Assessing Residual Bias in Estimating Influenza Vaccine Effectiveness: Comparison of High-dose Versus Standard-dose Vaccines.

Abstract:

BACKGROUND:Estimating influenza vaccine effectiveness using an unvaccinated comparison group may result in biased effect estimates. OBJECTIVES:To explore the reduction of confounding bias in an active comparison of high-dose versus standard-dose influenza vaccines, as compared with vaccinated versus unvaccinated comparisons. METHODS:Using Medicare data from the United States end-stage renal disease program (2009-2013), we compared the risk of all-cause mortality among recipients of high-dose vaccine (HDV) versus standard-dose vaccine (SDV), HDV versus no vaccine, and SDV versus no vaccine. To quantify confounding bias, analyses were restricted to the preinfluenza season, when the protective effect of vaccination should not yet be observed. We estimated the standardized mortality ratio-weighted cumulative incidence functions using Kaplan-Meier methods and calculated risk ratios (RRs) and risk differences between groups. RESULTS:Among 350,921 eligible patients contributing 825,642 unique patient preinfluenza seasons, 0.8% received HDV, 70.5% received SDV, and 28.7% remained unvaccinated. Comparisons with unvaccinated patients yielded spurious decreases in mortality risk during the preinfluenza period, for HDV versus none [RR, 0.60; 95% confidence interval (CI), 0.51-0.70)] and SDV versus none (RR, 0.72; 95% CI, 0.70-0.75). The effect estimate was attenuated in the HDV versus SDV comparison (RR, 0.89; 95% CI, 0.77-1.03). Estimates on the absolute scale followed a similar pattern. CONCLUSIONS:The HDV versus SDV comparison yielded less-biased estimates of the all-cause mortality before influenza season compared to those with nonuser comparison groups. Vaccine effectiveness and safety researchers should consider the active comparator design to reduce bias due to differences in underlying health status between vaccinated and unvaccinated individuals.

journal_name

Med Care

journal_title

Medical care

authors

Butler AM,Layton JB,Krueger WS,Kshirsagar AV,McGrath LJ

doi

10.1097/MLR.0000000000001018

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

73-78

issue

1

eissn

0025-7079

issn

1537-1948

journal_volume

57

pub_type

杂志文章
  • Use of patient-reported outcomes in randomized, double-blind, placebo-controlled clinical trials.

    abstract:BACKGROUND:To optimize the use of patient-reported outcomes (PROs) in clinical research, it is first necessary to review the current use of these outcomes in clinical trials to determine under what circumstances they are most useful, and to reveal current limitations. PURPOSE:To investigate current patterns of use of ...

    journal_title:Medical care

    pub_type: 杂志文章,评审

    doi:10.1097/MLR.0b013e3182064aa2

    authors: Dinan MA,Compton KL,Dhillon JK,Hammill BG,Dewitt EM,Weinfurt KP,Schulman KA

    更新日期:2011-04-01 00:00:00

  • Comparison of approaches for estimating incidence costs of care for colorectal cancer patients.

    abstract:BACKGROUND:Estimates of the costs of medical care vary across patient populations, data sources, and methods. The objective of this study was to compare 3 approaches for estimating the incidence costs of colorectal cancer (CRC) care using similar patient populations, but different data sources and methods. METHODS:We ...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0b013e3181a4f482

    authors: Yabroff KR,Warren JL,Schrag D,Mariotto A,Meekins A,Topor M,Brown ML

    更新日期:2009-07-01 00:00:00

  • A measurement model of the Medical Outcomes Study 36-Item Short-Form Health Survey in a clinical sample of disadvantaged, older, black, and white men and women.

    abstract::The authors assess the factorial validity of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) for use in a clinical sample of disadvantaged, older adults with significant comorbidities. Confirmatory factor analysis was performed using LISREL VIII on data obtained from baseline face-to-face interview...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-199606000-00004

    authors: Wolinsky FD,Stump TE

    更新日期:1996-06-01 00:00:00

  • Characterizing patient dysfunction in Alzheimer's-type dementia.

    abstract::Although Alzheimer's-type dementia (ATD) is characterized by global intellectual deterioration, few systematic efforts have been made to characterize overall dysfunction of ATD patients. The Sickness Impact Profile (SIP) was administered to ATD patients and family members to determine the concurrent validity of family...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-198805000-00002

    authors: Krenz C,Larson EB,Buchner DM,Canfield CG

    更新日期:1988-05-01 00:00:00

  • Validity of the AHRQ patient safety indicator for postoperative physiologic and metabolic derangement based on a national sample of medical records.

