Modeling Pediatric Epilepsy Through iPSC-Based Technologies.

abstract：:Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T. Clin Neurophysiol. 2018;129:1660-1668. https://doi.org/10.1016/j.clinph.2...

journal_title：Epilepsy currents

authors： Husain AM

更新日期：2019-01-01 00:00:00

abstract：:Regarding efficacy of new antiepileptic drugs (AEDs) for seizure control, there are three important clinical questions. How effective are new AEDs when corrected for the efficacy of placebo? And even more important: How do new AEDs fare in terms of seizure remission compared with established agents? And finally: Have ...

journal_title：Epilepsy currents

authors： Schmidt D

更新日期：2011-01-01 00:00:00

abstract：:Advances in positron emission tomography (PET) techniques have allowed the measurement and imaging of neurotransmitter synthesis, transport, and receptor binding to be performed in vivo. With regard to epileptic disorders, imaging of neurotransmitter systems not only assists in the identification of epileptic foci for...

journal_title：Epilepsy currents

authors： Chugani HT,Chugani DC

更新日期：2005-11-01 00:00:00

abstract：:Brain malformations are now widely recognized in many forms of epilepsy. To investigate how malformed brain regions participate in the generation of seizure activity researchers have focused on animal models. Here we describe recent advances in this field. ...

journal_title：Epilepsy currents

authors： Baraban SC

更新日期：2001-09-01 00:00:00

abstract：:Advances in epilepsy treatment are occurring at a rapid pace, and it is challenging for us to keep up with the latest in our field. As we struggle to keep up with the literature and concentrate on our own research and clinical work, we often fail to exercise our imagination and envision what our field will be like in ...

journal_title：Epilepsy currents

authors： Privitera M

更新日期：2017-07-01 00:00:00

abstract：:Current theories on drug resistance in epilepsy include the drug transporter hypothesis, the drug target hypothesis, and a novel approach called the inherent severity model of epilepsy, which posits that the severity of the disease determines its relative response to medication. Valuable as each of these hypotheses is...

journal_title：Epilepsy currents

authors： Schmidt D,Löscher W

更新日期：2009-03-01 00:00:00

abstract：:Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897. BACKGROUND:Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safe...

journal_title：Epilepsy currents

authors： Perry MS

更新日期：2019-03-01 00:00:00

abstract：:Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian sp...

journal_title：Epilepsy currents

authors： Jobst BC,Gonzalez-Martinez J,Isnard J,Kahane P,Lacuey N,Lahtoo SD,Nguyen DK,Wu C,Lado F

更新日期：2019-01-01 00:00:00

abstract：:In 2008, the Food and Drug Administration (FDA) issued a warning that any and all antiepileptic drugs (AEDs) might increase the risk of suicidal ideation, suicide attempt, and completed suicide. Considerable confusion and concern followed regarding the use of these drugs, in general, and specifically for people with e...

journal_title：Epilepsy currents

authors： Hesdorffer DC,Berg AT,Kanner AM

更新日期：2010-11-01 00:00:00

abstract：:As the ketogenic diet approaches 100 years of continuous use, we reflect on its successes and consider new avenues of research for the next century. One controversial question is regarding whether ketogenic dietary therapies could be successful first-line treatments for epilepsy. Second, is it possible to mimic the me...

journal_title：Epilepsy currents

authors： Kossoff E,Cervenka M

更新日期：2020-05-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Velisek L

更新日期：2020-01-01 00:00:00

abstract：:Depression is the most frequent psychiatric comorbidity in patients with epilepsy. By the same token, patients with depression are at higher risk of developing epilepsy than are controls. Such bidirectional relations raise the question of whether both disorders share common pathogenic mechanisms, presenting with commo...

journal_title：Epilepsy currents

authors： Kanner AM

更新日期：2005-01-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Subramanian D,Santhakumar V

更新日期：2019-09-01 00:00:00

abstract：:Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome Ritter-Makinson S, Clemente-Perez A, Higashikubo B, Cho FS, Holden SS, Bennett E, Chkhaidze A, Eelkman Rooda OHJ, Cornet MC, Hoebeek FE, Yamakawa K, Cilio MR, Delord B, Paz JT. Cell Rep. 2019;26(1):54-64.e6. doi:10.1016/j.celrep.2018.12.018. L...

journal_title：Epilepsy currents

authors： Isom LL

更新日期：2019-05-01 00:00:00

abstract：:There has been considerable interest in using bumetanide, a diuretic chloride importer NKCC1 antagonist, to reduce intracellular chloride ([Cl(-)](i)) in epileptic neurons, thereby shifting the polarity of GABA from excitatory to inhibitory and ameliorating the actions of GABA-acting antiepileptic drugs. However, a re...

journal_title：Epilepsy currents

authors： Ben-Ari Y,Tyzio R

更新日期：2011-11-01 00:00:00

abstract：:Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, the roles played by interictal events in seizure occurrence and in epileptogenesis remain elusive. While interictal spikes may herald the onset of electrographic seizures, experimental data indicate that hippocampus-driven intericta...

journal_title：Epilepsy currents

authors： Avoli M,Biagini G,de Curtis M

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Established tonic-clonic status epilepticus (SE) does not stop in one-third of patients when treated with an intravenous (IV) benzodiazepine bolus followed by a loading dose of a second antiseizure medication (ASM). These patients have refractory status epilepticus (RSE) and a high risk of morbidity and death. ...

journal_title：Epilepsy currents

authors： Vossler DG,Bainbridge JL,Boggs JG,Novotny EJ,Loddenkemper T,Faught E,Amengual-Gual M,Fischer SN,Gloss DS,Olson DM,Towne AR,Naritoku D,Welty TE

更新日期：2020-09-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Ewell LA

更新日期：2020-01-01 00:00:00

abstract：:It has been known for some time that brain-derived neurotrophic factor (BDNF) is critical to normal development of the CNS, and more recently, studies also have documented the ability of BDNF to modify adult CNS structure and function. Therefore, it is no surprise that BDNF has been linked to diseases, such as epileps...

journal_title：Epilepsy currents

authors： Scharfman HE

更新日期：2005-05-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Bermeo-Ovalle A

更新日期：2020-01-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Gallagher M

更新日期：2020-01-01 00:00:00

abstract：:A large body of evidence that has accumulated over the past decade strongly supports the role of both blood-brain barrier (BBB) dysfunction and perivascular inflammation in the pathophysiology of epilepsy. Recent preclinical studies indicate that prolonged seizure- or brain injury-induced BBB dysfunction and subsequen...

journal_title：Epilepsy currents

authors： Gorter JA,Aronica E,van Vliet EA

更新日期：2019-05-01 00:00:00

abstract：:Recent epidemiological and experimental studies have suggested that certain diuretics may have significant anticonvulsant actions. Potential anticonvulsant mechanisms are discussed in light of the effects of these diuretics on electrolyte balance and synaptic signaling. ...

journal_title：Epilepsy currents

authors： Staley KJ

更新日期：2002-03-01 00:00:00

abstract：:Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. J Neurosci. 2018;38(47):10220-10235. doi:10.1523/JNEUROSCI.1590-18.2018. Epub 2018 Oc...

journal_title：Epilepsy currents

authors： Gross C

更新日期：2019-03-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Velíšek L

更新日期：2019-09-01 00:00:00

abstract：:[Box: see text]. ...

journal_title：Epilepsy currents

authors： Lim BC,Hunt RF

更新日期：2019-09-01 00:00:00