Focus on the Focus.

Abstract:

:[Box: see text].

journal_name

Epilepsy Curr

journal_title

Epilepsy currents

authors

Ewell LA

doi

10.1177/1535759719890617

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

54-56

issue

1

eissn

1535-7597

issn

1535-7511

journal_volume

20

pub_type

杂志文章
  • Modeling Pediatric Epilepsy Through iPSC-Based Technologies.

    abstract::In the current review, we discuss the process of modeling pediatric epileptic encephalopathies with a focus on in vitro iPSC-based technologies. We highlight the potential benefits as well as the challenges of these approaches and propose appropriate standards for the field. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.5698/1535-7597.18.4.240

    authors: Simkin D,Kiskinis E

    更新日期:2018-07-01 00:00:00

  • The Roof is Leaking and a Storm is Raging: Repairing the Blood-Brain Barrier in the Fight Against Epilepsy.

    abstract::A large body of evidence that has accumulated over the past decade strongly supports the role of both blood-brain barrier (BBB) dysfunction and perivascular inflammation in the pathophysiology of epilepsy. Recent preclinical studies indicate that prolonged seizure- or brain injury-induced BBB dysfunction and subsequen...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759719844750

    authors: Gorter JA,Aronica E,van Vliet EA

    更新日期:2019-05-01 00:00:00

  • Losing Balance Over a Fatty Acid.

    abstract::Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. J Neurosci. 2018;38(47):10220-10235. doi:10.1523/JNEUROSCI.1590-18.2018. Epub 2018 Oc...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719835664

    authors: Gross C

    更新日期:2019-03-01 00:00:00

  • The Insula and Its Epilepsies.

    abstract::Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Insular seizures with perisylvian sp...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759718822847

    authors: Jobst BC,Gonzalez-Martinez J,Isnard J,Kahane P,Lacuey N,Lahtoo SD,Nguyen DK,Wu C,Lado F

    更新日期:2019-01-01 00:00:00

  • Imaging of serotonin mechanisms in epilepsy.

    abstract::Advances in positron emission tomography (PET) techniques have allowed the measurement and imaging of neurotransmitter synthesis, transport, and receptor binding to be performed in vivo. With regard to epileptic disorders, imaging of neurotransmitter systems not only assists in the identification of epileptic foci for...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7511.2005.00064.x

    authors: Chugani HT,Chugani DC

    更新日期:2005-11-01 00:00:00

  • Goldilocks Zone of Ictal Onset: Partially Recovered Synapses Provide the Kindling to Fuel Ictal Activity.

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719869670

    authors: Subramanian D,Santhakumar V

    更新日期:2019-09-01 00:00:00

  • Epileptogenesis in the Dysplastic Brain: A Revival of Familiar Themes.

    abstract::Brain malformations are now widely recognized in many forms of epilepsy. To investigate how malformed brain regions participate in the generation of seizure activity researchers have focused on animal models. Here we describe recent advances in this field. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1046/j.1535-7597.2001.00011.x

    authors: Baraban SC

    更新日期:2001-09-01 00:00:00

  • The System xc- Cystine/Glutamate Antiporter: An Exciting Target for Antiepileptogenic Therapy?

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759719891983

    authors: Gallagher M

    更新日期:2020-01-01 00:00:00

  • Is it safe to use a diuretic to treat seizures early in development ?

    abstract::There has been considerable interest in using bumetanide, a diuretic chloride importer NKCC1 antagonist, to reduce intracellular chloride ([Cl(-)](i)) in epileptic neurons, thereby shifting the polarity of GABA from excitatory to inhibitory and ameliorating the actions of GABA-acting antiepileptic drugs. However, a re...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.5698/1535-7511-11.6.192

    authors: Ben-Ari Y,Tyzio R

    更新日期:2011-11-01 00:00:00

  • Brain-derived neurotrophic factor and epilepsy--a missing link?

    abstract::It has been known for some time that brain-derived neurotrophic factor (BDNF) is critical to normal development of the CNS, and more recently, studies also have documented the ability of BDNF to modify adult CNS structure and function. Therefore, it is no surprise that BDNF has been linked to diseases, such as epileps...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7511.2005.05312.x

    authors: Scharfman HE

    更新日期:2005-05-01 00:00:00

  • An update on antiepileptic drugs and suicide: are there definitive answers yet?

    abstract::In 2008, the Food and Drug Administration (FDA) issued a warning that any and all antiepileptic drugs (AEDs) might increase the risk of suicidal ideation, suicide attempt, and completed suicide. Considerable confusion and concern followed regarding the use of these drugs, in general, and specifically for people with e...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7511.2010.01382.x

    authors: Hesdorffer DC,Berg AT,Kanner AM

    更新日期:2010-11-01 00:00:00

  • Depression in epilepsy: a neurobiologic perspective.

    abstract::Depression is the most frequent psychiatric comorbidity in patients with epilepsy. By the same token, patients with depression are at higher risk of developing epilepsy than are controls. Such bidirectional relations raise the question of whether both disorders share common pathogenic mechanisms, presenting with commo...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7597.2005.05106.x

    authors: Kanner AM

    更新日期:2005-01-01 00:00:00

  • Efficacy of new antiepileptic drugs.

