Translational Highlights in Breast and Ovarian Cancer 2019 - Immunotherapy, DNA Repair, PI3K Inhibition and CDK4/6 Therapy.

Abstract:

:In the near future, important translational questions of clinical relevance will be adressed by studies currently in progress. On the one hand, the role of PD-L1 expression must be further understood, after it was found to be relevant in the use of atezolizumab in first-line therapy of patients with metastatic triple-negative breast cancer (TNBC). No association between efficacy and PD-L1 expression was found in a neoadjuvant study that included pembrolizumab in TNBC. The pathological complete response rate (pCR) was higher in both patient groups with and without PD-L1 expression when pembrolizumab was added to chemotherapy. Another future question is the identification of further patient groups in which efficacy of PARP inhibitors is seen, which are licensed for the pBRCA1/2 germline mutation. These include, for example, patients with mutations in other genes, which are involved in homologous recombination, or patients with tumours that show an abnormality in global tests of homologous recombination deficiencies (HRD tests). The question of whether a PARP inhibitor can be given and with which chemotherapy combination partners is currently being investigated in both breast and ovarian cancer. While the data on improved overall survival are being consolidated for the CDK4/6 inhibitors, knowledge of molecular changes during the therapy and during progression on the therapy is growing. Both the accumulation of PI3K mutations and also PTEN changes might play a part in planning subsequent therapies. This review article summarises these recent developments in breast cancer and in part also in ovarian cancer.

authors

Hartkopf AD,Müller V,Wöckel A,Lux MP,Janni W,Ettl J,Belleville E,Schütz F,Fasching PA,Kolberg HC,Welslau M,Overkamp F,Taran FA,Brucker SY,Wallwiener M,Tesch H,Fehm TN,Schneeweiss A,Lüftner D

doi

10.1055/a-1039-4458

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1309-1319

issue

12

eissn

0016-5751

issn

1438-8804

pii

10394458

journal_volume

79

pub_type

杂志文章
  • [Operative correction of a urogenital malformation with persistent cloaca].

    abstract::A case of malformation of the urogenital system with a persistent urogenital sinus and a cloaca is reported. There was unilateral agenesis of the kidney, megaureter and a double ureter with an ureteral orifice into the vagina and the clitoris. There was a double uterus and vagina with an orifice into the terminal gut....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036928

    authors: Künzig HJ,Engelking R,Gharib M

    更新日期:1982-08-01 00:00:00

  • [Interchange of babies in Portugal by exclusions in the ADA, GPT, ESD and HLA systems (author's transl)].

    abstract::The suspicion of an interchange of babies in two Portuguese families could not be dissipated in the first course of testing the following systems being considered: AB0, MNSs, Rhesus, Kell, Cellano, Duffy. Including further markers in an additional opinion, multiple father- and mother-exclusions could be made in the sy...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037185

    authors: Weissmann J,Cancella d'Abreu AF,Pribilla O

    更新日期:1981-06-01 00:00:00

  • [Preoperative reduction of uterine leiomyoma by the GnRH-analog goserelin (zoladex)].

    abstract::The administration of GnRH analogues is expected to improve treatment by avoiding hysterectomy, since problems connected with the surgical removal of leiomyomata are correlated with their size. In this study the GnRH analogue goserelin in its depot formulation (Zoladex, ICI, Plankstadt) was used for treating isolated ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026451

    authors: Hackenberg R,Gesenhues T,Deichert U,Duda V,Sturm G,Schulz KD

    更新日期:1990-02-01 00:00:00

  • [Comparison of different methods for estimating fetal weight by cephalo- and abdominometry (author's transl)].

    abstract::To check the accuracy of different published methods of fetal weight estimation based on head and abdominal parameters, all methods were used in every individual case in 123 pregnancies. It became apparent that the single methods gave the best results in different indications. As far as normal fetal development at ter...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036975

    authors: Bernaschek G,Kratochwil A

    更新日期:1981-02-01 00:00:00

  • [Possibilities of therapy by ear acupuncture in female sterility].

    abstract::Following differentiated endocrinologic-gynecologic diagnosis auricular acupuncture was used in 15 women with oligoamenorrhea and 12 women with luteal body insufficiency who had come for hormone consultation because of sterility. In both groups the subsequent incidence of pregnancy was comparable to that achieved by d...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035717

    authors: Gerhard I,Postneek F

    更新日期:1988-03-01 00:00:00

  • [Does lung maturation therapy with 16-methylene-prednisolone modify maternal infection parameters in threatened premature labor?].

