The role of inflammation in lumbar pain.

Abstract:

:The clinical features of many cases of low back pain is inadequately explained by anatomic abnormalities alone. A pathophysiologic mechanism that includes a combination of mechanical and biochemical factors is an alternative explanation that is accompanied by less paradox than a purely structural paradigm. A potential unifying feature includes inflammation of neural elements caused by the chemical components of the intervertebral disc. There is a historical basis to the concept of an immunologic potential of the lumbar disc. No discrete in situ evidence or discrete mechanism has been previously identified. The recent demonstration of immunohistopathologic evidence of an immunocompetent cellular response at the epidural interface of lumbar HNPs supports the concept of the immunogenic capacity of nucleus pulposus. The identification of high levels of an inflammatory enzyme, phospholipase A2, in lumbar herniated and degenerative discs presents the basis for a direct inflammogenic capability of lumbar discs, separate from a immunologic mechanism. Subsequent experimental findings of conduction block and perineural inflammation as a consequence of extrathecal application of autologous nucleus pulposus and axonal injury after animal nerve injection of the human disc phospholipase A2 further validates this concept. There is a strong theoretic basis to support the concept that the clinical features of many lumbar disc patients may be explained by inflammation caused by biochemical factors alone or combined with mechanical deformation of lumbar tissues, rather than mechanical factors alone.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Saal JS

doi

10.1097/00007632-199508150-00013

subject

Has Abstract

pub_date

1995-08-15 00:00:00

pages

1821-7

issue

16

eissn

0362-2436

issn

1528-1159

journal_volume

20

pub_type

杂志文章,评审

相关文献

SPINE文献大全
  • Does long-term compressive loading on the intervertebral disc cause degeneration?

    abstract:STUDY DESIGN:Coil springs were stretched and attached to produce a compressive force across the lumbar intervertebral discs of dogs for up to 53 weeks. OBJECTIVE:To test the hypothesis that compressive forces applied to the intervertebral disc for a long period of time cause disc degeneration in vivo in a dog model. ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200012010-00006

    authors: Hutton WC,Ganey TM,Elmer WA,Kozlowska E,Ugbo JL,Doh ES,Whitesides TE Jr

    更新日期:2000-12-01 00:00:00

  • Rapid improvement of paraplegia caused by epidural involvements of Burkitt's lymphoma with chemotherapy.

    abstract:STUDY DESIGN:Case report. OBJECTIVE:The authors present a case of atypical Burkitt's lymphoma with multiple epidural involvements. SUMMARY OF BACKGROUND DATA:Spinal cord compression in children is an emergency that requires urgent attention to minimize neurologic dysfunction. Although it is not life-threatening in mo...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000105540.76773.9C

    authors: Matsubara H,Watanabe K,Sakai H,Chang H,Fujino H,Higashi Y,Kobayashi M,Adachi S,Seto S,Nakahata T

    更新日期:2004-01-01 00:00:00

  • Operative versus nonoperative treatment of leg pain in adults with scoliosis: a retrospective review of a prospective multicenter database with two-year follow-up.

    abstract:STUDY DESIGN:Retrospective review of a prospective, multicenter study. OBJECTIVE:The purpose of this study was to assess the prevalence and severity of leg pain in adults with scoliosis and to assess whether surgery significantly improved leg pain compared with nonoperative management. SUMMARY OF BACKGROUND DATA:Pati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181ac5fcd

    authors: Smith JS,Shaffrey CI,Berven S,Glassman S,Hamill C,Horton W,Ondra S,Schwab F,Shainline M,Fu KM,Bridwell K,Spinal Deformity Study Group.

    更新日期:2009-07-15 00:00:00

  • Repair of vertebral artery injury during anterior cervical decompression.

    abstract:METHODS:Vertebral artery injury is a rarely described complication of anterior cervical decompression. The authors performed a retrospective review of their operative database for the purposes of defining the optimal management of this complication and its avoidance. RESULTS:Four of 1,215 (0.3%) patients undergoing an...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199411001-00010

    authors: Golfinos JG,Dickman CA,Zabramski JM,Sonntag VK,Spetzler RF

    更新日期:1994-11-15 00:00:00

  • Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.

    abstract:STUDY DESIGN:Changes in expression of voltage-dependent ion channel subunits were examined in the radicular pain state. Furthermore, antinociceptive effects of gabapentin on radicular pain were compared with effects on peripheral neuropathic pain. OBJECTIVES:To clarify molecular substrates involved in the development ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200207150-00007

    authors: Abe M,Kurihara T,Han W,Shinomiya K,Tanabe T

    更新日期:2002-07-15 00:00:00

  • The Association Between Patient Reported Outcomes of Spinal Surgery and Societal Costs: A Register Based Study.

