Current status and applications of genome-scale metabolic models.

Abstract:

:Genome-scale metabolic models (GEMs) computationally describe gene-protein-reaction associations for entire metabolic genes in an organism, and can be simulated to predict metabolic fluxes for various systems-level metabolic studies. Since the first GEM for Haemophilus influenzae was reported in 1999, advances have been made to develop and simulate GEMs for an increasing number of organisms across bacteria, archaea, and eukarya. Here, we review current reconstructed GEMs and discuss their applications, including strain development for chemicals and materials production, drug targeting in pathogens, prediction of enzyme functions, pan-reactome analysis, modeling interactions among multiple cells or organisms, and understanding human diseases.

journal_name

Genome Biol

journal_title

Genome biology

authors

Gu C,Kim GB,Kim WJ,Kim HU,Lee SY

doi

10.1186/s13059-019-1730-3

subject

Has Abstract

pub_date

2019-06-13 00:00:00

pages

121

issue

1

eissn

1474-7596

issn

1474-760X

pii

10.1186/s13059-019-1730-3

journal_volume

20

pub_type

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