Brain metastases from esophageal cancer: A retrospective analysis of the outcome after surgical resection followed by radiotherapy.

Abstract:

:Brain metastases deriving from esophageal cancer are very rare with scarce data available concerning these patients' outcome. We, therefore, evaluated outcome after surgical resection followed by radiotherapy of brain metastasis from esophageal cancer.A retrospective analysis was conducted on consecutive patients undergoing resection of brain metastasis from esophageal cancer in 2 neuro-oncological centers between 2008 and 2018. Clinical and demographic data were retrieved from electronic patient charts. Post-treatment survival was calculated using Kaplan-Meier estimates.Twenty-five patients were identified. Treatment for primary disease comprised neo-adjuvant radio-chemotherapy followed by surgery (64.0%), surgery and adjuvant radio-chemotherapy (8.0%), radio-chemotherapy only (24.0%), and 1 patient receiving esophageal stenting only. Median time interval since initial diagnosis was 16 (range 0-110) months. All but 1 brain lesion were neurologically symptomatic and median Karnofsky performance score improved postoperatively from 70 to 80. After resection of brain metastases patients received whole-brain (n = 13 (52.0%)) or local fractionated (n = 9 (36.0%)) radiotherapy. In 2 patients adjuvant treatment was impeded by clinical deterioration; 1 patient refused radiotherapy. By the time of analysis 22 patients had died. Median survival after brain metastasis was 6 (95% CI 0.5-11.6) months.Survival after resection of metastasis from esophageal cancer is poor compared to other tumor entities. Nevertheless, resection of symptomatic brain metastases may improve clinical status in the context of a palliative concept.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Stavrinou P,Plambeck L,Proescholdt M,Ghadimi M,Goldbrunner R,Grau S

doi

10.1097/MD.0000000000016653

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

e16653

issue

34

eissn

0025-7974

issn

1536-5964

pii

00005792-201908230-00006

journal_volume

98

pub_type

杂志文章,多中心研究

相关文献

MEDICINE文献大全
  • Is surgery indicated for elderly patients with early stage nonsmall cell lung cancer, in the era of stereotactic body radiotherapy?

    abstract:BACKGROUND:The aim of this article is to assess the influence of comorbidities among elderly patients (at least 70 year old) undergoing surgery for early stage nonsmall cell lung cancer (NSCLC) and to explore the tolerability and efficacy of surgery in relation to stereotactic body radiotherapy (SBRT) in this patient p...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000005212

    authors: Nguyen NP,Godinez J,Shen W,Vinh-Hung V,Gorobets H,Thariat J,Ampil F,Vock J,Karlsson U,Chi A,International Geriatric Radiotherapy Group.

    更新日期:2016-10-01 00:00:00

  • How about the quality and recommendation on prevention, diagnosis, and treatment of HIV/AIDS guidelines developed by WHO: A protocol for systematic review.

    abstract:BACKGROUND:Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) has become a pandemic that has infected millions of people around the world and brings a tremendous economic burden. There are numerous guidelines for prevention, diagnosis, and treatment of HIV/AIDS published in recent years, but th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023638

    authors: Zhu Q,Fang P,Zhao Y,Dai D,Luo X

    更新日期:2020-12-24 00:00:00

  • Image quality of mixed convolution kernel in thoracic computed tomography.

    abstract::The mixed convolution kernel alters his properties geographically according to the depicted organ structure, especially for the lung. Therefore, we compared the image quality of the mixed convolution kernel to standard soft and hard kernel reconstructions for different organ structures in thoracic computed tomography ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005309

    authors: Neubauer J,Spira EM,Strube J,Langer M,Voss C,Kotter E

    更新日期:2016-11-01 00:00:00

  • Intestinal Infarction Caused by Thrombophlebitis of the Portomesenteric Veins as a Complication of Acute Gangrenous Appendicitis After Appendectomy: A Case Report.

    abstract::The clinical symptoms of pylephlebitis caused by acute appendicitis are varied and atypical, which leads to delayed diagnosis and poor outcomes. Here, we report a case of intestinal necrosis caused by thrombophlebitis of the portomesenteric veins as a complication of acute appendicitis after appendectomy. The patient ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001033

    authors: Tang R,Tian X,Xie X,Yang Y

    更新日期:2015-06-01 00:00:00

  • Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients.