    abstract:STUDY DESIGN:Retrospective register-based study using Swedish registers and data prospectively collected in quality register Swespine. OBJECTIVE:Analyze the association of societal costs and spine surgery outcome in low back pain (LBP) patients based on patient reported outcome measures (PROMs). SUMMARY OF BACKGROUND...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003050

    authors: Hansson-Hedblom A,Jonsson E,Fritzell P,Hägg O,Borgström F

    更新日期:2019-09-01 00:00:00

  • The effect of fear of movement beliefs on pain and disability after surgery for lumbar and cervical degenerative conditions.

    abstract:STUDY DESIGN:Prospective cohort study. OBJECTIVE:To examine differences between preoperative and postoperative fear of movement and investigate the relationship between fear of movement and pain, disability and physical health after spinal surgery for degenerative conditions. SUMMARY OF BACKGROUND DATA:Consistent evi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181f8c6f4

    authors: Archer KR,Wegener ST,Seebach C,Song Y,Skolasky RL,Thornton C,Khanna AJ,Riley LH 3rd

    更新日期:2011-09-01 00:00:00

  • Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA:Results of studies analyzing the impact of smoking on complication and pseudarthr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000527

    authors: Bydon M,De la Garza-Ramos R,Abt NB,Gokaslan ZL,Wolinsky JP,Sciubba DM,Bydon A,Witham TF

    更新日期:2014-10-01 00:00:00

  • Changes in surface and radiographic deformity after Universal Spine System for right thoracic adolescent idiopathic scoliosis: is rib-hump reassertion a mechanical problem of the thoracic cage rather than an effect of relative anterior spinal overgrowth?

    abstract:STUDY DESIGN:Analysis of preoperative, 8-week, 1-year, and 2-year data from patients with right thoracic adolescent idiopathic scoliosis treated by posterior Universal Spine System (Stratec Medical, Oberdorf, Switzerland). OBJECTIVE:Report 2-year results and the association between back surface and radiographic assess...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200108150-00009

    authors: Pratt RK,Webb JK,Burwell RG,Cole AA

    更新日期:2001-08-15 00:00:00

  • Pain and psychologic symptoms of Australian patients with whiplash.

    abstract:STUDY DESIGN:A survey of pain intensity and psychological symptoms in patients with chronic neck pain after whiplash injury. OBJECTIVES:To describe the pain and psychological profiles of patients with chronic whiplash. SUMMARY OF BACKGROUND DATA:Reports in the literature mention a constellation of symptoms associated...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199604010-00006

    authors: Wallis BJ,Lord SM,Barnsley L,Bogduk N

    更新日期:1996-04-01 00:00:00

  • The effect on the lumbosacral spine of long spinal fusion for idiopathic scoliosis. A minimum 10-year follow-up.

    abstract::The effect on the lumbosacral spine of long spinal fusion in adolescent idiopathic scoliosis was studied in 22 patients. The average duration of follow-up was 12.8 years. Corrections of the coronal curves through instrumentation were satisfactory. However, a kyphosis was produced at the fused segment of the lumbar spi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198712000-00010

    authors: Luk KD,Lee FB,Leong JC,Hsu LC

    更新日期:1987-12-01 00:00:00

  • Growth in girls with adolescent idiopathic scoliosis.

    abstract::The height development during childhood and puberty was analyzed in 54 girls with adolescent idiopathic scoliosis by the use of the Infancy Childhood Puberty growth model, which is based on healthy Swedish children. This model adjusts adolescent reference values for height for individual age at pubertal maturation. Th...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199201000-00016

    authors: Hägglund G,Karlberg J,Willner S

    更新日期:1992-01-01 00:00:00

  • Prevertebral vascular and esophageal consideration during percutaneous cervical disc procedures.

    abstract:STUDY DESIGN:A retrospective review series. OBJECTIVE:To identify vascular anatomy and esophageal deviations that may interfere with a percutaneous anterior approach in cervical spine surgery. SUMMARY OF BACKGROUND DATA:The percutaneous anterior approach has been used for minimally invasive interventions of cervical ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000140

    authors: Jeon JK,Oh CH,Chung D,Lee J,Choi SH,Choi E,Ji GY

    更新日期:2014-02-15 00:00:00

  • Aseptic loosening of pedicle screw as a result of metal wear debris in a pediatric patient.

    abstract:STUDY DESIGN:This is a case report. OBJECTIVE:To report a case of soft-tissue reaction to wear debris and osteolysis around a pedicle screw after posterior spine fusion in a pediatric patient. SUMMARY OF BACKGROUND DATA:Posterior spine fusion with instrumentation is a standard procedure for stabilization and curve co...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182793e51

    authors: Botolin S,Merritt C,Erickson M

    更新日期:2013-01-01 00:00:00

  • Risk factors and precipitating neck movements causing vertebrobasilar artery dissection after cervical trauma and spinal manipulation.

