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Adjuvant oral razoxane (ICRF-159) in resectable colorectal cancer.

Abstract：

:One hundred and seventy six patients (81 controls, 95 receiving treatment) have entered a prospective randomized trial of long-term oral adjuvant razoxane (ICRF-159) following removal of a colorectal cancer. The median follow-up is 34 months. The treated patients in Dukes' groups B and C have a significantly longer disease-free interval than the control patients (P = 0.01 'as randomized' and P = 0.004 'as treated'). The differences in survival for Dukes' groups B and C are not significant, although follow-up is short. In Dukes' groups B and C, however, 24 of 56 of the patients in the control group have died (43%), as against only 17 of 64 in the treatment group (27%). The treatment produces very few side-effects, is well tolerated by patients, and is taken orally.

journal_name

Cancer Chemother Pharmacol

journal_title

Cancer chemotherapy and pharmacology

authors

Gilbert JM,Hellmann K,Evans M,Cassell PG,Stoodley B,Ellis H,Wastell C

doi

10.1007/BF00254053

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

293-9

issue

3

eissn

0344-5704

issn

1432-0843

journal_volume

8

pub_type

临床试验,杂志文章,随机对照试验

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