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Quinazolines and 1,4-benzodiazepines. 90. Structure-activity relationship between substituted 2-amino-N-(2-benzoyl-4-chlorophenyl)acetamides and 1,4-benzodiazepinones.

Abstract：

:The syntheses of 2-amino-N-(2-benzoyl)-4-chlorophenyl)acetamides are reported. The pharmacological properties of these compounds were compared with data obtained from the corresponding cyclized products [5-(2,6-dichlorophenyl)-1,4-benzodiazepin-2-ones]. Evidence is presented which suggests that the central nervous system activity observed for 1,4-benzodiazepines is inherent only in the closed seven-membered ring and is not due to the ring-opened form.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Fryer RI,Leimgruber W,Trybulski EJ

doi

10.1021/jm00351a009

subject

Has Abstract

pub_date

1982-09-01 00:00:00

pages

1050-5

issue

9

eissn

0022-2623

issn

1520-4804

journal_volume

25

pub_type

杂志文章

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