当前位置： SCI文献检索 > Taiwanese Journal of Obstetrics & Gynecology期刊下所有文献 > Significant relationship of combined ACP1/PTPN22 genotype variants with the growth of uterine leiomyomas.

Significant relationship of combined ACP1/PTPN22 genotype variants with the growth of uterine leiomyomas.

Abstract：

OBJECTIVE:To analyze the interaction between ACP1 and PTPN22 concerning their effects on the growth of the tumor. In previous paper we have shown (i) that ACP1*B/*B genotype of ACP1 is negatively associated with the growth of leiomyomas and (ii) that there is a negative association of *C/*C genotype of PTPN22 with tumor growth. MATERIALS AND METHODS:Two hundred and three White women from the population of Rome with symptomatic leiomyomas were recruited in the University of Rome Tor Vergata. All subjects gave consent for the participation in the study that was approved by the Council of Department. ACP1 and PTPN22 genotypes were determined by DNA analysis. RESULTS:The proportion of women with small leiomyomas decreases with the decrease of the number of protective factors and it is 37.2% in women carrying the joint genotype ACP1*B/*B-PTPN22 *C/*C (two protective factors) and 0% in women carrying no protective factors. Three way contingency table analysis by a log linear model has shown no evidence of epistatic interaction between the two genetic systems but a highly significant cooperative effect on the dimension of leiomyomas. There is a highly significant negative correlation between the number of protective factors and the dimension of leiomyomas with a minimum (cm 4.74) in women carrying the joint genotype ACP1*B/B-PTPN22 *C/*C and a maximum (cm 7.25) in women carrying no protective factors. CONCLUSION:The present study suggests a cooperative interaction between ACP1 and PTPN22 concerning their effects on the growth of uterine leiomyomas. The determination of the genotype of the two systems may help to evaluate the risk of clinical manifestations of this common benign tumor.

journal_name

Taiwan J Obstet Gynecol

journal_title

Taiwanese journal of obstetrics & gynecology

authors

Gloria-Bottini F,Neri A,Pietropolli A,Magrini A,Bottini E

doi

10.1016/j.tjog.2018.06.017

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

567-569

issue

4

eissn

1028-4559

issn

1875-6263

pii

S1028-4559(18)30135-9

journal_volume

57

pub_type

杂志文章

相关文献

Taiwanese Journal of Obstetrics & Gynecology文献大全
  • Triplet pregnancy complicated with one hydatidiform mole and preeclampsia in a 46,XY female with gonadal dysgenesis.

    abstract：OBJECTIVE:We present a case of triplet pregnancy with a complete hydatidiform mole, a condition carrying a significant risk to both mother and fetuses and, therefore, raising an important issue on prenatal care. CASE REPORT:A 36-year-old patient with gonadal dysgenesis and a 46,XY karyotype successfully conceived a tr...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(08)60034-0

    authors： Ko PC,Peng HH,Soong YK,Chang SD

    更新日期：2007-09-01 00:00:00

  • Validation of a high-throughput and robust technique: BACs-on-beads assay (KaryoLite BoBs) for pre-implantation aneuploidy screening.

    abstract：OBJECTIVE:This study aims to validate the BACs-on-Beads (BoB) technology as a robust and high throughput method for pre-implantation genetic screening (PGS) for aneuploidy. MATERIAL AND METHODS:The performances with respect to the sensitivity, specificity, success rate and detection rate of this technique from new BoB...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2017.01.011

    authors： Kong GWS,Ma Y,Ou J,Kwok YKY,Wang W,Yeung QSY,Wong CKM,Li Q,Xu W,Lu W,Li H,Li TC,Choy KW

    更新日期：2017-08-01 00:00:00

  • Vaginoscopic hysteroscopy in management for women with post-menopausal vaginal bleeding.

