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Induction of hepatic microsomal enzymes by diuron, phenobenzuron, and metabolites in rats.

Abstract：

:Microsomal liver enzymes are induced in rats which are fed a diet containing 1000 ppm of phenobenzuron, a phenylurea herbicide, for 7 days: All parameters measured are about 50% higher than control values. This increase is lower after 14 feeding days. Diuron and 3,4-dichloroaniline have a similar, although lower, effect than phenobenzuron. Two other metabolites have no action on microsomal enzymes. The transitory and weak inducing effect of these phenylureas is interesting when compared to other organochlorine pesticides.

journal_name

Ecotoxicol Environ Saf

journal_title

Ecotoxicology and environmental safety

authors

Corthay J,Medilanski P,Benakis A

doi

10.1016/0147-6513(77)90035-5

subject

Has Abstract

pub_date

1977-09-01 00:00:00

pages

197-202

issue

2

eissn

0147-6513

issn

1090-2414

pii

0147-6513(77)90035-5

journal_volume

1

pub_type

杂志文章

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