Abstract:
INTRODUCTION:We aimed to investigate the impact of radiation treatment in early-stage triple negative breast cancer (TNBC). METHODS:Patients with early stage (T1-3, N0-2, M0) TNBC were identified using the New Zealand breast cancer register. The outcomes of local recurrence (LRFR), local recurrence free survival (LRFS), loco-regional recurrence free rate (LRRFR), loco-regional recurrence free survival (LRRFS), breast cancer specific survival (BCSS), metastasis free (MFS) and overall survival (OS) were determined. Predefined univariate and multivariate cox regression analyses were used to explore associations between known prognostic and treatment factors. RESULTS:1209 patients were identified with a median follow-up of 3.88 years. The majority were post- menopausal. The mean tumour size was 26mm, the majority had grade III disease and a third were node positive. 625 patients had mastectomy and 584 had breast conservation surgery (BCS). 92% of BCS and 38% of mastectomy patients received radiation. 67% received adjuvant chemotherapy. The 5 year OS was 77.6% (95% CI 74.6-80.2), 5 year BSS was 82.1% (95%CI 79.1-84.7), 5 year LRRFS was 73.9% (95% CI 73.87-73.93), 5 year LRFS was 75.4 (75.37-75.43) and the 5 year LRFR was 92.4% (95% CI 90.6-94.2). The significant prognostic/predictive factors for OS were adjuvant radiation treatment, chemotherapy, T stage, lymph node involvement and lympho-vascular space invasion. Results were similar for BSS, DMFS, LRFS and LRRFS except that LVSI was not significantly associated with BCSS, LRFS or LRRFS. When analysed by surgical type, in the WLE group, radiation was found to be significantly associated with improvement in all outcomes. In mastectomy group, radiation was not found to be significant for BCSS, LRFS, LRRFS or OS. CONCLUSION:Radiation treatment is significantly associated with improved outcomes in early stage TNBC. This argues against the hypothesis that TNBC has inherent radiation resistance.
journal_name
J Med Imaging Radiat Oncoljournal_title
Journal of medical imaging and radiation oncologyauthors
Dixit A,Frampton C,Davey V,Robinson B,James Mdoi
10.1111/1754-9485.12933subject
Has Abstractpub_date
2019-10-01 00:00:00pages
698-706issue
5eissn
1754-9477issn
1754-9485journal_volume
63pub_type
杂志文章abstract:BACKGROUND:Respiratory-gated radiotherapy (RGRT) is used in several centres around the world. However, there is continuing controversy regarding the benefit of this technique. The aims of this study are to quantify the dosimetric benefits and the potential predictive factors. METHODS:Thirty-four consecutive patients w...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 临床试验,杂志文章
doi:10.1111/1754-9485.12088
更新日期:2013-12-01 00:00:00
abstract::Adenomyomatosis is a relatively common abnormality of the gall bladder, with a reported incidence of between 2.8 and 5%. Although mainly confined to the adult study group, a number of cases have been reported in the paediatric study group. It is characterized pathologically by excessive proliferation of the surface ep...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1673.2008.01926.x
更新日期:2008-04-01 00:00:00
abstract::This study aimed to describe the radiotherapy (RT) management and subsequent outcome in a cohort of patients with newly diagnosed glioma. Treatment details were obtained via a questionnaire completed by neurosurgeons, radiation and medical oncologists who treated patients diagnosed with glioma in Victoria during 1998-...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2009.02072.x
更新日期:2009-06-01 00:00:00
abstract:INTRODUCTION:Marker clips are commonly deployed at the site of a percutaneous breast biopsy. Studies have shown that displacement of the clip from the site of deployment is not uncommon. The objective of this study was to determine how much 'migration' could be seen with fixed structures within the breast tissue across...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12327
更新日期:2015-10-01 00:00:00
abstract::Pericardial involvement of multiple myeloma is a rare and late-stage complication, with only a few cases reported in the literature. PET/CT has demonstrated a growing role in the diagnosis and follow-up of patients with multiple myeloma. We present a case of pericardial multiple myeloma in a patient with relapsed/refr...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12992
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to investigate the prognostic utility and reproducibility of a qualitative 5-point 18-fluorodeoxyglucose (FDG)-PET primary visual score (PVS) in patients with oesophageal and gastro-oesophageal junction (GOJ) cancer. METHODS:This was a retrospective review of patients with hi...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.13110
更新日期:2020-10-15 00:00:00
abstract::Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare form of T-cell lymphoma, recently linked to the use of certain types of breast implants. Although rare, BIA-ALCL is being increasingly recognised and radiologists can play an important role in its early diagnosis. BIA-ALCL is thought to be r...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12905
