Abstract：
BACKGROUND:Neoadjuvant therapy is recommended for patients with borderline-resectable pancreatic cancer (BRPC). In this study, we compare survival outcomes of neoadjuvant therapy with upfront surgery. METHODS:From January 2011 to June 2016, 1415 patients underwent treatments for pancreatic cancer in Samsung Medical Center. Among them, 112 (7.9%) patients were categorized as BRPC by the NCCN 2016 guideline. They were classified by type of initial treatments into neoadjuvant group (NA, N.=26) and upfront surgery group (US, N.=86). RESULTS:The median survival duration of all patients was 18.3 months. Patients in the NA group had more T4 disease than those in the US group (38.5% in NA versus 15.1% in the US group; P=0.010). Arterial involvement was more frequent in the NA group (42.3% versus 15.1%; P=0.003). In the NA group, ten (38.5%) patients underwent surgery, and seven of them had complete R0 resection. In the US group, 83 (96.5%) patients received radical surgery, and 42 (48.8%) had R0 resection. In survival analysis according to intent to treat, the overall two-year survival rate was 51.1% in the US group and 36.7% in the NA group (P=0.001). However, among patients who underwent surgery (N.=96), the two-year overall survival rate was not significantly different between the two groups (P=0.089). According to involved vessels, the survival rate was not different between patients with arterial or both arterial and venous involvement and in patients with only venous involvement (P=0.649). CONCLUSIONS:It is necessary to demonstrate the efficacy of neoadjuvant therapy and to standardize the regimens through large-scale, multicenter, randomized controlled studies.
journal_name
Minerva Chirjournal_title
Minerva chirurgicaauthors
Han S,Choi SH,Choi DW,Heo JS,Han IW,Park DJ,Ryu Ydoi
10.23736/S0026-4733.19.07958-6subject
Has Abstractpub_date
2020-02-01 00:00:00pages
15-24issue
1eissn
0026-4733issn
1827-1626pii
S0026-4733.19.07958-6journal_volume
75pub_type
杂志文章abstract：:Despite many guidelines issued by national and professional societies, a detailed literature survey between the late 1940s and 2010 clearly demonstrates that several aspects of pneumothorax pathogenesis and treatment still remain controversial. Related to pathogenesis of primary pneumothorax, the current manuscript hi...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2011-08-01 00:00:00
abstract：:A case of aneurysm of the hepatic artery associated with aneurysm of the abdominal artery in fissuration is discussed. The indications, possibilities and limits of exclusion or removal of the aneurysm without reconstructing the main artery axis in the treatment of cases involving the hepatic artery are examined in the...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1978-01-15 00:00:00
abstract：:The authors report a retrospective study of four patients treated for sigmoid volvulus at the Clinica Chirurgica II of IRCCS Policlinico S. Matteo of Pavia between April 1974 and June 1989. They are collected from a series of 74 consecutive operations for colonic obstruction not related to hernias of the inguinal-crur...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1993-05-31 00:00:00
abstract：:We report a case of diffuse diverticulosis of the gallbladder in a 32 year old patient, who presents epigastric pains and decayed general conditions. With the suspicion of a primitive tumor of the gallbladder, we make a cholecystectomy and the intraoperative histological examination shows a "diffuse diverticulosis of ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:Three cases of diverticulum of the IV duodenal portion are presented. The Authors, after having summarized the general features of the duodenal diverticula, remembered the rareness of the ones of its fourth portion, describe the clinical cases and conclude synthetizing the main indications to this type of surgery: com...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-09-15 00:00:00
abstract：:Late thrombosis of inserted prosthetic grafts for arterial reconstructive surgery is one of the most frequent late complication. Its incidence is influenced by many factors: hemodynamic conditions, quality of run-in and run-off, technical aspects of the primary repair. Progressive arteriosclerosis in femoral vessels w...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1989-03-31 00:00:00
abstract：:Between January 1989 and December 1994 we accomplished 130 CT-guided transthoracic fine needle aspirations (FNA) in 120 patients. Ten patients underwent a second FNA because of the negativity and doubts of the first. Diagnosis was targeted in 114 (95%) patients and 89% showed cytological evidence of malignancy. FNA-CT...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Peri-inguinal and Para-inguinal hernias are included in the group of lateral ventral hernias and must be distinguished from Spigelian and intraparietal ascending inguinal hernias. Peri-inguinal hernia is very unusual in its location and development. Non one similar case has been reported in literature. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1991-04-30 00:00:00
abstract：:A series of cases of acute pancreatitis treated between 1-XI-1972 and 1-XI-1975 is presented. A division is made between cases acute ab initio and postoperative pancreatitis, the latter further subdivided into pancreatic necroses, oedemas, and slight affections. The question of diagnosis is examined and elements indic...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1976-10-31 00:00:00
abstract：:A case of spontaneous oesophageal rupture or Boerhaave syndrome is described. The absence of the typical initial vomiting together with a clinical picture that successively indicated repeated myocardial infarction, pancreatitis and pulmonary abscess delayed diagnosis by 4 days, after which emergency thoracotomy, perfo...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:In the present study the A. try to assess the usefulness of ultrasound in detecting blending risk in portal hypertension. Endoscopic and sonographic findings of 35 cirrhotic patients with esophageal varices were compared to a control group of 27 hepatopathy patients without portal hypertension, observed in the same de...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The authors report a case of granular cell tumor of the breast arising in a 38-year old man. Preoperative diagnosis was of breast carcinoma. However, frozen sections showed the benign nature of the tumour. It is important to identify this lesion as, in spite of a clinical and mammographic similarity with carcinoma, it...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:High resolution magnetic resonance cholangiopancreatography (MRCP) is a non invasive imaging modality for depicting the pancreatobiliary tree. It can demonstrate dilation, stenosis and intraductal filling defects of both the biliary and the pancreatic duct. The imaging quality of high resolution MRCP is exce...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the efficacy and safety of biliary-intestinal bypass in severely obese subjects (Body Mass Index > 35). METHODS:From January to December 1999, 23 patients (8 men and 15 women, mean age 36.6 years: range 20-51) affected with primary morbid obesity (BMI >40: range 40.1-6...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:In Italy 250,000 subjects every year are affected by malignant tumors, causing 150,000 deaths/year. The global index (statistic prevalence) of oncological patients, either at first diagnosis, or restored to health or under treatment, aggregates 1 million and 500 thousand individuals. During his whole lifetime, every m...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2003-04-01 00:00:00