    abstract::Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >300...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/MD.0000000000010419

    authors: Owen GI,Pinto MP,Retamal IN,Fernádez MF,Cisternas B,Mondaca S,Sanchez C,Galindo H,Nervi B,Ibañez C,Acevedo F,Madrid J,Peña J,Bravo ML,Maturana MJ,Cordova-Delgado M,Romero D,de la Jara N,Torres J,Rodriguez-Fernandez

    更新日期:2018-04-01 00:00:00

  • Nocardiosis of the central nervous system: experience from a general hospital and review of 84 cases from the literature.

    abstract::Central nervous system (CNS) nocardiosis is a rare disease entity caused by the filamentous bacteria Nocardia species. We present a case series of 5 patients from our hospital and a review of the cases of CNS nocardiosis reported in the literature from January 2000 to December 2011. Our results indicate that CNS nocar...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000000012

    authors: Anagnostou T,Arvanitis M,Kourkoumpetis TK,Desalermos A,Carneiro HA,Mylonakis E

    更新日期:2014-01-01 00:00:00

  • Upper gastrointestinal ectopic variceal bleeding treated with various endoscopic modalities: Case reports and literature review.

    abstract:RATIONALE:Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardiz...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005860

    authors: Park SW,Cho E,Jun CH,Choi SK,Kim HS,Park CH,Rew JS,Cho SB,Kim HJ,Han M,Cho KM

    更新日期:2017-01-01 00:00:00

  • Serum Ferritin Levels Are Positively Associated With Metabolically Obese Normal Weight: A Nationwide Population-Based Study.

    abstract::The purpose of this study was to examine the relationship between serum ferritin levels and metabolically obese normal weight (MONW) and to determine the appropriate cut-off value of serum ferritin for the prediction of clinical metabolic status in nonobese Korean adults. Data from 9411 participants in the fourth (200...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002335

    authors: Kim JW,Kim DH,Roh YK,Ju SY,Nam HY,Nam GE,Kim DW,Lee SH,Lee CW,Han K,Park YG

    更新日期:2015-12-01 00:00:00

  • A Rare Case of Disseminated Tuberculosis of the Bone Marrow in Systemic Lupus Erythematosus: Case Report.

    abstract::Patients with systemic lupus erythematosus (SLE) are susceptible to tuberculosis (TB), especially in endemic areas such as China. The variable and nonspecific clinical features of disseminated TB often leads to an erroneous or misdiagnosis. When a patient presents with TB of the bone marrow, the clinical condition is ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003552

    authors: Chen D,Yang Z,Yang Y,Zhan Z,Yang X

    更新日期:2016-05-01 00:00:00

  • Associations of plasma LP(a), Hcy and D-D levels with the subtype of ischemic cerebrovascular disease.

    abstract::The relevance of LP(a), Hcy, and D-D in ischemic cerebrovascular disease remains undefined. This study aimed to assess the associations of plasma LP(a), Hcy and D-D levels with the subtype of ischemic cerebrovascular disease.Patients with ischemic cerebrovascular disease admitted to the Taixing People's Hospital were ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014910

    authors: Tang Y,Geng D

    更新日期:2019-03-01 00:00:00

  • Complete clinical and functional recovery following low-dose methotrexate related paraparesis in a patient with compound c.1298A>C AND c.677C>T MTHFR polymorphism: A case report.

    abstract:RATIONALE:The mechanisms of action of MTX (methotrexate) in the treatment of RA (rheumatoid arthritis) and PsA (psoriatic arthritis) is related to its antifolic activity, due to the high affinity for enzymes that require folate cofactors as dihydrofolate reductase and to the anti-inflammatory activity derivated from th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013350

    authors: Saviola G,Abdi-Ali L,Sacco S,Comini L,Plewnia K,Rossi M,Orrico A

    更新日期:2018-12-01 00:00:00

  • Increased risk of appendectomy in patients with gastroesophageal reflux disease: A nested case-control study using a national sample cohort.

    abstract::The purpose of this study is to confirm and complement previous data regarding an association between gastroesophageal reflux disease and appendectomy.The Korean National Health Insurance Service-National Sample Cohort includes data from people ≥ 20 years old collected from 2002 to 2013. A total of 13,484 participants...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013700

    authors: Kim SY,Kim HJ,Lim H,Lim MS,Kim M,Choi HG

    更新日期:2018-12-01 00:00:00

  • Primary cutaneous anaplastic large-cell lymphoma: A case report.