    abstract:OBJECTIVE:The Agency for Healthcare Research and Quality Patient Safety Indicator (PSI) 10, "Postoperative Physiologic and Metabolic Derangement" (PPMD), uses administrative data to detect postoperative acute kidney injury (AKI) requiring dialysis and diabetes-related complications. We sought to evaluate the indicator'...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0b013e31829c8b91

    authors: Zrelak PA,Romano PS,Tancredi DJ,Geppert JJ,Utter GH

    更新日期:2013-09-01 00:00:00

  • Medicaid Health Home Reducing Costs and Reliance on Emergency Department: Evidence From Iowa.

    abstract:BACKGROUND:The Affordable Care Act allowed an optional Medicaid State Plan benefit for states to establish Health Homes coordinating care for people who have chronic conditions. Differences in medical home program incentives and implementation styles are important to understand in evaluating effects on key outcomes suc...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000555

    authors: Shane DM,Nguyen-Hoang P,Bentler SE,Damiano PC,Momany ET

    更新日期:2016-08-01 00:00:00

  • Practice characteristics and performance of primary care practitioners.

    abstract:OBJECTIVES:The authors examined organizational characteristics of 16 primary care group practices to determine their influence on quality or quality improvement. METHODS:The authors used a data base compiled during a randomized, controlled trial of quality assurance interventions consisting of measures of guideline-re...

    journal_title:Medical care

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005650-199609002-00007

    authors: Hargraves JL,Palmer RH,Orav EJ,Wright EA

    更新日期:1996-09-01 00:00:00

  • Waiting for care. Queuing and resource allocation.

    abstract::Queues arise in medical care and serve as allocators in the absence of an effective market and when resources become perceptibly constrained. This is essentially the case in all countries where money is not the means for gaining access to medical services. A study estimated that the total wait in England was 96 days f...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-198702000-00006

    authors: Bloom BS,Fendrick AM

    更新日期:1987-02-01 00:00:00

  • Predictors of aggressive therapy for nonmetastatic prostate carcinoma in Massachusetts from 1998 to 2002.

    abstract:BACKGROUND:Most studies have found that black men are less likely to receive aggressive therapy for nonmetastatic prostate cancer, even after controlling for covariates. However, previous studies have not accounted for the clustering of outcomes by facility. OBJECTIVE:We sought to compare the proportions of black and ...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/01.mlr.0000257144.29928.f0

    authors: Rose AJ,Backus BM,Gershman ST,Santos P,Ash AS,Battaglia TA

    更新日期:2007-05-01 00:00:00

  • Format review: evaluating implementation of the problem-oriented medical record.

    abstract::As interest in the problem-oriented medical record (POMR) develops, and more medical settings begin to implement the system, many observers are expressing a desire to know how well the system is being used and accepted. Moreover, settings currently using the POMR system have a need to document the effectiveness of the...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-197610000-00006

    authors: Hammett WH,Sandlow LJ,Bashook PG

    更新日期:1976-10-01 00:00:00

  • Demographic differences in health preferences in the United States.

    abstract:BACKGROUND:The United States has a culturally and demographically diverse populace, and the aim of this study was to examine differences in health preferences by sex, age, ethnicity, and race. METHODS:We assessed preferences for health outcomes defined by the PROMIS-29 survey in a sample of the US population. On the b...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000066

    authors: Craig BM,Reeve BB,Cella D,Hays RD,Pickard AS,Revicki DA

    更新日期:2014-04-01 00:00:00

  • Measuring the quality of care provided to community dwelling vulnerable elders dually enrolled in Medicare and Medicaid.

    abstract:CONTEXT:Small studies suggest that the quality of healthcare provided to older patients needs improvement. However, measuring the quality of care for larger groups of older adults is difficult. OBJECTIVE:To measure the quality of care in a community-dwelling vulnerable geriatric population using administrative data to...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0b013e318127143e

    authors: Zingmond DS,Wilber KH,Maclean CH,Wenger NS

    更新日期:2007-10-01 00:00:00

  • An examination of longitudinal CAUTI, SSI, and CDI rates from key HHS data systems.

