Abstract:
:A randomized clinical trial of 30 patients with refractory lumbar disc disease with evidence of a herniation at a single intervertebral space on the myelogram is presented. Collagenase or a saline placebo was injected into the affected disc. Lack of pain reduction or lack of functional improvement was considered a therapeutic failure. Patients who failed to respond to the placebo could subsequently receive a collagenase injection. Thirty-three percent (33%) of the 15 patients who received a placebo and 80% of the 15 patients who received collagenase were rated successful 8 weeks after injection. The study demonstrates a statistically significant effectiveness of collagenase in the treatment of herniated lumbar disc disease.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Bromley JW,Varma AO,Santoro AJ,Cohen P,Jacobs R,Berger Ldoi
10.1097/00007632-198407000-00012subject
Has Abstractpub_date
1984-07-01 00:00:00pages
486-8issue
5eissn
0362-2436issn
1528-1159journal_volume
9pub_type
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