Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress.


:Early stages of avascular necrosis of the femoral head (AVNFH) can be conservatively treated with hyperbaric oxygen therapy (HBOT). This study investigated how HBOT modulates inflammatory markers and reactive oxygen species (ROS) in patients with AVNFH. Twenty-three male patients were treated with two cycles of HBOT, 30 sessions each with a 30 days break between cycles. Each session consisted of 90 minutes of 100% inspired oxygen at 2.5 absolute atmospheres of pressure. Plasma levels of tumor necrosis factor alfa (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1β) and ROS production were measured before treatment (T0), after 15 and 30 HBOT sessions (T1 and T2), after the 30-day break (T3), and after 60 sessions (T4). Results showed a significant reduction in TNF-α and IL-6 plasma levels over time. This decrease in inflammatory markers mirrored observed reductions in bone marrow edema and reductions in patient self-reported pain.


Bosco G,Vezzani G,Mrakic Sposta S,Rizzato A,Enten G,Abou-Samra A,Malacrida S,Quartesan S,Vezzoli A,Camporesi E




Has Abstract


2018-12-01 00:00:00












  • alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.

    abstract::Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity. The IC(50) value of cyanidin-3-galactoside was 0.50 +/- 0.05 mM against intestinal sucrase. A low dose of cyanidin-3-galactoside showed a synergistic inhibition on intestinal alpha-glucosidase (maltase and su...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Adisakwattana S,Charoenlertkul P,Yibchok-Anun S

    更新日期:2009-02-01 00:00:00

  • The inhibition of Clostridium chauvoei (jakari strain) neuraminidase activity by methanolic extracts of the stem barks of Tamarindus indicus and Combretum fragrans.

    abstract::The inhibition of neuraminidase from Clostridium chauvoei (jakari strain) with partially purified methanolic extracts of some plants used in Ethnopharmacological practice was evaluated. Extracts of two medicinal plants, Tamarindus indicus and Combretum fragrans at 100-1000 microg/ml, both significantly reduced the act...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Useh NM,Nok AJ,Ambali SF,Esievo KA

    更新日期:2004-08-01 00:00:00

  • Phosphoprotein levels, MAPK activities and NFkappaB expression are affected by fisetin.

    abstract::Flavonoids, polyphenolic phytochemicals, are ubiquitous in plants and are commonly present in the human diet. They may exert diverse beneficial effects, including antioxidant and anticarcinogenic activities. The present study was designed to evaluate three biomolecules that play important roles in the apoptotic proces...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: de Sousa RR,Queiroz KC,Souza AC,Gurgueira SA,Augusto AC,Miranda MA,Peppelenbosch MP,Ferreira CV,Aoyama H

    更新日期:2007-08-01 00:00:00

  • Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

    abstract::Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotox...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章,评审


    authors: Kusuzaki K,Matsubara T,Murata H,Logozzi M,Iessi E,Di Raimo R,Carta F,Supuran CT,Fais S

    更新日期:2017-12-01 00:00:00

  • Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor.

    abstract::Fraxamoside, a macrocyclic secoiridoid glucoside featuring a hydroxytyrosol group, was recently identified as a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. However, this activity and its considerably higher value than its derivatives oleuropein, oleoside 1...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Vitale RM,Antenucci L,Gavagnin M,Raimo G,Amodeo P

    更新日期:2017-12-01 00:00:00

  • Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.

    abstract:UNLABELLED:Abstract In biological systems, the Keap1/Nrf2/antioxidant response element pathway determines the ability of mammalian cells to adapt and survive conditions of oxidative, electrophilic and inflammatory stress by regulating the production of cytoprotective enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1, EC ...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Ghorab MM,Higgins M,Alsaid MS,Arafa RK,Shahat AA,Dinkova-Kostova AT

    更新日期:2014-12-01 00:00:00

  • Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives.

    abstract::A series of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline, and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives was designed, synthesised, and evaluated in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani, a...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Guillon J,Cohen A,Boudot C,Valle A,Milano V,Das RN,Guédin A,Moreau S,Ronga L,Savrimoutou S,Demourgues M,Reviriego E,Rubio S,Ferriez S,Agnamey P,Pauc C,Moukha S,Dozolme P,Nascimento SD,Laumaillé P,Bouchut A,Azas

    更新日期:2020-12-01 00:00:00

  • Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3.

    abstract::Numerous studies have highlighted the implications of the glycogen synthase kinase 3 (GSK-3) in several processes associated with Alzheimer's disease (AD). Therefore, GSK-3 has become a crucial therapeutic target for the treatment of this neurodegenerative disorder. Hereby, we report the design and multistep synthesis...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Sciú ML,Sebastián-Pérez V,Martinez-Gonzalez L,Benitez R,Perez DI,Pérez C,Campillo NE,Martinez A,Moyano EL

    更新日期:2019-12-01 00:00:00

  • Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury: in vitro study of isolated rat heart model.