    abstract:RATIONALE:Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface. PATIENT CONCERNS:This is the case of a 73-year-old man who r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009645

    authors: Abed K,Stopa Z,Siewert-Gutowska M

    更新日期:2018-01-01 00:00:00

  • Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up.

    abstract::Whipple disease (WD) is a rare multisystemic infection with a protean clinical presentation. The central nervous system (CNS) is involved in 3 situations: CNS involvement in classic WD, CNS relapse in previously treated WD, and isolated CNS infection. We retrospectively analyzed clinical features, diagnostic workup, b...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000010

    authors: Compain C,Sacre K,Puéchal X,Klein I,Vital-Durand D,Houeto JL,De Broucker T,Raoult D,Papo T

    更新日期:2013-11-01 00:00:00

  • Assessment of mental health among nursing staff at different levels.

    abstract::To assess the mental health of nurses and to find the post responsibility and psychological status of clinical nurses.A total of 447 nursing staff at different levels in a teaching hospital was assessed by nursing post responsibility scale and mental symptom checklist (SCL-90) then compared with each other. The study ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019049

    authors: Du ML,Deng WX,Sun W,Chien CW,Tung TH,Zou XC

    更新日期:2020-02-01 00:00:00

  • Olfactory function and quality of life following microscopic endonasal transsphenoidal pituitary surgery.

    abstract::Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000465

    authors: Wang S,Chen Y,Li J,Wei L,Wang R

    更新日期:2015-01-01 00:00:00

  • Role of injection laryngoplasty in preventing post-stroke aspiration pneumonia, case series report.

    abstract:INTRODUCTION:Injection laryngoplasty is a common procedure for patients with vocal fold dysfunction, but the literature on its benefits has been mainly focused on those related to structural lesions or laryngeal nerve involvement. Stroke patients may be at increased risk of aspiration due to insufficient vocal fold mot...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019220

    authors: Han YJ,Jang YJ,Park GY,Joo YH,Im S

    更新日期:2020-02-01 00:00:00

  • Erratum: Polysplenia Syndrome With Splenic and Skeletal Muscle Metastases From Thyroid Carcinoma Evaluated by FDG PET/CT: Case Report and Literature Review: A CARE-Compliant Article: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000002532.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000494756.80250.4a

    authors:

    更新日期:2016-08-26 00:00:00

  • Risk factors of uveitis in ankylosing spondylitis: An observational study.

    abstract:BACKGROUND:Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004233

    authors: Sun L,Wu R,Xue Q,Wang F,Lu P

    更新日期:2016-07-01 00:00:00

  • Bilateral stellate ganglion block for migraine: A case report.

    abstract:RATIONALE:Migraine is a recurrent, disabling neurovascular headache disorder. The patient's quality of life can be severely impaired by migraine attacks. Stellate ganglion block (SGB) can be used to relieve pain in the head, neck, and upper extremities. In the present cases, we performed SGB in 2 patients with migraine...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020023

    authors: Moon S,Lee J,Jeon Y

    更新日期:2020-05-01 00:00:00

  • CTLA-4 rs5742909 polymorphism and cervical cancer risk: A meta-analysis.

    abstract:BACKGROUND:Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000019433

    authors: Hu S,Pu D,Xia X,Guo B,Zhang C

    更新日期:2020-03-01 00:00:00

  • Neutrophil-lymphocyte ratio, gamma-glutamyl transpeptidase, lipase, high-density lipoprotein as a panel of factors to predict acute pancreatitis in pregnancy.

    abstract::Acute pancreatitis in pregnancy (APIP) is a rare but dangerous complication. APIP has common symptoms with acute abdomen. Assessment of an acute abdomen is more complicated during pregnancy because the gravid uterus could mask most of symptomatic signs. It has been a challenge to diagnose APIP by physical examination ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011189

    authors: Zhang L,Wang Y,Han J,Shen H,Zhao M,Cai S

    更新日期:2018-06-01 00:00:00

  • Effects of tumor origins and therapeutic options on the prognosis of hepatic neuroendocrine tumors: A retrospective study.

