Enzyme activity of glucose-6-phosphate dehydrogenase-deficient Malaysian neonates during the first 10 days of life.

Abstract:

OBJECTIVE:The objective of this study was to determine the degree of severity of enzyme deficiency in glucose-6-phosphate dehydrogenase (G6PD)-deficient Malaysian neonates as part of an effort to identify risk factors associated with severe hyperbilirubinaemia in G6PD-deficient infants. METHODOLOGY:During this study, enzyme activity was measured in 53/59 (89.8%) hospital-diagnosed G6PD-deficient neonates (34 Malays, 12 Chinese, and seven other ethnic groups) born consecutively in the Kuala Lumpur Maternity Hospital. All neonates, except one, were males. RESULTS:The mean level of enzyme activity of the 52 males G6PD-deficient neonates (0.47 iu/g Hb, 95% confidence intervals: 0.37, 0.57) was less than 10% of that of normal Malaysian male neonates. The enzyme activity of the only female G6PD-deficient infant, at 1.11 iu/g Hb, was 12.5% of the mean G6PD enzyme activity of normal females. CONCLUSION:Our results showed that G6PD deficiency in Malaysian neonates predominantly affects males and is usually severe.

authors

Boo NY,Ainoon O,Arif ZA,Cheong SK,Haliza MS

doi

10.1111/j.1440-1754.1995.tb02912.x

subject

Has Abstract

pub_date

1995-02-01 00:00:00

pages

44-6

issue

1

eissn

1034-4810

issn

1440-1754

journal_volume

31

pub_type

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