Abstract:
:Head and neck skin cancer surgery using a full thickness skin graft is a common procedure. Evidence concerning the effects of perioperative antithrombotic treatment on complications is limited. The aim of this study was to evaluate whether perioperative antithrombotic treatment is associated with risk of necrosis, bleeding or infection after full thickness skin graft surgery. Retrospective single-center cohort study with medical records review. Patients operated with a head and neck full thickness skin graft in 2010 and 2013-2015 had available data and were included. Any antithrombotic treatment was continued and all patients were routinely followed-up on days 7-10 after surgery. Data on demographics, concurrent disease, clinical characteristics, antithrombotic medications and postoperative necrosis, bleeding and infection were collected from electronic medical records. Associations with complications were examined using multivariate logistic regression adjusted for age, sex, reoperation, size of excision, site of surgery and concurrent disease. In total, 302 patients (53% women) were included. Antithrombotic treatment (n = 125 patients) was not associated with higher adjusted risk of total complications in multivariate analysis (OR 0.70; 95% CI: 0.34-1.46). In subgroup analyses, the total risk was not increased in patients on aspirin (OR 0.76; 95% CI: 0.39-1.48) or warfarin (OR 1.20; 95% CI: 0.47-3.10). In the warfarin subgroup (N = 26), there was a statistically non-significant trend towards increased risk of graft necrosis. This study supports that aspirin and warfarin should not be discontinued prior to head and neck full thickness skin graft surgery.
journal_name
J Plast Surg Hand Surgjournal_title
Journal of plastic surgery and hand surgeryauthors
Hasselgren M,Runer T,Janson P,Ekström Mdoi
10.1080/2000656X.2018.1498789subject
Has Abstractpub_date
2018-12-01 00:00:00pages
333-337issue
6eissn
2000-656Xissn
2000-6764journal_volume
52pub_type
杂志文章abstract::Collagenase Clostridium histolyticum (CCH) is a non-surgical, efficacious therapy for Dupuytren's contracture (DC). This study evaluated the efficacy and safety of CCH in patients with previous DC surgery. Data from 12 CCH clinical trials were pooled. At screening, patients provided details about the type/date of prev...
journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,meta分析
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.779581
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.779801
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.668325
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journal_title:Journal of plastic surgery and hand surgery
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doi:10.3109/2000656X.2013.812763
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1856672
更新日期:2020-12-16 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1089877
更新日期:2016-01-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.754622
更新日期:2014-02-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2015.1119697
更新日期:2016-06-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.753080
更新日期:2013-09-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
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doi:10.3109/2000656X.2014.964724
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2017.1281820
更新日期:2017-10-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1838295
更新日期:2020-11-06 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.698416
更新日期:2012-09-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.683796
更新日期:2012-09-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
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doi:10.3109/2000656X.2011.558735
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journal_title:Journal of plastic surgery and hand surgery
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.787935
更新日期:2013-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.742020
更新日期:2013-04-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2016.1194280
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章,多中心研究
doi:10.3109/2000656X.2013.767202
更新日期:2013-10-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2019.1693391
更新日期:2020-04-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2013.776561
更新日期:2013-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.3109/2000656X.2012.729652
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
doi:10.1080/2000656X.2020.1791893
更新日期:2020-12-01 00:00:00
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journal_title:Journal of plastic surgery and hand surgery
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00