The safety of treatment options for acute bacterial skin and skin structure infections.

Abstract:

INTRODUCTION:Acute bacterial skin and skin-structure infections (ABSSSI) may develop in both in-patients and out-patients, possibly with a severe clinical presentation. Since most phase 3 randomized clinical trials have shown non-inferiority in efficacy across different agents, considerations regarding their different safety profiles inevitably play a crucial role in the everyday choice about which of them should be employed for the treatment of ABSSSI. AREAS COVERED:In this review, the authors discuss the safety profile of different treatment options for ABSSSI. EXPERT OPINION:The spread of methicillin-resistant Staphylococcus aureus (MRSA) in the last decades has inevitably influenced the therapeutic approach to ABSSSI. Adequate knowledge of the peculiar toxicity profile of each drug active against MRSA is essential for guiding, monitoring and managing adverse events, in turn reducing any unfavorable impact of toxicity on patients' outcomes. In the next five years, potential toxicity will play a critical role in establishing the best available therapy for each specific patient, together with consideration regarding the possibility of avoiding hospitalization or allowing a switch from intravenous to oral therapy and early discharge.

journal_name

Expert Opin Drug Saf

authors

Bassetti M,Peghin M,Castaldo N,Giacobbe DR

doi

10.1080/14740338.2019.1621288

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

635-650

issue

8

eissn

1474-0338

issn

1744-764X

journal_volume

18

pub_type

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