Abstract:
BACKGROUND:Irradiation therapy is an important pillar in the treatment of breast cancer. However, it can trigger capsular fibrosis, the most significant complication of implant-based breast reconstruction. As collagen is the main component of fibrotic capsules, the collagenase of the bacterium Clostridium histolyticum poses a potential treatment option for this pathological condition. METHODS:Thirty-six rats received miniature silicone implants on their backs. On day 1, the implant sites of two groups were irradiated with 10 Gy. On day 120, one irradiated group received collagenase injections into the implant pockets (n = 12). Non-irradiated (n = 12) and irradiated capsules (n = 12) were injected with plain solvent solution serving as controls. Data were analyzed by means of in vivo imaging, histology, immunohistochemistry and gene expression analysis. RESULTS:Compared with both controls, the injection of collagenase led to significantly thinner capsules. This was verified by in vivo imaging and histology. Although irradiation provoked alterations in capsule collagen structure and vessel wall thickness, the application of collagenase resulted in a significant reduction of collagen density. This was accompanied by an up-regulation of VEGF-A gene expression. Of note, hematoma formation inside the implant pocket occurred in two cases after collagenase injection. CONCLUSIONS:The collagenase of the bacterium Clostridium histolyticum is effective in degrading irradiation-induced capsular fibrosis around silicone implants. Hematoma formation occurred most likely because of irradiation-induced alterations in vessel wall architecture and capsule vascularization. Further studies need to be performed to address the clinical safety of this novel treatment option.
journal_name
Aesthetic Plast Surgjournal_title
Aesthetic plastic surgeryauthors
Diehm YF,Hirche C,Berger MR,Heil J,Golatta M,Kotsougiani D,Pomahac B,Kneser U,Fischer Sdoi
10.1007/s00266-018-1267-ysubject
Has Abstractpub_date
2019-06-01 00:00:00pages
836-844issue
3eissn
0364-216Xissn
1432-5241pii
10.1007/s00266-018-1267-yjournal_volume
43pub_type
杂志文章abstract::Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . ...
journal_title:Aesthetic plastic surgery
pub_type: 信件
doi:10.1007/s00266-020-01754-7
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:In Western countries, dorsal hump reduction surgery is prevalent due to the nasal profiles of the patients admitted for esthetic rhinoplasty operations. There are numerous techniques for hump reduction. Currently, dorsal hump reduction techniques that allow the dorsum to be preserved are highly popular. OBJ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-020-01801-3
更新日期:2020-10-01 00:00:00
abstract::The aging female with excess arm fat and poor skin tone frequently refuses a brachioplasty scar due to permanent detectability. Traditional deep liposuction localized to the posterolateral aspect of the arm frequently leaves sagging, wrinkled skin. Circumferential para-Axillary Superficial Tumescent (CAST) liposuction...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s002669900144
更新日期:1997-11-01 00:00:00
abstract::Soft tissue filler injections are the second most common non-surgical procedure performed by the plastic surgeon. Embolization of intravascular material after facial injection is a rare but terrifying outcome due to the high likelihood of long-term sequela such as blindness and cerebrovascular accident. The literature...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章,评审
doi:10.1007/s00266-016-0728-4
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Otoplasty is a century-old procedure that, through continued modifications, now has over two hundred different procedures described in the literature. In this article, we seek to describe the anatomy and principles of aesthetic otoplasty, as well as some of the key contributions to aesthetic otoplasty. This ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章,评审
doi:10.1007/s00266-019-01441-2
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The objective of this article was to assist cosmetic-plastic surgeons in selecting aesthetic cosmetic gynecologic-plastic surgical interventions. METHODS:Target methodological analyses of pertinent evidence-based scientific papers and anecdotal information linked to surgical techniques for cosmetic-plastic ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章,评审
doi:10.1007/s00266-012-0031-y
更新日期:2013-04-01 00:00:00
abstract::The surgical correction of one of the most frequent congenital malformations, inverted nipples, is analyzed here following a long series of cases, some of which, among the first, date back 17 years and more. The article describes the previous surgical methods and the reasons why they failed, as well as the principle, ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s002669910010
更新日期:2000-01-01 00:00:00
abstract::Use of a vascular pedicled temporoparietalis muscle flap resurfaced with a full-thickness skin graft from the opposite ear, instead of less-than-favorable skin coverage, is advocated to achieve more satisfactory aesthetic results in total ear reconstruction handicapped by the presence of scarred local skin. The techni...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF01570713
更新日期:1984-01-01 00:00:00
abstract::A total of 165 patients with varying indications have been treated with Zyderm Collagen Implant. Among these patients, only 4 allergic reactions were found: 3 local and 1 general. Results obtained depend on the type of lesion treated; it is suggested that the treatment of rhytids provides the best indication for colla...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF01570348
更新日期:1985-01-01 00:00:00
abstract::Although rare, pyoderma gangrenosum (PG) occurs as one of the worst local complications following plastic surgery to the breast. The early manifestations are similar to a necrotizing wound infection, so diagnosis and correct management are often delayed. Failure of response to the aggressive treatment strategies neede...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-003-3017-y
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:The recent rise in popularity of minimally invasive facial aesthetic procedures has resulted in the overall heightened patient interest in lip rejuvenation. There is a variety of techniques and modifications for surgical upper lip enhancement described in the literature but no single method is considered opt...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-020-01871-3
更新日期:2020-07-16 00:00:00
abstract::Many women have a dwindled ptotic breast. The surgical solution for these two concurring problems has two separate procedures: augmentation and mastopexy. Combining these two procedure into one surgery is considered unpredictable and avoided by many physicians. This study presents a revised mastopexy-augmentation tech...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-011-9736-6
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Graft use is inevitable in some primary and secondary rhinoplasty cases with cartilage or bone deficiency. Although rib graft is one of the best graft sources, it has several disadvantages. The purpose of this study is to minimize the risks of using rib grafts. MATERIAL AND METHODS:Between 2018 and 2020, a ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-020-02108-z
更新日期:2021-01-11 00:00:00
abstract:BACKGROUND:This study was conducted to compare the effect of photobiomodulation therapy (low-level laser therapy) on ecchymosis after rhinoplasty. SUBJECTS AND METHODS:Sixty rhinoplasty candidates were randomly divided into two groups. Photobiomodulation, including red light (660 nm), infrared light (840 nm), and infr...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00266-020-01760-9
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The question of whether expander inflation/deflation status has any bearing on surgical complications in the setting of adjuvant radiation (XRT) has not been addressed. The objective of this study is to investigate whether the inflation/deflation status of the expander at the time of XRT is associated with c...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-017-0864-5
更新日期:2017-06-01 00:00:00
abstract::Skin redundancy of the upper eyelid is often associated with a variable degree of ptosis of the lateral third of the eyebrow, which increases the extent of the defect. Correcting this condition implies a combination of a temporal lift with a standard upper blepharoplasty. In the temporal lift it is possible to perform...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF00636269
更新日期:1993-07-01 00:00:00
abstract::The author describes the 45-year-old successful survival of a series of ivory implants, used by his father, Dr. Rafael Vilar-Sancho, to repair and reconstruct a severe nasal deformity. ...
