A meta-analysis of safety and efficacy of regorafenib for refractory metastatic colorectal cancer.


BACKGROUND:Patients with metastatic colorectal cancer (mCRC) often suffer from progressive disease despite previous therapy. It has been a great challenge for those patients. In 2012, regorafenib was approved for mCRC. In this meta-analysis, we aimed to collect and present existing data to explorethe clinical use of regorafenib. METHODS:The online electronic databases, such as PubMed, Embase, and the Cochrane library, updated to November 2017 were systematically searched. Trials on the effectiveness of regorafenib in patients who suffer from treatment-refractory metastatic colorectal cancer were included, of which the main outcomes included 3 parameters: overall survival (OS), progression-free survival (PFS), and grade 3/4 AE. RESULTS:Totally, 4 trials were included in this meta-analysis. The OD was significantly better with the use of regorafenib (OR = 0.78, 95%CI = 0.65-0.94, I = 69%, P = .008), and PFS (OR = 0.52, 95%CI = 0.34-0.79, I = 97%, P = .002). However, the most common toxicities occurred more frequently in the regorafenib group than the control group (OR = 3.73, 95%CI = 1.68-8.28, I = 79%, P = .001). CONCLUSION:Regorafenib demonstrates better efficacy and has manageable adverse-event profile for treatment-refractory mCRC. Considering the safety feature of regorafenib, further studies and clinical trials are warranted to investigate the dosing of regorafenib and alternative approaches are needed to explore predictive biomarker fortherapy selection.


Medicine (Baltimore)




Xue WS,Men SY,Liu W,Liu RH




Has Abstract


2018-10-01 00:00:00
















  • Inflammatory cytokine depletion in severe coronavirus disease 2019 infectious pneumonia: A case report.

    abstract:RATIONALE:Multiorgan/system injury was observed in severely infected coronavirus disease 2019 (COVID-19) patients, in addition to viral pneumonia. Recognizing and correcting the key and immediate dysfunctions may reduce mortality. PATIENT CONCERNS:A 66-year-old previously healthy male patient was referred to the isola...


    pub_type: 杂志文章


    authors: Yang B,Yang J,Zhou L,Xue C,Li H,Hu W,Liu N

    更新日期:2020-12-04 00:00:00

  • Modified 2-port laparoscopic herniorrhaphy with Kirschner wire in children: A retrospective review.

    abstract:BACKGROUND:Pediatric inguinal hernia is one of the most common diseases in children, and laparoscopy is the main surgical method. This study aims to evaluate the efficacy of a new modified 2-port laparoscopic herniorrhaphy with Kirschner wire (TLHK) for inguinal hernia in children. METHODS:A total of 5304 children wit...


    pub_type: 杂志文章


    authors: Cao Z,Chen J,Li Z,Li G

    更新日期:2018-10-01 00:00:00

  • Prescription fill rates for acute and chronic medications in claims-EMR linked data.

    abstract::Nonadherence to prescribed medications poses a significant public health problem. Prescription data in electronic medical records (EMRs) linked with pharmacy claims data provides an opportunity to examine the prescription fill rates and factors associated with it.Using a claims-EMR linked data, patients who had a pres...


    pub_type: 杂志文章


    authors: Park Y,Yang H,Das AK,Yuen-Reed G

    更新日期:2018-11-01 00:00:00

  • Patterns of lymph node metastasis in locally advanced cervical cancer.

    abstract::The aim of this study was to investigate patterns and locations of lymph node metastasis in locally advanced cervical cancers.A total of 244 consecutive patients with stage IIb cervical cancer were retrospectively evaluated. Contrast-enhanced CT scans were used for lymph node grading. Lymph nodes with the shortest axi...


    pub_type: 杂志文章


    authors: Liu Z,Hu K,Liu A,Shen J,Hou X,Lian X,Sun S,Yan J,Zhang F

    更新日期:2016-09-01 00:00:00

  • Sclerosing thymoma: A rare case report and brief review of literature.

    abstract:RATIONALE:Sclerosing thymoma is an extremely rare mediastinal neoplasm; it was recognized for the first time in 1994 and to date only 15 cases have been reported. PATIENT CONCERNS:The present study report a case of a 65-year-old man who was incidentally found to have an anterior mediastinal nodule, without clinical sy...


    pub_type: 杂志文章


    authors: Li X,Wang M,Sun D

    更新日期:2018-04-01 00:00:00

  • Does adding variceal status to the Child-Turcotte-Pugh score improve its performance in predicting mortality in cirrhosis?

    abstract::The Child-Turcotte-Pugh (CTP) score is widely used worldwide to predict outcomes across a broad spectrum of liver diseases, mainly cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in cirrhotic patients, although the variceal status is not incorporated into the classic...


