Abstract:
STUDY DESIGN:Prospective cohort study. OBJECTIVE:To analyze the serum and drain concentrations of antibiotics administered by two different routes and compare the results. SUMMARY OF BACKGROUND DATA:Systemic antibiotics are expected to reach the surgical site and maintain adequate concentrations of the drug to prevent infection. However, it is unknown whether systemically administered antibiotics reach and maintain such adequate concentrations at the surgical wound or not. METHODS:Forty patients undergoing elective spine surgery received intra-wound Vancomycin (1 GM) before the wound closure and single dose of intravenous Gentamycin (80MG) immediately after surgery. Blood and drain samples were collected postoperatively to estimate serum and drain concentrations of Gentamycin and Vancomycin. Drug Estimation Protocol: Drug concentrations were estimated by ADVIA Centaur CP immunoassay (direct chemiluminescence). Gentamycin and vancomycin in the test samples competes with their respective acridinium ester-labeled gentamicin and vancomycin derivatives for monoclonal mouse anti-gentamycin and anti-vancomycin antibodies which are covalently coupled to paramagnetic particles in the solid phase. RESULTS:Gentamycin attained peak serum levels at 6 hours following administration with an average value of 9.90 ± 3.1 μg/mL which was decreased to 6.76 ± 2.6 μg/mL at 12 hours and steadily declining thereafter. Even though, the drug concentrations in the drain collection from the wound also attained peak levels at 6 hours, the drug concentrations were lower (3.75 ± 1.4 μg/mL) than that of serum concentrations and inadequately attained the recommended target peak of Gentamycin (4-12 μg/mL).Wound levels of local vancomycin were significantly higher at 6 hours (413.4 ± 217.3 μg/mL) and well maintained even at 72 hours. Serum vancomycin levels were observed to be highest at 6 hours in negligible concentrations of 6.06 ± 2.2 μg/mL. CONCLUSION:After prophylactic systemic administration of the antibiotics, the antibiotic drug concentrations in the wound are much lower than the serum concentrations at any given time. After local intra-wound application of antibiotics, the drug concentrations in the wound are well maintained even after 72 hours. LEVEL OF EVIDENCE:3.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Naresh-Babu J,Arun-Kumar Vdoi
10.1097/BRS.0000000000003238subject
Has Abstractpub_date
2020-02-15 00:00:00pages
E196-E202issue
4eissn
0362-2436issn
1528-1159pii
00007632-202002150-00008journal_volume
45pub_type
杂志文章相关文献
SPINE文献大全abstract:STUDY DESIGN:A retrospective single-center study. OBJECTIVE:This study sought to clarify the risk factors and to evaluate the surgical outcome in patients with rapidly progressive cervical spondylotic myelopathy (rp-CSM). SUMMARY OF BACKGROUND DATA:CSM is a degenerative spine disease presenting a slow development of ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002969
更新日期:2019-06-15 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:To describe a sudden spinal cord injury in a girl with Prader-Willi syndrome (PWS) 1 week after posterior T2-L3 fusion. SUMMARY OF BACKGROUND DATA:PWS is a genetic disorder characterized by several features including growth deficiency, hypotonia, obesity, and spinal deformities. In...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318216d357
更新日期:2011-12-15 00:00:00
abstract:STUDY DESIGN:A case of intradural venous varix producing a mass-like lesion in the lumbar spine is reported. OBJECTIVE:To present a rare cause of an intradural mass lesion along the cauda equina. To present radiologic findings of this entity and to offer a hypothesis for its formation. SUMMARY OF BACKGROUND DATA:Epid...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000085359.59829.44
更新日期:2003-10-15 00:00:00
abstract:STUDY DESIGN:Fifty-one consecutive patients who underwent extradural sensory rhizotomy for chronic radiculopathy after lumbar surgery were reviewed retrospectively. OBJECTIVES:To determine the effectiveness of sensory rhizotomy in the management of chronic radiculopathy in patients selected by extensive imaging techni...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199710010-00018
更新日期:1997-10-01 00:00:00
abstract::Idiopathic juvenile osteoporosis is an unusual condition appearing in the prepubertal child who is otherwise normal. Characteristically, the condition is of variable severity and of limited duration and always affect the spine. One of the major complications of idiopathic juvenile osteoporosis has been residual kyphos...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198101000-00001
更新日期:1981-01-01 00:00:00
abstract:STUDY DESIGN:Prospective observational study. OBJECTIVE:This study aims to quantify the incidence of intraoperative waste in spine surgery and to examine the efficacy of an educational program directed at surgeons to induce a reduction in the intraoperative waste. SUMMARY OF BACKGROUND DATA:Spine procedures are assoc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31822a58c1