    abstract：OBJECTIVES:The feasibility of vaginoscopic hysteroscopy combined with office endometrial biopsy after ultrasonography for management of post-menopausal vaginal bleeding (PMB). MATERIALS AND METHODS:A prospective observational study of with PMB whom attending the Outpatient Clinic of Kang Ning Hospital during a four mo...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2019.05.012

    authors： Lee YL,Bai YS,Yin CS

    更新日期：2019-07-01 00:00:00

  • The effects of absent or reversed end-diastolic umbilical artery Doppler flow velocity.

    abstract：:Abnormal umbilical artery flow with absent or reversed end-diastolic velocity (AREDV) during pregnancy is a strong indication of placental insufficiency. When AREDV occurs prenatally, a close follow-up or expeditious delivery should be contemplated. AREDV in the umbilical artery is associated with intraventricular hem...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/S1028-4559(09)60294-1

    authors： Wang KG,Chen CY,Chen YY

    更新日期：2009-09-01 00:00:00

  • An analysis of the maternal and infant outcomes in the delayed interval delivery of twins.

    abstract：OBJECTIVE:To investigate the treatment methods used for the delayed interval delivery of twins and to evaluate the maternal and infant outcomes. MATERIALS AND METHODS:The clinical data of 5 patients that underwent delayed interval delivery of twins at Fujian Maternal and Child Health Hospital from 2014 to 2018 were an...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2020.03.004

    authors： Zheng XQ,Yan JY,Xu RL,Wang XC,Li LY,Lin Z

    更新日期：2020-05-01 00:00:00

  • Effective reduction in inadequate Pap smears by using a saline-lubricated speculum and two glass slides.

    abstract：OBJECTIVE:The aim of the study was to propose a method using saline lubrication and two glass slides to reduce the proportion of inadequate Pap smears. MATERIALS AND METHODS:This was a retrospective study of patients at a medical center in eastern Taiwan that performs 5000-6000 Pap smears annually. The extracted data ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2020.09.018

    authors： Chen CJ,Hong MK,Ding DC

    更新日期：2020-11-01 00:00:00

  • A comparative study of laparoscopic sacrocolpopexy and total vaginal mesh procedure using lightweight polypropylene meshes for prolapse repair.

    abstract：OBJECTIVE:Use of vaginal meshes for treatment of pelvic organ prolapse (POP) remains controversial. A trend toward abdominal approaches and the development of new meshes has been noted. We compared the 1-year results of two different approaches using new lightweight meshes. MATERIALS AND METHODS:Sixty-nine (95.8%) of ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.tjog.2014.07.006

    authors： Liu CK,Tsai CP,Chou MM,Shen PS,Chen GD,Hung YC,Hung MJ

    更新日期：2014-12-01 00:00:00

  • Laparoscopic hysterectomies for large uteri.

    abstract：:Laparoscopic hysterectomies increase recently due to several advantages of minimally invasive surgery. Controversy exists for laparoscopic hysterectomies for large uteri weighing >500g because some reports show increased complications and morbidities and high laparoconversion rate in the past. With familiarity of lapa...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tjog.2011.10.003

    authors： Wu KY,Lertvikool S,Huang KG,Su H,Yen CF,Lee CL

    更新日期：2011-12-01 00:00:00

  • Rapidly growing ovarian endometrioid adenocarcinoma involving the vagina: a case report.

    abstract：OBJECTIVE:We present a rare case of a very rapidly growing stage IV ovarian endometrioid adenocarcinoma involving the uterine cervix and vagina without lymph node involvement. CASE REPORT:A 43-year-old woman visited the hospital with complaints of lower abdominal discomfort and vaginal bleeding over the previous 3 mon...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2011.10.023

    authors： Na S,Hwang J,Lee H,Lee J,Lee D

    更新日期：2011-12-01 00:00:00

  • Longitudinal changes in bone mineral density of healthy elderly women in southern Taiwan.

