In vitro effects of cadmium chloride on preimplantation rat embryos.

Abstract:

:Preimplantation rat embryos (8-cell, morulae, blastocysts) were incubated for 24 hr in vitro in a Brinster medium with or without cadmium chloride (1 microgram/ml). CdCl2 arrested the development of both the 8-cell and morulae into blastocysts. Morphologic observations revealed the 8-cell embryo to have shrunken cells and pyknotic nuclei. Morulae appeared smaller in size with fewer cells than comparable controls. CdCl2 was clearly cytotoxic to the early blastocysts, inner mass cells were most damaged with cell death, pyknosis, and accumulation of debris.

journal_name

Ecotoxicol Environ Saf

authors

Abraham R,Charles AK,Mankes R,LeFevre R,Renak V,Ashok L

doi

10.1016/0147-6513(86)90013-8

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

213-9

issue

3

eissn

0147-6513

issn

1090-2414

pii

0147-6513(86)90013-8

journal_volume

12

pub_type

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