    abstract:ABSTRACT:Hepatic neuroendocrine tumors (HNETs) are uncommon neoplasms that can be subdivided into 2 types: primary and metastatic HNETs. Due to its rarity, heterogeneity and complexity, the diagnosis, treatment modalities and prognosis are still controversial.This retrospective study reviewed the effects of tumor origi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023655

    authors: Jiao X,Luan W,Peng X,Liu L,Zhang L,Zhou L

    更新日期:2020-12-18 00:00:00

  • Different clinical characteristics in sporadic young-age onset colorectal cancer.

    abstract::The incidence of colorectal cancer (CRC) is increasing in young-age patients, but the clinical history is not established. Authors analyzed the clinical characteristics of young-age onset CRC to support basic information for setting treatment policies.Between January 2006 to January 2014, 100 CRC patients diagnosed at...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004840

    authors: Lee J,Kim IH,Kim JS,Kim SW,Kim JG,Oh ST,Kang WK,Lee MA

    更新日期:2016-09-01 00:00:00

  • The prediction potential of neutrophil-to-lymphocyte ratio for the therapeutic outcomes of programmed death receptor-1/programmed death ligand 1 inhibitors in non-small cell lung cancer patients: A meta-analysis.

    abstract:BACKGROUND:Programmed death receptor-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors have been demonstrated to improve the prognosis of patients with advanced non-small cell lung cancer (NSCLC) compared with chemotherapy. However, there were still some non-responders. Thus, how to effectively screen the responder...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000021718

    authors: Huang Y,Shen A

    更新日期:2020-08-21 00:00:00

  • Fractures as a suicidal behavior risk factor: A nationwide population-based cohort study.

    abstract::This study aimed to evaluate the association between fracture history and sequential risk of suicidal behavior.A total of 82,804 patients with fractures and 82,804 control subjects without fractures were matched. The influence of fractures on the risk of suicidal behavior-related hospital visit was analyzed using a Co...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014148

    authors: Tsai CH,Cheng WJ,Muo CH,Lin TL

    更新日期:2019-01-01 00:00:00

  • An Attempt to Evaluate Selected Aspects of "Bone-Fat Axis" Function in Healthy Individuals and Patients With Pancreatic Cancer.

    abstract::Recently, much attention has been paid to a potential biochemical cross-talk between the metabolism of the adipose tissue (AT) and bone (marrow), termed "bone-fat axis." We hypothesized that selected substances, participating in this "dialog," are associated with body mass and peripheral trafficking of bone marrow-der...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001303

    authors: Blogowski W,Dolegowska K,Deskur A,Dolegowska B,Starzyńska T

    更新日期:2015-08-01 00:00:00

  • Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma.

    abstract::The present study aimed to analyze and compare the prognostic performances of the Japanese Ministry of Health and Welfare (JMHW) score, the Korean Society on Thrombosis and Hemostasis (KSTH) score, the International Society on Thrombosis and Haemostasis (ISTH) score, the Japanese Association for Acute Medicine (JAAM) ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011912

    authors: Lee DH,Lee BK,Jeung KW,Park JS,Lim YD,Jung YH,Lee SM,Cho YS

    更新日期:2018-08-01 00:00:00

  • Interactive associations of sex and hyperlipidemia with calcific tendinitis of the shoulder in Taiwanese adults.

    abstract::Calcific tendinitis (CT) of the shoulder is a painful disorder usually identified in individuals aged 40 and 60 years. The estimated global prevalence of CT is 2.7% to 36%. We examined the association of hyperlipidemia and sex with CT of the shoulder using Taiwan Biobank (TWB) and the National Health Insurance Researc...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023299

    authors: Lin CC,Nfor ON,Su CL,Hsu SY,Tantoh DM,Liaw YP

    更新日期:2020-11-13 00:00:00

  • Are gastric hyperplastic polyps an additional manifestation in celiac disease?: Results from a retrospective study.

    abstract::Gastric polyps are frequently reported in patients undergoing upper endoscopic procedures. In this retrospective study, the association between hyperplastic polyps and celiac disease in Northern Sardinia was estimated.Age, gender, body mass index, and medications taken in the 2 preceding months, including proton-pump ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005923

    authors: Dore MP,Pes GM,Rocchi C,Loria MF,Soro S,Bassotti G

    更新日期:2017-02-01 00:00:00