    abstract：OBJECTIVE:Longitudinal data on bone decline in ethnic Chinese elderly are sparse, especially in healthy, aged women. This study reviews the longitudinal change in bone mineral density (BMD) at the femoral neck, great trochanter, and Ward's triangle in healthy elderly Taiwanese women. MATERIALS AND METHODS:A prospectiv...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2012.08.001

    authors： Chen CH,Kang L,Huang HT,Chang JK,Wu SF,Lin SY,Cheng YM,Chiu HC

    更新日期：2013-03-01 00:00:00

  • Primary malignant mixed müllerian tumor of the ovary.

    abstract：OBJECTIVE:To present a case of malignant mixed müllerian tumor of the ovary, a rare and aggressive ovarian malignant tumor with poor prognosis. CASE REPORT:A 52-year-old woman consulted our outpatient department with complaints of abdominal distention and a firm palpable mass over her lower abdomen. Physical examinati...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(10)60016-2

    authors： Chiu SY,Twu NF,Lai CH,Yen MS,Chao KC

    更新日期：2010-03-01 00:00:00

  • A case of congenital long QT syndrome, type 8, undergoing laparoscopic hysterectomy with general anesthesia.

    abstract：OBJECTIVE:Patients with Long QT syndrome (LQTS) P may present with torsades de pointes, ventricular tachycardia (VT), or ventricular fibrillation (VF) and are at risk of sudden cardiac death. MATERIALS AND METHODS:A 38 y/o female patient with uterus myoma developed VF during laparoscopic assisted vaginal hysterectomy ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2019.05.031

    authors： Chang SL,Chang CT,Hung WT,Chen LK

    更新日期：2019-07-01 00:00:00

  • Factors influencing the abortion interval of second trimester pregnancy termination using misoprostol.

    abstract：OBJECTIVES:To determine the factors influencing the abortion interval (AI) for medical termination of second-trimester pregnancy using misoprostol. MATERIALS AND METHODS:All patients who were admitted for second-trimester pregnancy termination between January 2008 and August 2013 were reviewed. Those who received eith...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.08.008

    authors： Ting WH,Peng FH,Lin HH,Lu HF,Hsiao SM

    更新日期：2015-08-01 00:00:00

  • Comparison of the laparoscopic versus conventional open method for surgical staging of endometrial carcinoma.

    abstract：OBJECTIVE:Although laparoscopic surgery is widely utilized in the treatment of endometrial cancer, its efficacy in staging the cancer is not well established. The aim of this study was to compare staging endometrial cancer with laparoscopic and conventional open methods. MATERIALS AND METHODS:From January 2002 to June...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.02.007

    authors： Chu LH,Chang WC,Sheu BC

    更新日期：2016-04-01 00:00:00

  • Monitoring bladder compliance using end filling detrusor pressure: Clinical results and related factors.

    abstract：OBJECTIVE:To assess the clinical significance of low compliance bladder (LCB) in women with lower urinary tract symptoms. MATERIALS AND METHODS:Medical records of 1490 women undergoing videourodynamic studies (VUSs) were reviewed. Comprehensive medical histories, physical examinations, bladder diaries, and results of ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2015.10.003

    authors： Liao JY,Lin YH,Liang CC,Hsieh WC,Lee SJ,Tseng LH

    更新日期：2015-12-01 00:00:00

  • Galloway-Mowat syndrome: prenatal ultrasound and perinatal magnetic resonance imaging findings.

    abstract：OBJECTIVE:To present prenatal ultrasound and perinatal magnetic resonance imaging (MRI) findings of Galloway-Mowat syndrome. CASE REPORT:A 31-year-old woman, gravida 3, para 2, was referred for genetic counseling at 29 weeks of gestation because of abnormal ultrasound findings and a previous child with Galloway-Mowat ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2011.04.005

    authors： Chen CP,Lin SP,Liu YP,Tsai JD,Chen CY,Shih SL,Tsai FJ,Wu PC,Wang W

    更新日期：2011-06-01 00:00:00

  • A mixture of St. John's wort and sea buckthorn oils regresses endometriotic implants and affects the levels of inflammatory mediators in peritoneal fluid of the rat: A surgically induced endometriosis model.