    pub_type: 杂志文章


    authors: Fan X,Wen M,Shen Y,Wang W,Yang X,Yang L

    更新日期:2016-09-01 00:00:00

  • Not only for melanoma. Subcutaneous pseudoprogression in lung squamous-cell carcinoma treated with nivolumab: A case report.

    abstract:RATIONALE:Pseudoprogression, that is, initial tumor growth followed by subsequent tumor regression, has been well described for immunomodulation therapy in melanoma patients. This phenomenon is not well defined in lung cancer. Nivolumab, an anti-PD-1 monoclonal antibody, was recently approved for nonsmall cell lung can...


    pub_type: 杂志文章


    authors: Sarfaty M,Moore A,Dudnik E,Peled N

    更新日期:2017-01-01 00:00:00

  • Increased risk of appendectomy in patients with gastroesophageal reflux disease: A nested case-control study using a national sample cohort.

    abstract::The purpose of this study is to confirm and complement previous data regarding an association between gastroesophageal reflux disease and appendectomy.The Korean National Health Insurance Service-National Sample Cohort includes data from people ≥ 20 years old collected from 2002 to 2013. A total of 13,484 participants...


    pub_type: 杂志文章


    authors: Kim SY,Kim HJ,Lim H,Lim MS,Kim M,Choi HG

    更新日期:2018-12-01 00:00:00

  • The hepatic protective effects of tacrolimus as a rinse solution in liver transplantation: A meta-analysis.

    abstract:BACKGROUND:Tacrolimus was used as a rinse solution against ischaemia-reperfusion injury (IRI) in liver transplantation for years but its protective effects remain controversies. METHODS:We conducted literature retrieval in electronic databases including MEDLINE, EMBASE and Cochrane Central to identify relevant randomi...


    pub_type: 杂志文章,meta分析


    authors: Guo T,Lei J,Gao J,Li Z,Liu Z

    更新日期:2019-05-01 00:00:00

  • Should screening for colorectal neoplasm be recommended in patients at high risk for coronary heart disease: a cross-sectional study.

    abstract::Colorectal neoplasm (CRN) and coronary heart disease (CHD) share common risk factors. We aimed to assess the risk for CRN in patients who are at high risk for developing CHD determined by measurements, which are independent from the risk factors for CRN.This study was conducted on individuals who underwent total colon...


    pub_type: 杂志文章


    authors: Basyigit S,Ozkan S,Uzman M,Ertugrul DT,Kefeli A,Aktas B,Yeniova AO,Asilturk Z,Nazligul Y,Simsek H,Simsek G,Ayturk M,Yavuz B

    更新日期:2015-05-01 00:00:00

  • Comparison of psychiatric disturbances in patients with multiple sclerosis and neuromyelitis optica.

    abstract::Although both multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases, their psychiatric disturbances may differ given differences in the neurological manifestations. We used subjective and objective measurements to compare the psychiatric disturbances in patients with MS and NMO.Psychiatric ...


    pub_type: 杂志文章


    authors: Shin JS,Kwon YN,Choi Y,Lee JY,Lee YI,Hwang JH,Choi SH,Kim SM

    更新日期:2019-09-01 00:00:00

  • Pasteurella multocida infections. Report of 34 cases and review of the literature.

    abstract::Pasteurella multocida, a small, gram-negative coccobacillus , is part of the normal oral flora of many animals, including the dog and cat. P. multocida is the etiologic agent in a variety of infectious disease syndromes. We have reported 34 cases of infection caused by P. multocida and have reviewed the English litera...


    pub_type: 杂志文章,评审


    authors: Weber DJ,Wolfson JS,Swartz MN,Hooper DC

    更新日期:1984-05-01 00:00:00

  • Combined endoscopic submucosal dissection and transanal minimally invasive surgery for the management of lower rectal adenoma extending above the dentate line: A case report.

    abstract:RATIONALE:Minimally invasive surgery is used to treat early colorectal tumors. Endoscopic submucosal dissection (ESD) for resection of tumors extending above the dentate line (particularly those with concomitant hemorrhoids) is technically difficult. We present a case of a patient with a lower rectal adenoma extending ...


    pub_type: 杂志文章


    authors: Nepal P,Mori S,Kita Y,Tanabe K,Baba K,Sasaki F,Nasu Y,Ido A,Uchikado Y,Kurahara H,Arigami T,Sakoda M,Maemura K,Natsugoe S

    更新日期:2019-05-01 00:00:00

  • Factors associated with delayed diagnosis of infective endocarditis: A retrospective cohort study in a teaching hospital in Japan.