    abstract::Regarding efficacy of new antiepileptic drugs (AEDs) for seizure control, there are three important clinical questions. How effective are new AEDs when corrected for the efficacy of placebo? And even more important: How do new AEDs fare in terms of seizure remission compared with established agents? And finally: Have ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.5698/1535-7511-11.1.9

    authors: Schmidt D

    更新日期:2011-01-01 00:00:00

  • Don't Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy.

    abstract::Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897. BACKGROUND:Cannabidiol has been used for treatment-resistant seizures in patients with severe early-onset epilepsy. We investigated the efficacy and safe...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719835671

    authors: Perry MS

    更新日期:2019-03-01 00:00:00

  • Continuous EEG Monitoring-The Neurologist's Crystal Ball.

    abstract::Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T. Clin Neurophysiol. 2018;129:1660-1668. https://doi.org/10.1016/j.clinph.2...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759718822037

    authors: Husain AM

    更新日期:2019-01-01 00:00:00

  • Diuretics as Antiepileptic Drugs: Should We Go with the Flow?

    abstract::Recent epidemiological and experimental studies have suggested that certain diuretics may have significant anticonvulsant actions. Potential anticonvulsant mechanisms are discussed in light of the effects of these diuretics on electrolyte balance and synaptic signaling. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1046/j.1535-7597.2002.00018.x

    authors: Staley KJ

    更新日期:2002-03-01 00:00:00

  • Is Targeting of Compensatory Ion Channel Gene Expression a Viable Therapeutic Strategy for Dravet Syndrome?

    abstract::Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome Ritter-Makinson S, Clemente-Perez A, Higashikubo B, Cho FS, Holden SS, Bennett E, Chkhaidze A, Eelkman Rooda OHJ, Cornet MC, Hoebeek FE, Yamakawa K, Cilio MR, Delord B, Paz JT. Cell Rep. 2019;26(1):54-64.e6. doi:10.1016/j.celrep.2018.12.018. L...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719844780

    authors: Isom LL

    更新日期:2019-05-01 00:00:00

  • New developments in antiepileptic drug resistance: an integrative view.

    abstract::Current theories on drug resistance in epilepsy include the drug transporter hypothesis, the drug target hypothesis, and a novel approach called the inherent severity model of epilepsy, which posits that the severity of the disease determines its relative response to medication. Valuable as each of these hypotheses is...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7511.2008.01289.x

    authors: Schmidt D,Löscher W

    更新日期:2009-03-01 00:00:00

  • From Standard of Care to Personalized (Art of) Medicine: Two Novel GABA-A Receptor β3 Subunit Mutations Associated With Epilepsy Syndromes.

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759719889624

    authors: Velisek L

    更新日期:2020-01-01 00:00:00

  • Treatment of Refractory Convulsive Status Epilepticus: A Comprehensive Review by the American Epilepsy Society Treatments Committee.

    abstract:PURPOSE:Established tonic-clonic status epilepticus (SE) does not stop in one-third of patients when treated with an intravenous (IV) benzodiazepine bolus followed by a loading dose of a second antiseizure medication (ASM). These patients have refractory status epilepticus (RSE) and a high risk of morbidity and death. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759720928269

    authors: Vossler DG,Bainbridge JL,Boggs JG,Novotny EJ,Loddenkemper T,Faught E,Amengual-Gual M,Fischer SN,Gloss DS,Olson DM,Towne AR,Naritoku D,Welty TE

    更新日期:2020-09-01 00:00:00

  • Do interictal spikes sustain seizures and epileptogenesis?

    abstract::Interictal spiking is seen in the EEG of epileptic patients between seizures. To date, the roles played by interictal events in seizure occurrence and in epileptogenesis remain elusive. While interictal spikes may herald the onset of electrographic seizures, experimental data indicate that hippocampus-driven intericta...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1111/j.1535-7511.2006.00146.x

    authors: Avoli M,Biagini G,de Curtis M

    更新日期:2006-11-01 00:00:00

  • It's a Storm, It's a Gale: Epilepsy Initiation From the Corticostriatal Circuit.

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719870514

    authors: Velíšek L

    更新日期:2019-09-01 00:00:00

  • Strokes or Seizures? What's the Score?

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759719889625

    authors: Bermeo-Ovalle A

    更新日期:2020-01-01 00:00:00

  • Epilepsy Therapy Goes Viral.

    abstract::[Box: see text]. ...

    journal_title:Epilepsy currents

    pub_type: 评论,杂志文章

    doi:10.1177/1535759719870506

    authors: Lim BC,Hunt RF

    更新日期:2019-09-01 00:00:00

  • Ketogenic Dietary Therapy Controversies for Its Second Century.

    abstract::As the ketogenic diet approaches 100 years of continuous use, we reflect on its successes and consider new avenues of research for the next century. One controversial question is regarding whether ketogenic dietary therapies could be successful first-line treatments for epilepsy. Second, is it possible to mimic the me...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.1177/1535759719890337

    authors: Kossoff E,Cervenka M

    更新日期:2020-05-01 00:00:00

  • Epilepsy Treatment: A Futurist View.

    abstract::Advances in epilepsy treatment are occurring at a rapid pace, and it is challenging for us to keep up with the latest in our field. As we struggle to keep up with the literature and concentrate on our own research and clinical work, we often fail to exercise our imagination and envision what our field will be like in ...

    journal_title:Epilepsy currents

    pub_type: 杂志文章

    doi:10.5698/1535-7597.17.4.204

    authors: Privitera M

    更新日期:2017-07-01 00:00:00