更新日期:2019-10-01 00:00:00
abstract::The aim of this study was to evaluate our experience with the retrievable Cook Celect inferior vena cava (IVC) filter (William Cook, Europe) with regard to insertion, efficiency, ease of retrieval, and any associated complications. A retrospective review was performed of 115 patients (41 female, 74 male, mean age 47.9...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2009.02039.x
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:A unified and logical system of descriptors for diagnostic imaging examinations and procedures is a desirable resource for radiology in Australia and New Zealand and is needed to support core activities of RANZCR. Existing descriptor systems available in Australia and New Zealand (including the Medicare DI...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12191
更新日期:2014-08-01 00:00:00
abstract::A number of benign bone tumours can be treated with curettage and packing with either bone cement or graft. It is essential that the radiologist be familiar with both the normal and abnormal post-operative imaging appearance of these treated tumours. Through the use of numerous imaging examples, we aim to provide a pi...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12329
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:A 2005 survey of practices indicated limited use of three-dimensional (3D) imaging modalities and planning methods in cervix cancer brachytherapy in Australia and New Zealand. However, advancing technologies and published recommendations are influencing change. This survey aims to identify both changes in ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2010.02185.x
更新日期:2010-08-01 00:00:00
abstract::The aims of this study were to investigate whether intrafraction prostate motion can affect the accuracy of online prostate positioning using implanted fiducial markers and to determine the effect of prostate rotations on the accuracy of the software-predicted set-up correction shifts. Eleven patients were treated wit...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1440-1673.2008.02006.x
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:Invasive lobular cancer (ILC) is an important contributor to false negative mammography. This study aims to assess the value of digital mammography and to identify imaging features that could assist the radiologist to suggest the diagnosis of ILC prior to biopsy. METHODS:Three hundred sixty-one cases of p...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12080
更新日期:2014-02-01 00:00:00
abstract:INTRODUCTION:This survey aimed to assess the use of image-guided radiotherapy (IGRT) within New Zealand (NZ) and evaluate the quality of IGRT delivery. METHOD:All nine centres in NZ were invited to participate in an online survey in November 2015. Questions were asked on type of IGRT technologies available, IGRT use b...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12682
更新日期:2018-04-01 00:00:00
abstract::Uterine malignancies account for the majority of gynaecologic cancers. Different treatment options are available depending on histology, disease grade and stage. Hysterectomy is the most frequent surgical procedure. Chemotherapy and radiation therapy (CRT) represents the preferred therapeutic choice for locally advanc...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/1754-9485.12624
更新日期:2017-12-01 00:00:00
abstract::Many artefacts can mimic pulmonary emboli (PE) on CT pulmonary angiography (CTPA), most commonly in the peripheral pulmonary arteries (PA's). We describe flow-related artefact mimicking PE in the central PA's of two patients, both with pulmonary arterial hypertension (PAH). To our knowledge, this is the first report o...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12893
更新日期:2019-08-01 00:00:00
abstract::Since the outbreak of Coronavirus disease 2019 (COVID-19) in China, many researchers have reported the chest CT manifestations of COVID-19 pneumonia. High-resolution CT (HRCT) of the lung can provide important clues to understand the progressive behaviour of COVID-19 pneumonia. This pictorial essay discusses the early...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.13139
更新日期:2021-01-24 00:00:00
abstract::The 'scimitar sign' on plain chest radiograph is most commonly attributed to the presence of a scimitar vein, which is a variant of partial anomalous pulmonary venous drainage (PAPVD). An anomalous unilateral single pulmonary vein (AUSPV) is a very rare anomaly, albeit benign, which can also present with the scimitar ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1754-9485.2012.02385.x
更新日期:2012-06-01 00:00:00