    abstract::Patients with infective endocarditis (IE), have high mortality and morbidity, however, its early diagnosis is difficult. Few studies have examined the delayed diagnosis of IE. We aimed to investigate the factors associated with the diagnostic delay of IE.A retrospective cohort study was conducted for consecutive patie...


    pub_type: 杂志文章


    authors: Nishiguchi S,Nishino K,Kitagawa I,Tokuda Y

    更新日期:2020-07-24 00:00:00

  • Characteristics of Small Intestinal Diseases on Single-Balloon Enteroscopy: A Single-Center Study Conducted Over 6 Years in China.

    abstract::The small intestine has been considered inaccessible for a long term. The development of single-balloon endoscopy has greatly improved the diagnosis and treatment possibilities for small intestinal diseases.In this study, we aimed to explore the demographic characteristics and small intestinal diseases of patients who...


    pub_type: 杂志文章


    authors: Tao Z,Liu GX,Cai L,Yu H,Min XJ,Gan HT,Yang K,Sq L,Yan J,Chen L,Tan QH,Wu JC,Huang XL

    更新日期:2015-10-01 00:00:00

  • Erratum: Case report of a Li-Fraumeni syndrome-like phenotype with a de novo mutation in CHEK2: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000004251.]. ...


    pub_type: 已发布勘误



    更新日期:2016-12-09 00:00:00

  • Different Risk of Common Gastrointestinal Disease Between Groups Undergoing Hemodialysis or Peritoneal Dialysis or With Non-End Stage Renal Disease: A Nationwide Population-Based Cohort Study.

    abstract::Peritoneal dialysis (PD) is one type of renal replacement therapy, but potential peritoneal damage and gastrointestinal (GI) tract adverse effects during long-term exposure to bio-incompatible dialysate remain a concern. Although GI disease frequently occurs in dialysis patients, whether the risk of GI diseases differ...


    pub_type: 杂志文章


    authors: Lee YC,Hung SY,Wang HH,Wang HK,Lin CW,Chang MY,Ho LC,Chen YT,Wu CF,Chen HC,Wang WM,Sung JM,Chiou YY,Lin SH

    更新日期:2015-09-01 00:00:00

  • Local resection of rectal neuroendocrine tumor with first clinical manifestation of giant liver metastasis by transanal endoscopic microsurgery: A case report.

    abstract:RATIONALE:Rectal neuroendocrine tumor (NET) is a relatively rare tumor. Well-differentiated NETs (G1 and G2) rarely display distant metastasis at initial diagnosis. Currently, treatment for the primary lesions of rectal NETs with liver metastasis remains controversial. The liver metastasis was resected in local hospita...


    pub_type: 杂志文章


    authors: Xu G,Wang P,Xiao Y,Wu X,Lin G

    更新日期:2017-12-01 00:00:00

  • Vestibulo-ocular reflex tests may reflect unilateral Ménière disease progression: A cross-sectional study.

    abstract:ABSTRACT:Vestibular disorders can manifest several patterns of horizontal vestibulo-ocular reflex (VOR) impairment, which can be detected by caloric test and video head impulse test (vHIT). Several studies have examined the patterns of caloric-vHIT response in Ménière disease (MD). The purpose of this study was to inve...


    pub_type: 杂志文章


    authors: Zhou R,Leng Y,Liu B

    更新日期:2020-12-24 00:00:00

  • Topical use of tranexamic acid can effectively decrease hidden blood loss during posterior lumbar spinal fusion surgery: A retrospective study.

    abstract::In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion su...


    pub_type: 杂志文章


    authors: Ren Z,Li S,Sheng L,Zhuang Q,Li Z,Xu D,Chen X,Jiang P,Zhang X

    更新日期:2017-10-01 00:00:00

  • Halomonas, a newly recognized human pathogen causing infections and contamination in a dialysis center: three new species.

    abstract::Our Renal Care Center (RCC) is a separate building, performing almost 2500 outpatient dialysis runs per month. In May 2007, 2 patients developed, days apart, bacteremia with an apparently identical nonfermentative Gram-negative rod. Because of difficulty identifying the organism, testing in the Biolog system identifie...


    pub_type: 杂志文章,评审


    authors: Stevens DA,Hamilton JR,Johnson N,Kim KK,Lee JS

    更新日期:2009-07-01 00:00:00

  • The Case for Adolescent HIV Vaccination in South Africa: A Cost-Effectiveness Analysis.

    abstract::Despite comprising 0.7% of the world population, South Africa is home to 18% of the global human immunodeficiency virus (HIV) prevalence. Unyielding HIV subepidemics among adolescents threaten national attempts to curtail the disease burden. Should an HIV vaccine become available, establishing its point of entry into ...