journal_title:Aesthetic plastic surgery
pub_type: 传,历史文章,杂志文章
doi:10.1007/BF01575503
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Subcutaneous phosphatidylcholine to cause local lipolysis has been performed effectively and safely in the nonsurgical treatment of periorbital fat pads and also in the treatment of localized fat deposits in the abdomen, neck, arms and thighs. However, the studies do not explain the mechanism through which i...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-005-0170-5
更新日期:2006-07-01 00:00:00
abstract::A clinical study on the surgical anatomy of the upper-eyelid fat pads was performed on 55 consecutive patients who underwent a blepharoplasty. It was confirmed that the periorbital fat is encapsulated in compartments and that the number of fat pads varies. In 56% of the cases there were two fat pads and in the 44% thr...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF02273862
更新日期:1991-07-01 00:00:00
abstract::There have been many important analyses of prosthesis selection, techniques of implantation, and subpectoral or subglandular pockets, but only a few studies comparing and discussing the different approaches. The best incision must achieve a good and simple approach to the retromammary location, subpectoral or subgland...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s002669900314
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Breast hypertrophy can cause a variety of symptoms and affect lifestyle and quality of life. Breast reduction, being the most effective treatment, is sometimes difficult to establish as standard treatment in obese patients (difficulties to differentiate symptoms from macromastia or from obesity, higher rate ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-015-0601-x
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The authors report their experience with autologous graft rhinoplasties. METHODS:Data were collected retrospectively, with selection of only autologous grafts from 2,000 rhinoplasties performed at the Plastic and Reconstructive Department of the University of Rome Tor Vergata. RESULTS:A total of 62 patient...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-005-0184-z
更新日期:2006-03-01 00:00:00
abstract::Melkersson-Rosenthal syndrome is a rare condition which consists of progressive and recurrent orofacial edema, intermittent facial palsy, and lingua plicata. Labial swelling is the most common feature of this syndrome complex. The lips may enlarge up to three times their normal size, resulting in aesthetic deformity a...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s002669900173
更新日期:1998-03-01 00:00:00
abstract::Skeletal deformity in the fronto-orbital region resulting from various problems can have significant aesthetic concerns. Restoring an aesthetically acceptable appearance relies most importantly on the restoration of a precise skeletal contour. Current surgical options for depression deformities or partial-thickness de...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-011-9723-y
更新日期:2011-12-01 00:00:00
abstract:UNLABELLED:Traumatic tattoos can result from accidental deposition of foreign particles in the dermis. These pigmented particles become permanently lodged in the dermis after re-epithelialization of the wound and can give rise to irregular black or blue discoloration of the skin. Different methods for tattoo removal ex...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-014-0290-x
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Autologous lipotransfer is seen as an ideal filler for soft tissue reconstruction. The main limitation of this procedure is the unpredictable resorption and volume loss of the fat graft. In the recent decade, an increasing amount of research has focused on the use of adipose tissue-derived stromal cells (A...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章,评审
doi:10.1007/s00266-016-0613-1
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Since its introduction, augmentation mammaplasty has gained widespread popularity, as demonstrated by the fact that an estimated 2 million women in the United States have received implants. During recent decades, several surgical approaches have evolved in terms of implant placement or site of access to the ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-005-0095-z
更新日期:2005-11-01 00:00:00
abstract::The independent effect of the contraction of various facial mimetic muscles on the nasolabial fold was defined through study of cadaver dissections. The four major lip elevator muscles were identified and the effect of traction of these muscles on the nasolabial fold was studied. This study identified the levator alae...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF00450609
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Tissue expansion for breast reconstruction after mastectomy is a safe and effective procedure. A magnetic resonance imaging (MRI) scan can be requested for patients with a breast expander to evaluate concurrent diseases. The electromagnetic field of the MR can interfere with biomedical devices, resulting in ...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/s00266-012-9908-z
更新日期:2012-08-01 00:00:00
abstract::A survey from 1983 through 1988 of patients who underwent augmentation mammoplasty performed by the transaxillary subpectorial approach revealed the operation to be amazingly trouble-free, with patient satisfaction reaching 98.5%. The severe problem of capsular contracture seen in the 1978 prepectoral (submammary) cas...
journal_title:Aesthetic plastic surgery
pub_type: 杂志文章
doi:10.1007/BF02273844
更新日期:1991-04-01 00:00:00