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Autoimmune and inflammatory K+ channelopathies in cardiac arrhythmias: Clinical evidence and molecular mechanisms.

Abstract：

:Cardiac K+ channelopathies account for a significant proportion of arrhythmias and sudden cardiac death (SCD) in subjects without structural heart disease. It is well recognized that genetic defects are key factors in many cases, and in practice, the term cardiac channelopathies currently coincides with inherited cardiac channelopathies. However, mounting evidence demonstrate that not only genetic alterations but also autoimmune and inflammatory factors can cause cardiac K+-channel dysfunction and arrhythmias in the setting of a structurally normal heart. In particular, it has been demonstrated that specific autoantibodies as well as inflammatory cytokines can modulate expression and/or function of different K+ channels in the heart, resulting in a disruption of the cardiac action potential and arrhythmias/sudden cardiac death. Awareness about the existence of these newly recognized forms is essential to identify and adequately manage affected patients. In the present review, we focus on autoimmune and inflammatory K+ channelopathies as a novel mechanism for cardiac arrhythmias and analyze the recent advancements in this topic, providing complementary basic, clinical, and population health perspectives.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Capecchi PL,Laghi-Pasini F,El-Sherif N,Qu Y,Boutjdir M,Lazzerini PE

doi

10.1016/j.hrthm.2019.02.017

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

1273-1280

issue

8

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(19)30139-0

journal_volume

16

pub_type

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