    pub_type: 杂志文章


    authors: Moodley N,Gray G,Bertram M

    更新日期:2016-01-01 00:00:00

  • Anti-angiogenesis treatment in a patient with appendix metastasis of small cell lung cancer: A case report.

    abstract:RATIONALE:Small-cell lung cancer (SCLC) is a common pathological type of lung cancer, but appendiceal metastasis of SCLC was rare. At present, clinical studies on the maintenance therapy of SCLC have not reached a significant conclusion. PATIENT CONCERNS:We reported on a 52-year-old man who diagnosed as extensive stag...


    pub_type: 杂志文章


    authors: Xue P,Wang N,Mao Y,Zhu S

    更新日期:2019-04-01 00:00:00

  • Risk factors for death in children with critical and severe hand-foot-and-mouth disease in Chongqing, China: An observational study.

    abstract::Hand-foot-and-mouth disease (HFMD) is a common childhood infection that may lead to serious complications and even death. Globally, epidemics of HFMD are increasing each year, especially in China. This study aimed to identify risk factors for death in children with critical and severe HFMD in Chongqing, China.We perfo...


    pub_type: 杂志文章


    authors: Zheng G,Cao J,Yu J,Zhang Z,Liu Q,Chen J

    更新日期:2017-12-01 00:00:00

  • Ten-Year Changes in the Hepatitis B Prevalence in the Birth Cohorts in Korea: Results From Nationally Representative Cross-Sectional Surveys.

    abstract::To compare the prevalence of hepatitis B virus (HBV) infection over a 10-year period in terms of population-level trends, we established hypothetical birth cohorts that represented each 10-year interval age group.We used data from the Korean National Health and Nutrition Examination Surveys conducted between 1998 to 2...


    pub_type: 杂志文章


    authors: Park B,Jung KW,Oh CM,Choi KS,Suh M,Jun JK

    更新日期:2015-10-01 00:00:00

  • The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population.

    abstract::Dyslipidemia is one of the most important factors for coronary artery disease (CAD). The atherogenic index of plasma (AIP), a new comprehensive lipid index, might be a strong marker for predicting the risk of CAD.A hospital-based case-control study including 2936 CAD patients and 2451 controls was conducted in a Chine...


    pub_type: 杂志文章


    authors: Cai G,Shi G,Xue S,Lu W

    更新日期:2017-09-01 00:00:00

  • Preoperative lymphocyte-to-monocyte ratio (LMR) could independently predict overall survival of resectable gastric cancer patients.

    abstract::Preoperational hemogram parameters have been reported to be associated with the prognosis of several types of cancers. This study aimed to investigate the prognostic value of hematological parameters in gastric cancer in a Chinese population. A total of 870 gastric cancer patients who underwent radical tumorectomy wer...


    pub_type: 杂志文章


    authors: Pan YC,Jia ZF,Cao DH,Wu YH,Jiang J,Wen SM,Zhao D,Zhang SL,Cao XY

    更新日期:2018-12-01 00:00:00

  • Application of optimized digital surgical guides in mandibular resection and reconstruction with vascularized fibula flaps: Two case reports.

    abstract:RATIONALE:Currently, digital surgical techniques have been widely used in the precise treatment of mandibular resection and reconstruction with fibula flaps. Utilizing these innovative techniques in surgical planning and hardware fabrication before surgery has shown to provide great help. However, it is difficult for e...


    pub_type: 杂志文章


    authors: Han L,Zhang X,Guo Z,Long J

    更新日期:2020-08-28 00:00:00

  • Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report.

    abstract:RATIONALE:Stiff-person syndrome (SPS) is an uncommon neurological disorder with autoimmune features. Here, we report a 60-year-old man with SPS associated with critical illness polyneuropathy (CIP). CIP was diagnosed during an episode of acute respiratory failure secondary to muscular rigidity and spasms, which has rar...


    pub_type: 杂志文章


    authors: Cai Q,Wu C,Xu W,Liang Y,Liao S

    更新日期:2020-12-11 00:00:00

  • Clinical outcome comparison of polymethylmethacrylate bone cement with and without mineralized collagen modification for osteoporotic vertebral compression fractures.

    abstract::A retrospective study of consecutive patients.The purpose of this study was to compare the clinical effect of biomimetic mineralized collagen (MC) modified polymethylmethacrylate (PMMA) bone cement and traditional PMMA bone cement for the treatment of osteoporotic vertebral compression fractures (OVCF).New fracture on...


    pub_type: 杂志文章


    authors: Wang X,Kou JM,Yue Y,Weng XS,Qiu ZY,Zhang XF

    更新日期:2018-09-01 00:00:00