Abstract:
:Sialic acid is associated with glycoproteins and gangliosides of eukaryotic cells. It regulates various molecular interactions, being implicated in inflammation and cancer, where its expression is regulated by sialyltransferases and sialidases. Angiogenesis, the formation of new capillaries, takes place during inflammation and cancer, and represents the outcome of several interactions occurring at the endothelial surface among angiogenic growth factors, inhibitors, receptors, gangliosides and cell-adhesion molecules. Here, we elaborate on the evidences that many structures involved in angiogenesis are sialylated and that their interactions depend on sialic acid with implications in angiogenesis itself, inflammation and cancer. We also discuss the possibility to exploit sialic acid as a target for the development of novel antiangiogenic drugs.
journal_name
Future Med Chemjournal_title
Future medicinal chemistryauthors
Chiodelli P,Urbinati C,Paiardi G,Monti E,Rusnati Mdoi
10.4155/fmc-2018-0298subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2835-2854issue
24eissn
1756-8919issn
1756-8927journal_volume
10pub_type
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journal_title:Future medicinal chemistry
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pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Future medicinal chemistry
pub_type: 杂志文章,评审
doi:10.4155/fmc-2016-0013
更新日期:2016-04-01 00:00:00
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journal_title:Future medicinal chemistry
pub_type: 杂志文章,评审
doi:10.4155/fmc-2018-0208
更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
doi:10.4155/fmc.10.300
更新日期:2011-02-01 00:00:00
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doi:10.4155/fmc-2017-0154
更新日期:2018-03-01 00:00:00
abstract::Spinal muscular atrophy (SMA) is an inherited neurodegenerative disease that results in progressive dysfunction of motor neurons of the anterior horn of the spinal cord. SMA is caused by the loss of full-length protein expression from the survival of motor neuron 1 (SMN1) gene. The disease has a unique genetic profile...
journal_title:Future medicinal chemistry
pub_type: 杂志文章,评审
doi:10.4155/fmc.12.107
更新日期:2012-09-01 00:00:00
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journal_title:Future medicinal chemistry
pub_type: 杂志文章,评审
doi:10.4155/fmc.14.125
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.4155/fmc.13.126
更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.4155/fmc.12.25
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
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pub_type: 面试
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更新日期:2017-10-01 00:00:00
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