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One-electron redox reactions of pyrazolin-5-ones. A pulse radiolysis study of antipyrine and analogues.

Abstract：

:One-electron oxidation of several derivatives of pyrazolin-5-one, including the drug antipyrine, were studied by pulse radiolysis of aqueous solutions. All the compounds were found to be oxidized by Br2 rapidly (k approximately 3 X 10(8)-2 X 10(9) M-1 s-1) but considerably more slowly by weaker oxidants, such as peroxyl radicals. From redox equilibria using p-methoxyphenol and N,N,N',N'-tetramethyl-p-phenylenediamine as reference compounds, the one-electron oxidation potentials of the methyl-substituted 2-pyrazolin-5-ones were found to be in the range of 0.32-0.39 V versus normal hydrogen electrode. The relevance of these findings to the properties of the drug nafazatrom is discussed. Antipyrine was found to have a much higher oxidation potential, estimated as 1.2-1.5 V, which is rationalized on the basis of the phenyl substitution and lack of resonance stabilization of the radical cation.

journal_name

Mol Pharmacol

journal_title

Molecular pharmacology

authors

Jovanovic SV,Neta P,Simic MG

subject

Has Abstract

pub_date

1985-10-01 00:00:00

pages

377-80

issue

4

eissn

0026-895X

issn

1521-0111

journal_volume

28

pub_type

杂志文章

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