    abstract:UNLABELLED:Silent intrauterine infection is a frequent cause of preterm labour. Maternal C-reactive protein (CRP) and leukocyte count are important predictors of such infections. Treatment with corticosteroids is known to elevate leukocyte count and in this manner can possibly interfere with its accuracy as a predictor...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1023237

    authors: Winkler M,Heyl W,Reister F,Rath W

    更新日期:1996-06-01 00:00:00

  • [Incidence of hyperandrogenemia].

    abstract::Within two years 341 amenorrheic patients treated in our endocrinological outpatient department were listed up retrospectively in WHO-classification groups. In 30 patients a primary amenorrhea and in 311 patients a secondary amenorrhea could be registered. In 28.3% a hypothalamic pituitary disorder must be diagnosed, ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036049

    authors: Gitsch E,Vytiska-Binstorfer E,Huber JC

    更新日期:1987-11-01 00:00:00

  • The Patients' View On Accredited Breast Cancer Centers: Strengths and Potential for Improvement.

    abstract::Breast Care Centers that were accredited according to the German Cancer Society criteria were offered to participate in a standardized patient survey in 2010, which was conducted by the Institute for Medical Sociology, Health Services Research and Rehabilitation Science, Faculty of Human Science and Faculty of Medicin...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280475

    authors: Kowalski C,Wesselmann S,Kreienberg R,Schulte H,Pfaff H

    更新日期:2012-02-01 00:00:00

  • [Cardiotocography with or without fetal blood analysis].

    abstract::It is the aim of obstetric medicine to achieve optimum safety for both mother and child with a minimum of surgery. In normal clinical routine, this demand cannot be fully met by the sole use of cardiotocography for monitoring the foetus sub partu. Obviously the weak point of cardiotocographical diagnosis is that often...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036232

    authors: Saling E

    更新日期:1985-03-01 00:00:00

  • [Hermann Johannes Pfannenstiel (1862-1090). On the 80th anniversary of his death. A biography of a famous German gynecologist].

    abstract::The gynaecologist Hermann Johannes Pfannenstiel died 80 years ago, on July 3, 1909, from the sequelae of an occupational accident. His death marked the unexpected end of a splendid career as a physician, whose heritage in terms of humanity and scientific achievements is most impressive, even today. Pfannenstiel was bo...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 传,历史文章,杂志文章

    doi:10.1055/s-2007-1026488

    authors: Jensen A

    更新日期:1990-04-01 00:00:00

  • [Breech presentation of the second twin. Effect on early morbidity and perinatal mortality].

    abstract::Twin delivery is often complicated by breech presentation of the second twin. To investigate the influence of breech presentation of the second twin, we reviewed all 259 twin deliveries from the 18,404 deliveries at our institution over 11 years between 1978 to 1989. The neonatal morbidity of the second twin in breech...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026381

    authors: Queck M,Hitschold T,Berle P

    更新日期:1990-11-01 00:00:00

  • Hormone Therapy and its Effect on the Prognosis in Breast Cancer Patients.

    abstract::Introduction: Use of hormone therapy (HT) has declined dramatically in recent years. Some studies have reported that HT use before a diagnosis of breast cancer (BC) may be a prognostic factor in postmenopausal patients. This study aimed to examine the prognostic relevance of HT use before BC diagnosis. Methods: Four B...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0035-1546149

    authors: Rauh C,Schuetz F,Rack B,Stickeler E,Klar M,Orlowska-Volk M,Windfuhr-Blum M,Heil J,Rom J,Sohn C,Andergassen U,Jueckstock J,Fehm T,Loehberg CR,Hein A,Schulz-Wendtland R,Hartmann A,Beckmann MW,Janni W,Fasching PA,Häb

    更新日期:2015-06-01 00:00:00

  • Criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for the Classification of Germline Sequence Variants in Risk Genes for Hereditary Breast and Ovarian Cancer.

    abstract::More than ten years ago, the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) set up a panel of experts (VUS Task Force) which was tasked with reviewing the classifications of genetic variants reported by individual centres of the GC-HBOC to the central database in Leipzig and reclassifying them, w...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-1110-0909

    authors: Wappenschmidt B,Hauke J,Faust U,Niederacher D,Wiesmüller L,Schmidt G,Groß E,Gehrig A,Sutter C,Ramser J,Rump A,Arnold N,Meindl A