abstract:INTRODUCTION:Interventional Radiology procedures can provoke anxiety and may be painful. Current practice, Radiologist Controlled Sedation (RCS), involves titrating aliquots of midazolam and fentanyl to patient response but underdosing and overdosing may occur. This study tests a new method of titrating sedation/analge...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,随机对照试验
doi:10.1111/1754-9485.12817
更新日期:2018-12-01 00:00:00
abstract::The retroperitoneal space is made up of multiple communicating compartments. Here we detail an unusual case of ectopic gas almost exclusively isolated to the properitoneal space, a space in communication with the retroperitoneum. This case is a reminder that when extraperitoneal gas is identified, the retroperitoneal ...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12820
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Evidence that Deep Inspiration Breath Hold (DIBH) can reduce cardiac dose during left-sided breast radiation therapy (RT) has led to widespread uptake of this technology. There is a paucity of published information documenting the impact of this technique on the patient's treatment experience. The aim of t...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12795
更新日期:2018-12-01 00:00:00
abstract::CT imaging for lung cancer screening requires low dose technique. Low dose CT chest imaging is associated with an increased risk of artefacts, such as increased noise. We present a case where an artefact from the low dose technique lead to a lung cancer being erroneously reported as a benign hamartoma. ...
journal_title:Journal of medical imaging and radiation oncology
pub_type:
doi:10.1111/1754-9485.13086
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Cone-beam computed tomography (CBCT) is a valuable image-guidance tool in radiation therapy (RT). This study was initiated to assess the accuracy of CBCT for quantifying non-small cell lung cancer (NSCLC) tumour volumes compared to the anatomical 'gold standard', CT. Tumour regression or progression on CBC...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12551
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The goal of this initial clinical study was to test a new positron emission/tomography imager and biopsy system (PEM/PET) in a small group of selected subjects to assess its clinical imaging capabilities. Specifically, the main task of this study is to determine whether the new system can successfully be u...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2010.02230.x
更新日期:2011-02-01 00:00:00
abstract:INTRODUCTION:To report long-term prostate-specific antigen (PSA) and toxicity outcomes for patients with localised prostate cancer treated with Iodine-125 permanent implantation at a single Australian centre. METHODS:Between September 1994 and November 2007, 207 patients at Sir Charles Gairdner Hospital with localised...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12453
更新日期:2016-08-01 00:00:00
abstract:INTRODUCTION:Single- and multiple-fraction external beam radiotherapy (SFX-EBRT and MFX-EBRT) are palliative treatment options for localized metastatic bone pain. MFX is the preferred choice in many developed countries. Evidence shows little difference in how effectively SFX and MFX reduce pain. However, SFX is associa...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.12467
更新日期:2016-10-01 00:00:00
abstract::The study reports on the evolution of the Australian radiologist relative value unit (RVU) model of measuring radiologist reporting workloads in teaching hospital departments, and aims to outline a way forward for the development of a broad national safety, quality and performance framework that enables value mapping,...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2009.02094.x
更新日期:2009-10-01 00:00:00
abstract:INTRODUCTION:Since its onset in the spring of 2009, the H1N1 pandemic has kept health-care professionals busy worldwide. Even though it often causes respiratory tract illness, reports describing the radiological manifestations in infected children are few. The purpose of this study was twofold: to review the chest radi...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/j.1754-9485.2011.02264.x
更新日期:2011-06-01 00:00:00
abstract::Establishing and maintaining venous access forms an increasing proportion of the workload in interventional radiology. Several patient groups require medium-term to long-term venous catheters for a variety of purposes, including chemotherapy, long-term antimicrobials, parenteral nutrition, short-term access for haemod...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1673.2007.01904.x
更新日期:2008-02-01 00:00:00
abstract::We report the case of who has been hospitalized complaining about fever in the last 4 days. Laboratory data revealed lymphocytopenia and leucopenia with an elevation of C-reactive protein and positive real-time reverse transcription-polymerase chain reaction (RT-PCR). Six days before this hospitalization, when the pat...
journal_title:Journal of medical imaging and radiation oncology
pub_type: 杂志文章
doi:10.1111/1754-9485.13099
更新日期:2020-10-01 00:00:00