    abstract::Poly(ADP-ribose) polymerase (PARP)-1 inhibitor has been suggested to attenuate the ischemia-reperfusion injury. We investigated the protective effect of the cardioplegia with a PARP-1 inhibitor, 4-hydoxyquinazoline (4-HQ), against myocardial ischemia-reperfusion injury. Isolated rat hearts were perfused on a Langendor...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Yamazaki K,Tanaka S,Sakata R,Miwa S,Oriyanhan W,Takaba K,Minakata K,Marui A,Ikeda T,Toyokuni S,Komeda M,Ueda K

    更新日期:2013-02-01 00:00:00

  • New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.

    abstract::Nerve agents such as sarin, cyclosarin and tabun are organophosphorus substances able to inhibit the enzyme acetylcholinesterase (AChE; EC AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication with these agents. None of the known AChE reactivators is able to react...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Hrabinova M,Musilek K,Jun D,Kuca K

    更新日期:2006-10-01 00:00:00

  • Antiproliferative activity of Humulus lupulus extracts on human hepatoma (Hep3B), colon (HT-29) cancer cells and proteases, tyrosinase, β-lactamase enzyme inhibition studies.

    abstract::The aims of this study were to examine the antiproliferation of Humulus lupulus extracts on human hepatoma carcinoma (Hep3B) and human colon carcinoma (HT-29) cell lines along with enzyme inhibitory effects of the crude extracts. Potential cell cytotoxicity of six different H. lupulus extracts were assayed on various ...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Cömert Önder F,Ay M,Aydoğan Türkoğlu S,Tura Köçkar F,Çelik A

    更新日期:2016-01-01 00:00:00

  • In vitro effect of schistosomicidal drugs on hepatic arylsulfatase B from the schistosoma-infected mouse.

    abstract::Arylsulfatase B (ASB) hydrolyzes the desulfation of N-acetylgalactosamine-4-sulfate at the non-reducing terminal of glycosaminoglycans. This enzyme activity was found to be elevated in mice schistosomiasis. In the present study, the catalytic and immunological properties of purified ASB from the liver of Schistosoma-i...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Balbaa M,Bassiouny K

    更新日期:2006-02-01 00:00:00

  • Synthesis and biological activities of new hydrazide derivatives.

    abstract::The synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. The chemical structures of the compounds were elucidated by IR, (1)H-NMR, FAB(+)-MS spectral data. Their biological activity against various bacteria, fungi species, and Mycobacterium tuberculosis was investiga...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Ozdemir A,Turan-Zitouni G,Kaplancikli ZA,Tunali Y

    更新日期:2009-06-01 00:00:00

  • The protective effect of docosahexaenoic acid on the bilirubin neurotoxicity.

    abstract::Usually, all newborns demonstrate high serum unconjugated bilirubin (UCB) level. UCB may induce adverse effects in the central nervous system. We aimed to evaluate the cytotoxic effects of UCB and the protective effects of docosahexaenoic acid (DHA) on astrocyte cell cultures. The viability of astrocyte cells decrease...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Becerir C,Kılıç İ,Sahin Ö,Özdemir Ö,Tokgün O,Özdemir B,Akca H

    更新日期:2013-08-01 00:00:00

  • Antiproliferative effects of metal complexes of new isatin hydrazones against HCT116, MCF7 and HELA tumour cell lines.

    abstract::New hydrazone ligands (HL) derived from 5-substituted isatins and 1-(4-(2-methoxybenzyl)-6-arylpyridazin-3-yl)hydrazines and its complexes with Co(II) and Cu(II) were synthesized. The new hydrazones and their complexes were characterized by means of elemental, spectral analyses and magnetic studies. Primary cytotoxici...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Kandile NG,Mohamed MI,Ismaeel HM

    更新日期:2012-06-01 00:00:00

  • Inhibition by N'-nitrosonornicotine of the catalytic activity of glutamate dehydrogenase in alpha-ketoglutarate amination.

    abstract::The effect of N'-nitrosonornicotine (NNN), one of the tobacco-specific nitrosamines, on the catalytic activity of glutamate dehydrogenase (GLDH) in the alpha-ketoglutarate amination, using reduced nicotinamide adenine dinucleotide as coenzyme, was studied by a chronoamperometric method. The maximum reaction rate of th...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Mao YA,Zhong KJ,Wei WZ,Wei XL,Lu HB

    更新日期:2005-02-01 00:00:00

  • Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms.

    abstract::A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC They were obtained by reductive ring opening of the newly synthesized N-alkylated saccha...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: D'Ascenzio M,Guglielmi P,Carradori S,Secci D,Florio R,Mollica A,Ceruso M,Akdemir A,Sobolev AP,Supuran CT

    更新日期:2017-12-01 00:00:00

  • GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen.

    abstract::We investigated the antioxidant and enzyme inhibitory activities and chemical composition of the hydro-distilled essential oil (0.35% yield) from aerial parts of Thymus spathulifolius. Antioxidant capacity of the oil was assessed by different methods including free radical scavenging (DPPH and ABTS), reducing power (F...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Ceylan R,Zengin G,Uysal S,Ilhan V,Aktumsek A,Kandemir A,Anwar F