    更新日期:2020-04-01 00:00:00

  • [Rectoanal rest and stress pressure profile of the female for detecting fecal incontinence].

    abstract::In this article, the method used to record rectoanal rest and stress patterns is described. With reference to sample graphs and tabulated results, normal values in continent women are demonstrated. Results are discussed together with references in the literature. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036158

    authors: Voigt R,Illessy G

    更新日期:1986-01-01 00:00:00

  • [Cervix cytology and primary malignancies of the gastrointestinal tract].

    abstract::During the cancer check-up of a 46-year-old woman a PAP V was diagnosed in the cervical scrapings. The atypical cells of the abrasion specimens from the corpus uteri arouse strong suspicion of malignancy. Connected with the clinical data, this finding primarily indicated a metastatic involvement of the inner genitals....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036064

    authors: Jaluvka V,Engelhardt W

    更新日期:1987-12-01 00:00:00

  • [The value of etoposide (VP-16) in the therapy of refractory ovarian cancer].

    abstract::In analogy to Kühnle et al. (1984) the role of etoposide in patients with cisplatin-refractory ovarian cancer was evaluated. 45 patients were treated with 150-200 mg of etoposide per sa. m. on days 1-3. Acute toxicity was tolerable except alopecia grade III. Remarkable, however, was the induction of two fatal cases of...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022887

    authors: Marth C,Pointner E,Zeimet AG,Abfalter E,Koza A,Windbichler G,Hetzel H,Dapunt O

    更新日期:1993-05-01 00:00:00

  • [Treatment of tubal pregnancy by pelviscopy--complications, pregnancy and recurrence rates].

    abstract::From 1977-1989, 298 ectopic pregnancies were treated pelviscopically at the Dept. of Gynaecology Hospital of the University of Kiel. 26 tubes were already ruptured. In 251 patients (84%), organ preserving treatment was possible, 205 treatment by longitudinal salpingotomy. 46 tubal abortions were extracted. In 47 patie...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026197

    authors: Mecke H,Argiriou C Semm K

    更新日期:1991-07-01 00:00:00

  • [Descriptive epidemiology and prognosis of malignant gynecologic tumors].

    abstract::Based on data from the Saarland (W. Germany) Cancer Registry, epidemiology and prognosis of gynaecological malignancies is presented for the period 1971-1985. Breast cancer is the most frequent gynaecological tumour followed by tumours of the uterus (cervix + corpus). This is in accordance with worldwide observations....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035842

    authors: Kolles H,Stegmaier C,von Seebach HB,Ziegler H

    更新日期:1989-06-01 00:00:00

  • Pregnancies in Women Aged 45 Years and Older - a 10-Year Retrospective Analysis in Berlin.

    abstract::Introduction Improved fertility treatment options and a change in the socio-cultural concept of family planning, especially in industrialized regions, has led to an increasing number of births by women of advanced maternal age, which is associated with a higher rate of complications. The aim of this study was to analy...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0043-100105

    authors: Rendtorff R,Hinkson L,Kiver V,Dröge LA,Henrich W

    更新日期:2017-03-01 00:00:00

  • [The prognostic value of lymphangiosis carcinomatosa and malignancy grading in T1/T2-N0 cancers of the breast using 10 or fewer examined axillary lymph nodes].

    abstract::In 270 cases of T1 and T2 carcinomas of the breast with ten or less axillary lymph nodes having been examined, the prognostic relevance of the histopathological statement of nodal negativity was assessed in a retrospective study. In this collective study, the mean number of lymph nodes examined was 4.1 +/- 1.9 for the...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035755

    authors: Stauch G,Szulfer CC,Hilfrich J,Georgii A

    更新日期:1989-03-01 00:00:00

  • [Eye diseases and control of labor. Studies of changes in the eye in labor exemplified by subconjunctival hemorrhage (hyposphagmas)].

    abstract::The possible significance of subconjunctival bleedings (hyposphagmas) as a symptom for other pathological changes of the eye was studied in a group of 354 postpartum patients. They were found in 10.5% of the cases. A relatively higher frequency occurred in primiparas. No other maternal factors than parity were detecte...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026600

    authors: Stolp W,Kamin W,Liedtke M,Borgmann H

    更新日期:1989-04-01 00:00:00

  • [Malaria relapse in the puerperium].

