Abstract:
:Cap analogs are chemically modified derivatives of the unique cap structure present at the 5´ end of all eukaryotic mRNAs and several non-coding RNAs. Until recently, cap analogs have served primarily as tools in the study of RNA metabolism. Continuing advances in our understanding of cap biological functions (including RNA stabilization, pre-mRNA splicing, initiation of mRNA translation, as well as cellular transport of mRNAs and snRNAs) and the consequences of the disruption of these processes - resulting in serious medical disorders - have opened new possibilities for pharmaceutical applications of these compounds. In this review, the medicinal potential of cap analogs in areas, such as cancer treatment (including eIF4E targeting and mRNA-based immunotherapy), spinal muscular atrophy treatment, antiviral therapy and the improvement of the localization of nucleus-targeting drugs, are highlighted. Advances achieved to date, challenges, plausible solutions and prospects for the future development of cap analog-based drug design are described.
journal_name
Future Med Chemjournal_title
Future medicinal chemistryauthors
Ziemniak M,Strenkowska M,Kowalska J,Jemielity Jdoi
10.4155/fmc.13.96subject
Has Abstractpub_date
2013-06-01 00:00:00pages
1141-72issue
10eissn
1756-8919issn
1756-8927journal_volume
5pub_type
杂志文章,评审abstract::Existing therapies for allergic asthma are far from perfect: the global prevalence of disease increases despite them and they are poorly effective in dealing with the exacerbations that account for hospitalization and asthma deaths. Commercially, there are pressures on these existing medicines too--a growing threat fr...
journal_title:Future medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-03-01 00:00:00
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更新日期:2018-05-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:2013-08-01 00:00:00
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