    abstract:BACKGROUND:In response to the growing concern about healthcare-associated infections (HAIs), US Department of Health and Human Services (HHS) developed the National Action Plan to Prevent Healthcare-associated Infections. A key focus of the Action Plan is the setting of HAI metrics and targets and the enhancement and d...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000027

    authors: Weinberg DA,Kahn KL

    更新日期:2014-02-01 00:00:00

  • Spiritual care at the end of life in long-term care.

    abstract:BACKGROUND:There is growing attention given to the spiritual needs of dying patients and long-term care (LTC) facilities are common settings in which patients receive care as they approach death. OBJECTIVES:To describe the sources of support, the structure and processes of spiritual care in LTC, and examine the relati...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0b013e3181468b5d

    authors: Daaleman TP,Williams CS,Hamilton VL,Zimmerman S

    更新日期:2008-01-01 00:00:00

  • An introduction to multiple time series analysis.

    abstract::An expository account of multiple time series analysis is presented. Modeling several related time series together makes it possible to ascertain dynamic leading, lagging, and feedback relationships among the series; to produce more efficient forecasts and, in some situations; to develop control schemes. Procedures fo...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:

    authors: Tiao GC

    更新日期:1993-05-01 00:00:00

  • Organizational Influences on Time Pressure Stressors and Potential Patient Consequences in Primary Care.

    abstract:BACKGROUND:Primary care teams face daily time pressures both during patient encounters and outside of appointments. OBJECTIVES:We theorize 2 types of time pressure, and test hypotheses about organizational determinants and patient consequences of time pressure. RESEARCH DESIGN:Cross-sectional, observational analysis ...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000974

    authors: McDonald KM,Rodriguez HP,Shortell SM

    更新日期:2018-10-01 00:00:00

  • Does Offering Battlefield Acupuncture Lead to Subsequent Use of Traditional Acupuncture?

    abstract:OBJECTIVES:Veterans Health Administration encourages auricular acupuncture (Battlefield Acupuncture/BFA) as a nonpharmacologic approach to pain management. Qualitative reports highlighted a "gateway hypothesis": providing BFA can lead to additional nonpharmacologic treatments. This analysis examines subsequent use of t...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000001367

    authors: Thomas ER,Zeliadt SB,Coggeshall S,Gelman H,Resnick A,Giannitrapani K,Olson J,Kligler B,Taylor SL

    更新日期:2020-09-01 00:00:00

  • Would eliminating differences in physician practice style reduce geographic variations in cataract surgery rates?

    abstract::This study uses Medicare physician-claims data to examine patient and physician contributions to variations in cataract surgery rates across U.S. metropolitan areas. Utilization is modelled as having two phases: the decision to seek an ophthalmologist's care, which is made by patients, and the decision to perform surg...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-199312000-00004

    authors: Escarce JJ

    更新日期:1993-12-01 00:00:00

  • Extended use of indwelling urinary catheters in postoperative hip fracture patients.

    abstract:BACKGROUND:Indwelling urinary catheters are used postoperatively in hip fracture care. Their use beyond the immediate postoperative period may result in excess nosocomial infections. OBJECTIVES:The objectives of this study were to explore the relationship between extended indwelling urinary catheterization and outcome...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/01.mlr.0000178199.07789.32

    authors: Wald H,Epstein A,Kramer A

    更新日期:2005-10-01 00:00:00

  • The lifetime cost of current human immunodeficiency virus care in the United States.

    abstract:OBJECTIVE:We sought to project the lifetime cost of medical care for human immunodefiency virus (HIV)-infected adults using current antiretroviral therapy (ART) standards. METHODS:Medical visits and hospitalizations for any reason were from the HIV Research Network, a consortium of high-volume HIV primary care sites. ...

    journal_title:Medical care

    pub_type: 杂志文章,评审

    doi:10.1097/01.mlr.0000228021.89490.2a

    authors: Schackman BR,Gebo KA,Walensky RP,Losina E,Muccio T,Sax PE,Weinstein MC,Seage GR 3rd,Moore RD,Freedberg KA

    更新日期:2006-11-01 00:00:00

  • The Pediatric Economic Database Evaluation (PEDE) Project: establishing a database to study trends in pediatric economic evaluation.

    abstract:BACKGROUND:While standard methods for conducting economic evaluations have evolved, little attention has been paid to the conduct of these studies in special populations such as children. OBJECTIVES:To build a database of pediatric economic evaluations and to examine trends in publication characteristics over a 20-yea...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/01.MLR.0000088451.56688.65

    authors: Ungar WJ,Santos MT

    更新日期:2003-10-01 00:00:00

  • Measuring the job satisfaction of physicians in organized settings.

