Abstract:
OBJECTIVE:We sought to project the lifetime cost of medical care for human immunodefiency virus (HIV)-infected adults using current antiretroviral therapy (ART) standards. METHODS:Medical visits and hospitalizations for any reason were from the HIV Research Network, a consortium of high-volume HIV primary care sites. HIV treatment drug regimen efficacies were from clinical guidelines and published sources; data on other drugs used were not available. In a computer simulation model, we projected HIV medical care costs in 2004 U.S. dollars. RESULTS:From the time of entering HIV care, per person projected life expectancy is 24.2 years, discounted lifetime cost is Dollars 385,200, and undiscounted cost is Dollars 618,900 for adults who initiate ART with CD4 cell count < 350/microL. Seventy-three percent of the cost is antiretroviral medications, 13% inpatient care, 9% outpatient care, and 5% other HIV-related medications and laboratory costs. For patients who initiate ART with CD4 cell count < 200/microL, projected life expectancy is 22.5 years, discounted lifetime cost is Dollars 354,100 and undiscounted cost is Dollars 567,000. Results are sensitive to drug manufacturers' discounts, ART efficacy, and use of enfuvirtide for salvage. If costs are discounted to the time of infection, the discounted lifetime cost is Dollars 303,100. CONCLUSIONS:Effective ART regimens have substantially improved survival and have increased the lifetime cost of HIV-related medical care in the U.S.
journal_name
Med Carejournal_title
Medical careauthors
Schackman BR,Gebo KA,Walensky RP,Losina E,Muccio T,Sax PE,Weinstein MC,Seage GR 3rd,Moore RD,Freedberg KAdoi
10.1097/01.mlr.0000228021.89490.2asubject
Has Abstractpub_date
2006-11-01 00:00:00pages
990-7issue
11eissn
0025-7079issn
1537-1948pii
00005650-200611000-00005journal_volume
44pub_type
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