    abstract::During the last six years we observed four malaria relapses shortly after delivery. In three cases the relapse occurred subsequent to Caesarean section, and in one case shortly after normal uncomplicated delivery. Case histories revealed that these women had previously stayed in the tropical or subtropical zones. The ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036513

    authors: Harms E,Degner-Harms I,Klöck FK

    更新日期:1984-11-01 00:00:00

  • [The operated adenocarcinoma of the cervix uteri (author's transl)].

    abstract::Out of a total of 1092 women operated because of cervical carcinoma, 4.8% had an adenocarcinoma of the cervix. Compared with patients with squamous cell carcinoma, there was no difference in signs and clinical pattern with those patients who had adenocarcinoma of the cervix. Treatment results, too, corresponded with t...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Baltzer J,Köpcke W,Zander J

    更新日期:1979-12-01 00:00:00

  • [The older primipara: labor induction and rigidity of the soft tissues].

    abstract::Textbooks and literature reports frequently view the primipara of advanced age as a group being at increased risk of prolonged labor, dystocia, injuries to the birth canal and fetal distress. Particularly, a rigid cervix and reduced elasticity of the soft tissues of the birth canal are claimed responsible for these ri...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026496

    authors: Radivojevic K,Rudelstorfer R

    更新日期:1988-04-01 00:00:00

  • [Investigations into the hormonal regulation of the corpus luteum function in the human (author's transl)].

    abstract::In estradiol micro-crystalline suspension was injected into the ovary containing the corpus luteum in women who underwent hysterectomy. The same complete luteaolysis is in women who did not have hysterectomies was obtained. The conclusion is drawn that the prostaglandins which are formed in the uterus have no influenc...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Kayser W,Hoffmann F

    更新日期:1979-11-01 00:00:00

  • [Postoperative pain in patients after conventional abdominal and endoscopic surgery hysterectomy--a comparative study].

    abstract::The purpose of the present study is to determine differences in the postoperative character of pain between two study groups undergoing different techniques of hysterectomy. Therefore we examined 42 women. 21 women underwent combined laparoscopic and vaginal hysterectomy and 21 abdominal hysterectomies have been perfo...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022348

    authors: Malik E,Scheidel P

    更新日期:1994-11-01 00:00:00

  • [Ranking of hysterosalpingography (HSG) in the physician's consultation-room practice concerning sterility problems (author's transl)].

    abstract::In the following up of the diagnosis of the female sterility we practised 123 hysterosalpingographies (HSG) from 1972--1978. Presupposition was the proof of the ovulation by base temperature. The HSG is the beginning of the diagnosis to recognize the intracanalicular changes of the uterus and to avoid senseless treatm...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037290

    authors: Fettig O,Heilmann R

    更新日期:1981-07-01 00:00:00

  • [Seasonal fluctuations in the sex ratio of new borns and the influence of the declining birth rate on the sex ratio (author's transl)].

    abstract::Seasonal fluctuations in the sex ratio of new borns are investigated. The largest predominance of male deliveries over female deliveries was found to be during the conception months May-June with an almost constant number of deliveries. The highest value was in June. Seasonal maximum of the male to female sex ratio is...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Hoffmann F

    更新日期:1979-03-01 00:00:00

  • [Studies on the birth-weight and the size of the new-born child with reference to the parity of the mother (author's transl)].

    abstract::The relation between the parity of the mother and the birth-weight as well as the size of the new-born child, taking into account the sex, were examined as follows: From the patients needing obstretical care during the period of 1966 to 1971 those 3441 women were chosen who had born twice or more times during this tim...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Trotnow S,Bregulla K,Flügel K

    更新日期:1976-09-01 00:00:00

  • [Results of transabdominal placental biopsy in the 2nd and 3d trimester].

    abstract::From August 1988 to October 1990, 115 transabdominal placental biopsies were performed in the second (68%) and third trimenon (32%). The main indication (80%) was the detection of pathological ultrasonographic findings (foetal malformation, growth retardation, oligohydramnios and polyhydramnios). The success rate of c...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1023686

    authors: Crombach G,Schütz S,Schlensker KH

    更新日期:1991-02-01 00:00:00