    更新日期:2016-12-01 00:00:00

  • Purification of bovine serum paraoxonase and its immobilization on Eupergit C 250 L by covalent attachment.

    abstract::Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that protects lipoproteins, both low-density lipoprotein (LDL) and HDL, against oxidation, and is considered as an antioxidative/anti-inflammatory component of HDL. In this study, PON1 was purified from bovine serum by ammonium sulfate prec...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Sayın M,Guler OO

    更新日期:2015-02-01 00:00:00

  • Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety.

    abstract::Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesised via hybriding the H3R pharmacophore (aliphatic amine with propyloxy chain) with the 1,2,4-triazol...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Song M,Yan R,Zhang Y,Guo D,Zhou N,Deng X

    更新日期:2020-12-01 00:00:00

  • Selective inhibition of acetylcholinesterase in the cerebellum and hippocampus of mice following an acute treatment with malathion.

    abstract::Adult male ICR mice were treated by intraperitoneal injection with 250 mg/kg of bodyweight of commercial malathion (a dose corresponding to 1/12 the LD50). After 6 h, acetylcholinesterase (AChE) activity in blood, liver, and six brain regions was determined. A statistically significant inhibition was observed in whole...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Banasik M,Stedeford T,Persad AS,Ueda K,Tanaka S,Muro-Cacho C,Harbison RD

    更新日期:2003-12-01 00:00:00

  • Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors.

    abstract::Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geographic distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil. Superoxide dismutase (SOD) belongs to the antioxidant pathway of the parasites an...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Brito CCB,Silva HVCD,Brondani DJ,Faria AR,Ximenes RM,Silva IMD,Albuquerque JFC,Castilho MS

    更新日期:2019-12-01 00:00:00

  • Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B.

    abstract::The inhibition of monoamine oxidase B (MAO-B) could be an effective approach for the treatment of various neurological disorders. In this study, a series of 1, 4-benzodioxan-substituted chalcone derivatives were designed, synthesised and evaluated for their inhibitory activity against human MAO-B (hMAO-B). The majorit...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Kong Z,Sun D,Jiang Y,Hu Y

    更新日期:2020-12-01 00:00:00

  • Antioxidant properties of benzylchroman derivatives from Caesalpinia sappan L. against oxidative stress evaluated in vitro.

    abstract::The antioxidant activity of extracts from Caesalpinia sappan L. (CSL) was studied in vitro by evaluating the total phenolics, measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) and on reactive nitrogen species (RNS), and measuring the inhibitory effect on Cu(2...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章,收录出版


    authors: Lee MJ,Lee HS,Kim H,Yi HS,Park SD,Moon HI,Park WH

    更新日期:2010-10-01 00:00:00

  • Cruzain inhibition by hydroxymethylnitrofurazone and nitrofurazone: investigation of a new target in Trypanosoma cruzi.

    abstract::Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. NFOH has higher activity and lower mutagenicity. The aim of this work was to assess whether NF and its derivative NFOH would also be inhibitors of cruzain, besides their trypanothione reductase inhibitory ac...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Trossini GH,Malvezzi A,T-do Amaral A,Rangel-Yagui CO,Izidoro MA,Cezari MH,Juliano L,Chin CM,Menezes CM,Ferreira EI

    更新日期:2010-02-01 00:00:00

  • Sulfonamides incorporating fluorine and 1,3,5-triazine moieties are effective inhibitors of three β-class carbonic anhydrases from Mycobacterium tuberculosis.

    abstract::A new series of fluorine containing 1,3,5-triazinyl sulfonamide derivatives obtained from cyanuric fluoride, sulfanilamide/4-aminoethylbenzenesulfonamide followed and incorporating also amin0, amino alcohol and amino acid moieties have been investigated as inhibitors of three β-carbonic anhydrases (CAs, EC fr...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Ceruso M,Vullo D,Scozzafava A,Supuran CT

    更新日期:2014-10-01 00:00:00

  • Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents.

    abstract::An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 a...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Kanagarajan V,Thanusu J,Gopalakrishnan M

    更新日期:2011-04-01 00:00:00

  • Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds.

    abstract::A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. The investigated compounds showed inhibition constants in the range of 0.068-4003, 0.012-9.9 and 0...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Durdagi S,Korkmaz N,Işık S,Vullo D,Astley D,Ekinci D,Salmas RE,Senturk M,Supuran CT

    更新日期:2016-12-01 00:00:00

  • Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis.

    abstract::We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world's leading sexually transmitted infections, trichomoniasis. CAs are ubiquitous metalloenzymes belonging to eight evolutionarily divergent grou...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Urbański LJ,Di Fiore A,Azizi L,Hytönen VP,Kuuslahti M,Buonanno M,Monti SM,Angeli A,Zolfaghari Emameh R,Supuran CT,De Simone G,Parkkila S

    更新日期:2020-12-01 00:00:00

  • Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation.

    abstract::A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the ...

    journal_title:Journal of enzyme inhibition and medicinal chemistry

    pub_type: 杂志文章


    authors: Saxena N,Singh NT,Mishra M,Keshava GB,Shukla PK,Tripathi RP

    更新日期:2008-08-01 00:00:00