    abstract:STUDY DESIGN:Potential precipitating events and risk factors for vertebrobasilar artery dissection were reviewed in an analysis of the English language literature published before 1993. OBJECTIVES:To assess the literature pertaining to precipitating neck movements and risk factors for vertebrobasilar artery dissection...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-199904150-00010

    authors: Haldeman S,Kohlbeck FJ,McGregor M

    更新日期:1999-04-15 00:00:00

  • Measurement of lumbar lordosis. Evaluation of intraobserver, interobserver, and technique variability.

    abstract:STUDY DESIGN:Sixty radiographs were measured on two separate occasions by three physicians using four different techniques to evaluate the reliability and reproducibility of the measurement of lumbar lordosis. OBJECTIVE:To evaluate clinical methods of measuring lumbar lordosis, determining intraobserver and interobser...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199607010-00008

    authors: Polly DW Jr,Kilkelly FX,McHale KA,Asplund LM,Mulligan M,Chang AS

    更新日期:1996-07-01 00:00:00

  • Adverse Events Related to Transcranial Electric Stimulation for Motor-evoked Potential Monitoring in High-risk Spinal Surgery.

    abstract:STUDY DESIGN:Prospective multicenter study. OBJECTIVE:The aim of this study was to study the incidence of nonneurologic adverse events related to transcranial electric stimulation (TES) for intraoperative spinal cord monitoring (IOM) with motor-evoked potentials (MEPs) (Tc(E)- MEPs) and determine the need for safety p...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000003115

    authors: Yoshida G,Imagama S,Kawabata S,Yamada K,Kanchiku T,Fujiwara Y,Tadokoro N,Takahashi M,Wada K,Yamamoto N,Ushirozako H,Kobayashi K,Yasuda A,Ando M,Tani T,Matsuyama Y

    更新日期:2019-10-15 00:00:00

  • Role of sodium in the pathophysiology of secondary spinal cord injury.

    abstract:STUDY DESIGN:Experimental study using an in vitro model of compressive injury to isolated adult rat dorsal column axons. OBJECTIVES:To examine the role of extracellular Na+ (Na+e) in mediating secondary injury to spinal cord axons after compressive trauma. The mechanisms of intracellular sodium entry were examined usi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199510001-00002

    authors: Fehlings MG,Agrawal S

    更新日期:1995-10-15 00:00:00

  • Cortical evoked potential monitoring. A system for intraoperative monitoring of spinal cord function.

    abstract::This report describes the intraoperative use of a somatosensory cortical evoked potential system to monitor spinal cord function during 300 orthopedic surgical procedures. This system requires sophisticated equipment and the establishment of normative data but has performed well with no false negatives noted. The most...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Brown RH,Nash CL Jr,Berilla JA,Amaddio MD

    更新日期:1984-04-01 00:00:00

  • The role of anterior spinal instrumentation and allograft fibula for the treatment of pott disease.

    abstract:STUDY DESIGN:The authors retrospectively reviewed 28 patients with multilevel Pott disease who underwent anterior radical débridement, decompression, and fusion with anterior spinal instrumentation and fibular allograft replacement. OBJECTIVES:To assess the efficacy of allograft fibular fusion and anterior spinal stab...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000048666.17934.17

    authors: Ozdemir HM,Us AK,Oğün T

    更新日期:2003-03-01 00:00:00

  • Disc inflammation potentially promotes axonal regeneration of dorsal root ganglion neurons innervating lumbar intervertebral disc in rats.

    abstract:STUDY DESIGN:The expression of growth-associated protein 43 (GAP-43), a marker of axonal growth, in the dorsal root ganglion (DRG) neurons innervating the lumbar intervertebral disc was assessed using the retrograde tracing method and immunohistochemistry. OBJECTIVES:To study whether disc inflammation affects GAP-43 e...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000146051.11574.b4

    authors: Aoki Y,Ohtori S,Ino H,Douya H,Ozawa T,Saito T,Moriya H,Takahashi K

    更新日期:2004-12-01 00:00:00

  • Facet asymmetry in normal vertebral growth: characterization and etiologic theory of scoliosis.

    abstract:STUDY DESIGN:The shape and orientation of the thoracic and lumbar zygapophyseal facets at the T1-L5 level in children were measured and analyzed. OBJECTIVE:To detect the pattern of zygapophyseal facet asymmetry in the thoracic and lumbar spines in children. SUMMARY OF BACKGROUND DATA:Whereas many studies have defined...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31816b1f83

    authors: Masharawi YM,Peleg S,Albert HB,Dar G,Steingberg N,Medlej B,Abbas J,Salame K,Mirovski Y,Peled N,Hershkovitz I