abstract：AIM:Ischemic gastritis is poorly known by physicians and is often fatal if not correctly diagnosed. Here, we report on the clinical, endoscopic and imaging features and treatment outcomes for five ischemic gastritis patients. METHODS:This was a retrospective, single-centre study of patients treated for ischemic gastri...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:Gastro-intestinal foreign bodies are a by no means rare event in surgery and in the USA mortality is about 1500 people per annum. The surgical treatment of foreign bodies in the alimentary tract is reported here. Certain cases of voluntary ingestion in mental patients are reported, comparing personal experience with t...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate safety, feasibility and short-term outcomes of our first 70 consecutive patients treated by robotic-assisted liver resection after a reversal proctoring between a high HPB volume centre and our well-trained center in minimally invasive General Surgery. Six surgeons were ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：10.23736/S0026-4733.18.07651-4
更新日期：2018-10-01 00:00:00
abstract：:The extreme variations with which atherosclerotic disease presents as regards progression index, arterial bed localization frequency, malignity and invasiveness in different ages and often as regards different anatomopathological aspects characterizing the formation and course of the primary lesion, mean that there ar...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1977-04-15 00:00:00
abstract：:Phlebology has made considerable efforts to free itself from empiricism in recent years. Careful scientific methods have enabled previously unhoped-for results to be obtained in very widespread and debilitating diseases. New and in some cases revolutionary concepts are described, whose application presupposes the exis...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1975-10-31 00:00:00
abstract：:A case of endothoracic goitre with crossed, left-right, retrovascular, retro-tracheo-oesophageal migration is used as the basis for pathogenetic and diagnostic discussion and for stressing the surgical importance of correct topographic and migratory classification of each form. ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1977-02-28 00:00:00
abstract：:Deep venous thrombosis is a quite frequent pathology with a high degree of morbidity and death-rate. Two are the main problems of this disease: the risk of pulmonary embolism and outcome of a post-thrombotic syndrome, leading patients to infirmity. The patients max exposed to the risk of deep venous thrombosis are the...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:This paper is a critical review of the clinical records of 20 patients who underwent a Transduodenal Sphincteroplasty (PSP), from October 1990 to January 1992 at our Department (General Surgery). The age was 64.9 (14.2) years (mean and standard deviation), but 14 (70%) of those patients were older than 60 (range: 63 t...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:The efficacy of two methods of orthograde lavage preparation in elective colorectal surgery was tested in 133 consecutive patients: the results obtained with whole gut irrigation (50 patients, group A) were compared with the results of oral lavage solution (83 patients, group B). All patients received a parenteral ass...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Two cases of cardiac wounds in association with acute anaemia and acute cardiac tamponade respectively are presented. The statistical and, more particularly, the diagnostic factors involved are discussed. Stress is laid on the measurement of CVP along with pericardiocentesis. Correct interpretation of the data furnish...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1978-11-15 00:00:00
abstract：:Open Nissen fundoplication has been established as an effective treatment in the management of gastroesophageal reflux disease (GORD). Progress in minimally invasive surgery has given the chance of performing laparoscopic Nissen fundoplication. The short-term results are encouraging and its outcome promising. The need...
journal_title：Minerva chirurgica
pub_type： 杂志文章,评审
doi：
更新日期：2001-08-01 00:00:00
abstract：:The Authors present their personal experience in the surgical treatment, using the Shouldice modified method, of 85 cases of patients suffering from inguinal hernia. The rarity of general and local complications and the relatively low percentage of relapse, if compared with other surgical methods, testify to the valid...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:The Authors perform a retrospective study on the incidence of postoperative jaundice in a selected group of 2060 patients, who underwent operations of general or vascular surgery. The incidence of jaundice in the postoperative period appears to be quite high in vascular surgery: out of 96 patients became jaundiced, 78...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1980-06-30 00:00:00
abstract：:A rare case of gastric schwannoma is reported. A 36-year-old woman whose endoscopy showed a mucosa tumor, biopsy findings were suggestive for leiomyoma. Diagnosis was made only with postoperative histology that revealed the benign schwannoma. Immunohistochemical staining showed positivity for S-100 protein and the neu...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:A case series of 5 male patients afflicted with breast carcinoma is reported. The Authors describe symptomatology, diagnostic iter, principles of surgical treatment and results. Underlined is the wider surgical demolition in male breast cancer in comparison with females, even if natural history and biological conduct ...
journal_title：Minerva chirurgica
pub_type： 杂志文章
doi：
更新日期：1990-09-15 00:00:00