    abstract：OBJECTIVE:Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and ...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2015.01.006

    authors： İlhan M,Süntar İ,Demirel MA,Yeşilada E,Keleş H,Küpeli Akkol E

    更新日期：2016-12-01 00:00:00

  • Fetal ovarian cysts diagnosed during prenatal ultrasound screening.

    abstract：OBJECTIVE:To discuss the follow-up and management of fetal ovarian cysts (FOCs) and review the current literature. CASE REPORT:A 26-year-old, gravida 2, para 0, abortus 1, Rh-negative patient was diagnosed with bilateral FOCs during ultrasound examination at 32 weeks gestation. Fetal nuchal translucency measured at 12...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/s1028-4559(08)60084-4

    authors： Karaşahin KE,Gezginç K,Ulubay M,Ergün A

    更新日期：2008-06-01 00:00:00

  • Long-term survival outcomes of laparoscopic staging surgery in treating endometrial cancer: 20 years of follow-up.

    abstract：OBJECTIVE:To assess the long-term outcomes of laparoscopic staging surgery (LSS) in treating patients with endometrial carcinoma. MATERIALS AND METHODS:Patients with endometrial cancer who underwent LSS between June 1995 and June 2014 were prospectively registered. Perioperative data, complications, disease recurrence...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2016.04.035

    authors： Lee CL,Kusunoki S,Huang KG,Wu KY,Huang CY,Yen CF

    更新日期：2016-08-01 00:00:00

  • Acute fatty liver of pregnancy in a Taiwanese tertiary care center: a retrospective review.

    abstract：OBJECTIVE:To evaluate the demographics, clinical presentations, laboratory findings, and maternal and fetal outcomes in patients with acute fatty liver of pregnancy. MATERIALS AND METHODS:A retrospective review was conducted of the records of pregnant patients with a diagnosis of acute fatty liver in a tertiary medica...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(10)60033-2

    authors： Lau HH,Chen YY,Huang JP,Chen CY,Su TH,Chen CP

    更新日期：2010-06-01 00:00:00

  • Factors associated with post-partum smoking relapse in Taiwan: A trial of Smoker's helpline.

    abstract：OBJECTIVE:Many women quit smoking during pregnancy resume in postpartum period and difficult to prevent. No studies had focused on their psychosocial response in Taiwan. We analyzed data from a trial of Taiwan Smoker's Helpline (TSH) to determine factors associated with smoking relapse after delivery. MATERIALS AND ME...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.tjog.2019.07.015

    authors： Lin CL,Lee TS,Hsu CC,Chen CY,Chao E,Shih SF,Hu HY

    更新日期：2019-09-01 00:00:00

  • Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients.

    abstract：OBJECTIVE:The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a his...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2015.06.013

    authors： Eser A,Inegol Gumus I,Erdamar H,Kaygusuz I,Yildirim M,Usluogullari B,Duran Erdolu M,Simavli SA,Yigitoglu R,Ozturk Turhan N

    更新日期：2016-02-01 00:00:00

  • Acute pancreatitis secondary to primary hyperparathyroidism in a postpartum patient: a case report and literature review.

    abstract：OBJECTIVE:Primary hyperparathyroidism (PHPT) is a rare clinical entity in reproductive women. Unusual hypercalcemia causing pancreatitis in the peripartum period carries significant morbidity to both the fetus and the mother. CASE REPORT:A 38-year-old woman developed a morbid course of intractable intra-abdominal absc...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.tjog.2013.01.029

    authors： Lee CC,Chao AS,Chang YL,Peng HH,Wang TH,Chao A

    更新日期：2014-06-01 00:00:00

  • Acquired uterine vascular abnormalities associated with persistent human chorionic gonadotropin: Experience at a Korean teaching hospital.

    abstract：OBJECTIVE:The aim of this study was to describe our experience with the diagnosis and management of acquired uterine vascular abnormalities associated with persistent human chorionic gonadotropin (hCG). Through this case series, we sought to establish our protocol for the treatment and follow-up of uterine vascular les...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.06.008

    authors： Ju da H,Yi SW,Sohn WS,Lee SS

    更新日期：2015-12-01 00:00:00

  • An association study of interleukin-4 gene and preeclampsia in Taiwan.