    更新日期:2008-04-15 00:00:00

  • Is the Readability of Spine-Related Patient Education Material Improving?: An Assessment of Subspecialty Websites.

    abstract:STUDY DESIGN:Analysis of spine-related patient education materials (PEMs) from subspecialty websites. OBJECTIVE:The aim of this study was to assess the readability of spine-related PEMs and compare to readability data from 2008. SUMMARY OF BACKGROUND DATA:Many spine patients use the Internet for health information. S...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001446

    authors: Eltorai AEM,Cheatham M,Naqvi SS,Marthi S,Dang V,Palumbo MA,Daniels AH

    更新日期:2016-06-01 00:00:00

  • Platelet-rich plasma (PRP) stimulates the extracellular matrix metabolism of porcine nucleus pulposus and anulus fibrosus cells cultured in alginate beads.

    abstract:STUDY DESIGN:In vitro assessment of the effects of platelet-rich plasma on the extracellular matrix metabolism of porcine intervertebral disc cells. OBJECTIVES:To determine whether platelet-rich plasma is effective in stimulating cell proliferation and extracellular matrix metabolism by porcine disc cells cultured in ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000214942.78119.24

    authors: Akeda K,An HS,Pichika R,Attawia M,Thonar EJ,Lenz ME,Uchida A,Masuda K

    更新日期:2006-04-20 00:00:00

  • Biomechanics of cervical spine facetectomy and fixation techniques.

    abstract::Facetectomy, either unilateral or bilateral, significantly altered the capacity of cervical spine functional units to withstand increasing compression-flexion loads applied in a constant mode to different specimen configurations. Unilateral facetectomy resulted in an average 31.6 +/- 9.7 percent decrease in strength w...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198807000-00017

    authors: Cusick JF,Yoganandan N,Pintar F,Myklebust J,Hussain H

    更新日期:1988-07-01 00:00:00

  • Collagen crosslinks in human lumbar intervertebral disc aging.

    abstract:STUDY DESIGN:Human lumbar intervertebral discs from individuals of varying ages were obtained at autopsy and analyzed for collagen crosslinks. OBJECTIVES:To analyze alterations in collagen crosslinks in human lumbar intervertebral discs with aging and disc degeneration. Crosslinks studied were pyridinoline, which is a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199808010-00005

    authors: Pokharna HK,Phillips FM

    更新日期:1998-08-01 00:00:00

  • Functional importance of degenerative spondylolisthesis in cervical spondylotic myelopathy in the elderly.

    abstract:STUDY DESIGN:A correlation was studied between degenerative spondylolisthesis (DSL) of the cervical spine and spinal-evoked potentials intraoperatively recorded in elderly patients who had surgical treatment for cervical spondylotic myelopathy. OBJECTIVE:To investigate the functional importance of cervical DSL in elde...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:10.1097/01.BRS.0000067263.73474.97

    authors: Tani T,Kawasaki M,Taniguchi S,Ushida T

    更新日期:2003-06-01 00:00:00

  • Early detection of progression in adolescent idiopathic scoliosis by measurement of changes in back shape with the Integrated Shape Imaging System scanner.

    abstract:STUDY DESIGN:A retrospective study of 78 patients with right thoracic idiopathic scoliosis was done. OBJECTIVES:To evaluate the reliability of the integrated Shape Imaging System scan (Oxford Metrics Ltd, Oxford, UK) in detecting progression of scoliosis and the use of back shape data in predicting scoliosis progressi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199706010-00010

    authors: Theologis TN,Fairbank JC,Turner-Smith AR,Pantazopoulos T

    更新日期:1997-06-01 00:00:00

  • Vertebral 'corner' defect associated with lumbar disk herniation shown by magnetic resonance imaging.

    abstract::Two examples of a marked defect of the corner of the vertebral body adjacent to an intervertebral disk herniation are presented. The prevalence of this finding was assessed in 43 randomly selected patients with disk herniation (at 46 levels). None of these patients had such marked vertebral defects (moderate changes a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199301000-00016

    authors: Vincent JM,Baldwin JE,Sims C,Dixon AK

    更新日期:1993-01-01 00:00:00

  • An acute cervical epidural hematoma as a complication of dry needling.

    abstract:STUDY DESIGN:A retrospective case report. OBJECTIVE:The objective of this article is to report an unusual complication of dry needling. SUMMARY OF BACKGROUND DATA:Epidural hematomas after dry needling are quite unusual and only a few cases of epidural hematoma after acupuncture have been reported in the literature. W...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181fc1e38

    authors: Lee JH,Lee H,Jo DJ

    更新日期:2011-06-01 00:00:00