更新日期:2011-09-01 00:00:00
abstract:STUDY DESIGN:Acute respiratory compromise is occasionally observed in a subgroup of patients with upper spinal injuries involving the C2 vertebrae. A retrospective review was performed to identify fracture types and risk factors for early respiratory deterioration following injury to the upper cervical spine. OBJECTIV...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200102150-00004
更新日期:2001-02-15 00:00:00
abstract:STUDY DESIGN:Case report. OBJECTIVE:To report a case of false-negative intraoperative motor-evoked potentials (MEP) that developed paraplegia after surgery. SUMMARY OF BACKGROUND DATA:Although several false-negative results have been reported with somatosensory-evoked potentials, there is no report noted with MEP. Th...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3181b40d4f
更新日期:2009-11-15 00:00:00
abstract:STUDY DESIGN:Cost-effectiveness analysis. OBJECTIVE:To examine the cost-effectiveness of operative versus non-operative treatment of type-II odontoid fractures in patients older than 64 years old. SUMMARY OF BACKGROUND DATA:Significant controversy exists regarding the optimum treatment of geriatric patients with type...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001275
更新日期:2016-04-01 00:00:00
abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To evaluate the clinical outcomes of 4 different procedures for the treatment of adjacent multisegmental spinal tuberculosis (AMSST) and to investigate the selection strategy of the optimal procedure with respect to focal characteristics. SUMMARY OF BACKGROUND DATA:Because ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000053
更新日期:2014-01-01 00:00:00
abstract:STUDY DESIGN:A prospective radiographic analysis of cervical spondylotic myelopathy (CSM). OBJECTIVE:The aim of this study was to clarify the pathophysiology of CSM, and use the characteristic of global spinal alignment for determining the surgical strategy. SUMMARY OF BACKGROUND DATA:Radiographic evaluation of CSM, ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002253
更新日期:2018-02-01 00:00:00
abstract:STUDY DESIGN:A surgical technique for primary closure of postoperative subfascial infections is described. OBJECTIVES:To describe the methods and indications for the use of the interconnected latissimus dorsi-gluteus maximus flap. SUMMARY OF BACKGROUND DATA:Closure of subfascial postoperative infection can be complic...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199703010-00021
更新日期:1997-03-01 00:00:00
abstract:STUDY DESIGN:A retrospective study. OBJECTIVE To clarify the characteristics of respiratory dysfunction associated with chronic-onset cervical myelopathy. SUMMARY OF BACKGROUND DATA:In acute cervical cord injury, respiratory dysfunction, especially vital capacity (VC), is impaired, which causes respiratory complicatio...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200210150-00010
更新日期:2002-10-15 00:00:00
abstract:STUDY DESIGN:Systematic review. OBJECTIVE:To determine the effects of acupuncture for individuals with neck pain. SUMMARY OF BACKGROUND DATA:Neck pain is one of the 3 most frequently reported complaints of the musculoskeletal system. Treatments for neck pain are varied, as are the perceptions of benefits. METHODS.: W...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000252100.61002.d4
更新日期:2007-01-15 00:00:00
abstract:STUDY DESIGN:Cervical pedicle morphology was investigated using manual and computed tomography measurements. OBJECTIVES:Normal anatomic variations of the cervical pedicles were measured to evaluate their safety as anchors for posterior cervical fixation systems. SUMMARY OF BACKGROUND DATA:There have been no cervical ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199703010-00005
更新日期:1997-03-01 00:00:00
abstract::One of the problems arising from the consideration of safely during manual handling in industry has been, firstly, a definition of those workers at risk and, secondly, a definition of safely. To be able objectively to identify those a risk and quantify the stress to which they are exposed, a more rigorous series of cr...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198101000-00018
更新日期:1981-01-01 00:00:00
abstract:STUDY DESIGN:Case-control study. OBJECTIVE:This study is to replicate the association between the promoter polymorphisms of matrix metalloproteinase (MMP)-3 (-1171 5A/6A rs3025058) and interleukin (IL)-6 genes (-174G/C rs1800795) and adolescent idiopathic scoliosis (AIS) in a Chinese Han population. SUMMARY OF BACKGR...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181c6ba13
更新日期:2010-08-15 00:00:00
abstract:OBJECTIVE:The purpose of this study was to analyze the nature and cause of spinal disabilities among military and civil aircrew in India. SUMMARY OF BACKGROUND DATA:Studies suggest that military aircrew may be more prone than nonaviators to develop spinal disabilities. An in-depth analysis of such disabilities can ena...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817bb9aa
更新日期:2008-12-01 00:00:00
abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To assess the effectiveness of apical lordosating osteotomy (ALO) and minimal segment fixation through a posterior approach for correcting thoracic or thoracolumbar osteoporotic kyphosis (OK). SUMMARY OF BACKGROUND DATA:Current surgical options for OK involve a risk of com...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000170450.77554.bc
更新日期:2005-07-15 00:00:00
abstract:STUDY DESIGN:Longitudinal prospective study on a sample of 41 consecutive disc prosthesis patients, covering a postoperative time period of at least 2 years. OBJECTIVES:To document the rotational and translational range of segmental motion of patients instrumented with ProDisc II prostheses in the lumbar spine and to ...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/01.brs.0000224213.45330.68
更新日期:2006-07-01 00:00:00
abstract:STUDY DESIGN:Prospective study. OBJECTIVE:To identify the impact of laminoplasty on range of motion (ROM) and sagittal alignment of the cervical spine. SUMMARY OF BACKGROUND DATA:Cervical laminoplasty is an effective procedure decompressing multilevel spinal cord compression. Preoperative lordosis of the cervical spi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318158c573
更新日期:2007-11-01 00:00:00
abstract::A traditional teaching in orthopaedic surgery has been that, in cases of fusion for L4-5 discopathy or instability, one must include the lumbosacral joint. There is nothing in the literature to support this time-honored dictum. The senior author, among others, has rejected this concept; and, the authors are, therefore...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198904000-00022
更新日期:1989-04-01 00:00:00
abstract:STUDY DESIGN:A biomechanical study on a pneumatically controlled 7-axis spine simulator using Delron and human cadaveric spine models. OBJECTIVES:To compare the biomechanical properties of an anterior cervical extension plate with comparable-length anterior cervical plates. SUMMARY OF BACKGROUND DATA:Adjacent-level a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000186319.84883.e7
更新日期:2005-11-15 00:00:00
abstract:STUDY DESIGN:Experimental biomechanics of multilevel segments with 0, 1, 2, and 3 vertebral levels of polymethylmethacrylate augmentation. OBJECTIVE:To compare multilevel spinal segments with different numbers (0, 1, 2, and 3) of vertebral levels augmented with polymethylmethacrylate. SUMMARY OF BACKGROUND DATA:The s...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000207466.40955.31
更新日期:2006-04-01 00:00:00
abstract:STUDY DESIGN:Animal scoliosis model associated with syringomyelia. OBJECTIVE:To investigate the pathogenesis of scoliosis produced in dogs with kaolin-induced syringomyelia. SUMMARY OF BACKGROUND DATA:Kaolin injected into the cisterna magna produces basilar arachnoiditis, leading to hydrocephalus and syringomyelia. T...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199703150-00002
更新日期:1997-03-15 00:00:00
abstract:STUDY DESIGN:A case report of dorsally sequestered cervical disc herniation. OBJECTIVE:To present an unusual case of dorsally sequestered cervical disc herniation and to briefly review the literature on this condition. SUMMARY OF BACKGROUND DATA:There have been few reports of migration of cervical disc herniation to ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31815ce6c4
更新日期:2007-12-15 00:00:00
abstract:STUDY DESIGN:Sixty radiographs were measured on two separate occasions by three physicians using four different techniques to evaluate the reliability and reproducibility of the measurement of lumbar lordosis. OBJECTIVE:To evaluate clinical methods of measuring lumbar lordosis, determining intraobserver and interobser...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199607010-00008
更新日期:1996-07-01 00:00:00
abstract:STUDY DESIGN:In vitro cadaveric study. OBJECTIVE:The purpose of this study was to quantify the relative biomechanical protection resulting from "saving a level" in long spinal fusions. SUMMARY OF BACKGROUND DATA:"Saving levels" in spinal deformity surgery is desirable. Constructs with lowest instrumented vertebra (LI...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31821e1106
更新日期:2012-03-01 00:00:00
abstract:STUDY DESIGN:In vitro biomechanical testing of thoracic spine specimens using a standardized three-dimensional spine flexibility protocol. OBJECTIVES:To compare the mechanical stability of the intrapedicular and extrapedicular technique for pedicle screw placement. The hypothesis was that extrapedicular screw placemen...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000083280.72978.D1
更新日期:2003-08-15 00:00:00
abstract:STUDY DESIGN:The histology of lumbar intertransverse process spinal fusion was studied in an experimental model in rabbits. OBJECTIVES:To qualitatively and quantitatively analyze the sequential histology of spinal fusion using a previously validated animal model. SUMMARY OF BACKGROUND DATA:Few previous studies have d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199512150-00003
更新日期:1995-12-15 00:00:00