    abstract：OBJECTIVE:To test whether the interleukin-4 (IL-4) gene polymorphisms could be used as markers of susceptibility for preeclampsia in Taiwan. MATERIALS AND METHODS:This study included 78 women with preeclampsia and 125 normal controls. A polymerase chain reaction was used to analyze the variable number of tandem repeat...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2014.04.017

    authors： Kang L,Chen CH,Yu CH,Chang CH,Chang FM

    更新日期：2014-06-01 00:00:00

  • Gestational choriocarcinoma with renal and pulmonary metastases lacking a primary uterine origin.

    abstract：OBJECTIVE:We describe a case of gestational choriocarcinoma metastasized to the kidney and lung, which presented initially as refractory hematuria after a term pregnancy 5 years earlier. CASE REPORT:A 35-year-old woman, G2P1, with a previous history of full-term pregnancy in 2009, presented to the emergency department...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2015.08.028

    authors： Li HM,Hou WC,Lai YJ,Kao CC,Chao TK,Yu MH,Su HY

    更新日期：2016-12-01 00:00:00

  • Use of mifepristone and sublingual misoprostol for early medical abortion.

    abstract：OBJECTIVE:Existing drug-induced abortion techniques involve oral administration of 200 mg of mifepristone, followed by oral administration of 600 microg of misoprostol 48 hours later, but the effects are variable. As revealed by recent research, sublingual and oral administrations of misoprostol are equally efficacious...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/S1028-4559(09)60251-5

    authors： Lin M,Li YT,Chen FM,Wu SF,Tsai CW,Chen TH,Kuo TC

    更新日期：2006-12-01 00:00:00

  • Comparison of whole genome amplification methods for further quantitative analysis with microarray-based comparative genomic hybridization.

    abstract：OBJECTIVE:Whole genome amplification (WGA) is a crucial procedure for genomic DNA analysis from limited sources, such as in forensic analysis, embryo biopsy for preimplantation genetic diagnosis, or needle aspiration biopsies. Several strategies for WGA have been developed for either genotyping or microarray-based comp...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/S1028-4559(08)60052-2

    authors： Lee YS,Tsai CN,Tsai CL,Chang SD,Hsueh DW,Liu CT,Ma CC,Lin SH,Wang TH,Wang HS

    更新日期：2008-03-01 00:00:00

  • Alobar holoprosencephaly, cebocephaly, and micropenis in a Klinefelter fetus of a diabetic mother.

    abstract：OBJECTIVE:Coexistence of Klinefelter syndrome and holoprosencephaly (HPE) is rare. We report alobar HPE, cebocephaly, and micropenis in a Klinefelter fetus of a mother with type 2 diabetes mellitus with obesity and poor metabolic control. CASE REPORT:A 38-year-old woman was referred for therapy of type 2 diabetes mell...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2012.09.021

    authors： Chen CP,Su TH,Chern SR,Su JW,Lee CC,Wang W

    更新日期：2012-12-01 00:00:00

  • The effects of resveratrol on ovarian hyperstimulation syndrome in a rat model.

    abstract：OBJECTIVE:The aim of the present study was to investigate effects of resveratrol (RSV) over ovarian hyperstimulation syndrome (OHSS) in rat model. MATERIALS AND METHODS:24 female Wistar rats (22 days old) were divided into four groups. Group 1 (control group; n = 6) received 0.1 ml intraperitoneal (IP) saline from day...

    journal_title：Taiwanese journal of obstetrics & gynecology

    pub_type： 杂志文章

    doi：10.1016/j.tjog.2018.04.010

    authors： Ozgur S,Oktem M,Altinkaya SO,Oktem EO,Cenksoy C,Erdem O,Elbeg S,Helvaci A,Erdem A,Erdem M

    更新日期：2018-06-01 00:00:00