    abstract::The accurate measurement of physician job satisfaction in organized practice settings is important for both policy and administrative purposes. Previous efforts to measure physician job satisfaction have been unsatisfactory because of either conceptual or methodologic weaknesses. New measures of physician job satisfac...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-198401000-00005

    authors: Lichtenstein R

    更新日期:1984-01-01 00:00:00

  • The measurement of expenditures for outpatient physician and dental services: methodological findings from the health insurance study.

    abstract::Survey data measuring outpatient health expenditure are evaluated for item nonresponse, measurement error, and bias. Item nonresponse is high for persons whose health care is financed through the public sector, but is otherwise manageable. Estimates of mean total and out-of-pocket physician and dental expenditure from...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-197611000-00002

    authors: Marquis KH,Marquis MS,Newhouse JP

    更新日期:1976-11-01 00:00:00

  • A Detailed Exploration Into the Association of Prescribed Opioid Dosage and Overdose Deaths Among Patients With Chronic Pain.

    abstract:BACKGROUND:High opioid dosage has been associated with overdose, and clinical guidelines have cautioned against escalating dosages above 100 morphine-equivalent mg (MEM) based on the potential harm and the absence of evidence of benefit from high dosages. However, this 100 MEM threshold was chosen somewhat arbitrarily....

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000505

    authors: Bohnert AS,Logan JE,Ganoczy D,Dowell D

    更新日期:2016-05-01 00:00:00

  • An examination of the Resource-Based Relative Value Scale cross-specialty linkage method.

    abstract::The Resource-Based Relative Value Scale (RBRVS) was developed by surveying panels of physicians from single specialties, then merging the specialty-specific results into a common work scale. The merging process involved two steps: 1) specification of links or equivalent services across specialties: and 2) use of links...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-199401000-00003

    authors: Morton SC,Kominski GF,Kahan JP

    更新日期:1994-01-01 00:00:00

  • The urban health care clinic and its substance abuse population.

    abstract::The effect of large numbers of patients with a history of substance abuse upon a health care system is rarely considered, nor is the health care system's response to such a clientele ever assessed. In this preliminary study, the collective effect of large numbers of substance abuse patients upon a clinic serving the u...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-199110000-00006

    authors: Cahill DF,Hodgkins BJ

    更新日期:1991-10-01 00:00:00

  • Language barriers, location of care, and delays in follow-up of abnormal mammograms.

    abstract:BACKGROUND:Breast cancer is frequently diagnosed after an abnormal mammography result. Language barriers can complicate communication of those results. OBJECTIVES:We evaluated the association of non-English language with delay in follow-up. METHODS:Retrospective cohort study of women at 3 mammography facilities parti...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0b013e31822dcf2d

    authors: Karliner LS,Ma L,Hofmann M,Kerlikowske K

    更新日期:2012-02-01 00:00:00

  • Tonsillectomies, adenoidectomies, audits: have surgical indications been met?

    abstract::In the Seattle Prepaid Health Care Project, we studied medical records and claims information for all 97 children undergoing tonsillectomy and/or adenoidectomy in an independent practice plan from February 1971, through January 1975. Overall only 32 per cent of the procedures met commonly promulgated indications of su...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-197811000-00005

    authors: LoGerfo JP,Dynes IM,Frost F,Diehr PK,Richardson WC

    更新日期:1978-11-01 00:00:00

  • Barriers to Care and Health Care Utilization Among the Publicly Insured.

    abstract:BACKGROUND:Although the Affordable Care Act has been successful in expanding Medicaid to >17 million people, insurance alone may not translate into access to health care. Even among the insured, substantial barriers to accessing services inhibit health care utilization. OBJECTIVES:We examined the effect of selected ba...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/MLR.0000000000000644

    authors: Allen EM,Call KT,Beebe TJ,McAlpine DD,Johnson PJ

    更新日期:2017-03-01 00:00:00

  • Segmentation in local hospital markets.

    abstract::This study examines evidence of market segmentation on the basis of patients' insurance status, demographic characteristics, and medical condition in selected local markets in California in the years 1983 and 1989. Substantial differences exist in the probability patients may be admitted to particular hospitals based ...

    journal_title:Medical care

    pub_type: 杂志文章

    doi:10.1097/00005650-199301000-00004

    authors: Dranove D,White WD,Wu L

    更新日期:1993-01-01 00:00:00