Double-blind evaluation of collagenase injections for herniated lumbar discs.

Abstract:

:A randomized clinical trial of 30 patients with refractory lumbar disc disease with evidence of a herniation at a single intervertebral space on the myelogram is presented. Collagenase or a saline placebo was injected into the affected disc. Lack of pain reduction or lack of functional improvement was considered a therapeutic failure. Patients who failed to respond to the placebo could subsequently receive a collagenase injection. Thirty-three percent (33%) of the 15 patients who received a placebo and 80% of the 15 patients who received collagenase were rated successful 8 weeks after injection. The study demonstrates a statistically significant effectiveness of collagenase in the treatment of herniated lumbar disc disease.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Bromley JW,Varma AO,Santoro AJ,Cohen P,Jacobs R,Berger L

doi

10.1097/00007632-198407000-00012

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

486-8

issue

5

eissn

0362-2436

issn

1528-1159

journal_volume

9

pub_type

临床试验,杂志文章,随机对照试验

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