Abstract:
INTRODUCTION:Despite the significant advances in the pharmacological and interventional management of patients with cardiovascular disease (CVD) over the last decades, cardiovascular mortality remains the leading cause of death. Large randomized clinical trials have investigated the efficacy and safety of different antithrombotic medications in patients with CVD. Although female gender is generally underrepresented in these clinical trials, most analyses clearly indicate that both men and women may accrue therapeutic benefits from antithrombotic management strategies. AREAS COVERED:This review aims to provide a comprehensive and focused update on gender-related comparative clinical studies of antithrombotic therapies in patients suffering from CVD. EXPERT OPINION:Current evidence supports the understanding of a similar therapeutic effect between genders with signals of an increased risk of bleeding in women. However, important gaps in evidence exist due to the overall limited percentage of women that have been enrolled in randomized controlled trials. A greater awareness of gender-related issues in antithrombotic therapy should be promoted among physicians and further evidence from large clinical trials looking at the safety and efficacy balance of different antithrombotic strategies in women is warranted.
journal_name
Expert Opin Drug Safjournal_title
Expert opinion on drug safetyauthors
Romano S,Buccheri S,Mehran R,Angiolillo DJ,Capodanno Ddoi
10.1080/14740338.2018.1524869subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1041-1052issue
10eissn
1474-0338issn
1744-764Xjournal_volume
17pub_type
杂志文章,评审abstract:INTRODUCTION:In settings where HIV is prevalent in heterosexual populations, pregnancy and postpartum breastfeeding periods can be associated with substantial HIV acquisition risk. Pre-exposure prophylaxis (PrEP) with daily oral tenofovir disoproxil fumarate (TDF)/emtricitabine is an attractive HIV prevention option fo...
journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,meta分析,评审
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
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pub_type: 社论
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journal_title:Expert opinion on drug safety
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journal_title:Expert opinion on drug safety
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1517/14740338.2011.559161
更新日期:2011-05-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1517/14740338.2011.529898
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