesthesia. Immediately after the initial release of the proximal and distal clamps, venous oxygen content dramatically decreased from 11.3 to 3.6 mL/dL (vol%) with significant increases in venous ET-1 concentration from 2.3 to 4.9 pg/mL. Concomitant with the decrease in venous oxygen content, venous plasma pH and base excess decreased with increase in PCO2, suggesting that ischemic changes in tissues distal to the cross-clamp may occur during aortic clamping. Venous ET-1 levels were significantly correlated with venous oxygen content, pH, PO2, oxygen saturation, base excess, blood sodium concentration, and potassium concentration. One hour after the second declamping, the venous ET-1 level remained high in comparison with the preanesthetic level, whereas the venous oxygen content returned to the preanesthetic level. There was no correlation between venous plasma ET-1 and venous plasma norepinephrine or epinephrine concentration. CONCLUSIONS:Tissue ischemia may increase venous ET-1 levels in humans. Factor(s) other than tissue ischemia may provoke the increase in venous ET-1 that occurs after the release of the second distal clamp.

journal_name

J Cardiothorac Vasc Anesth

journal_title

Journal of cardiothoracic and vascular anesthesia

authors

Fukuda S,Taga K,Tanaka T,Sakuma K,Fujiwara N,Shimoji K,Fujihara H

doi

10.1016/s1053-0770(05)80132-6

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

510-4

issue

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(05)80132-6

journal_volume

pub_type

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Relationship between tissue ischemia and venous endothelin-1 during abdominal aortic aneurysm surgery.