Abstract：
OBJECTIVE:To analyze the interaction between ACP1 and PTPN22 concerning their effects on the growth of the tumor. In previous paper we have shown (i) that ACP1*B/*B genotype of ACP1 is negatively associated with the growth of leiomyomas and (ii) that there is a negative association of *C/*C genotype of PTPN22 with tumor growth. MATERIALS AND METHODS:Two hundred and three White women from the population of Rome with symptomatic leiomyomas were recruited in the University of Rome Tor Vergata. All subjects gave consent for the participation in the study that was approved by the Council of Department. ACP1 and PTPN22 genotypes were determined by DNA analysis. RESULTS:The proportion of women with small leiomyomas decreases with the decrease of the number of protective factors and it is 37.2% in women carrying the joint genotype ACP1*B/*B-PTPN22 *C/*C (two protective factors) and 0% in women carrying no protective factors. Three way contingency table analysis by a log linear model has shown no evidence of epistatic interaction between the two genetic systems but a highly significant cooperative effect on the dimension of leiomyomas. There is a highly significant negative correlation between the number of protective factors and the dimension of leiomyomas with a minimum (cm 4.74) in women carrying the joint genotype ACP1*B/B-PTPN22 *C/*C and a maximum (cm 7.25) in women carrying no protective factors. CONCLUSION:The present study suggests a cooperative interaction between ACP1 and PTPN22 concerning their effects on the growth of uterine leiomyomas. The determination of the genotype of the two systems may help to evaluate the risk of clinical manifestations of this common benign tumor.
journal_name
Taiwan J Obstet Gynecoljournal_title
Taiwanese journal of obstetrics & gynecologyauthors
Gloria-Bottini F,Neri A,Pietropolli A,Magrini A,Bottini Edoi
10.1016/j.tjog.2018.06.017subject
Has Abstractpub_date
2018-08-01 00:00:00pages
567-569issue
4eissn
1028-4559issn
1875-6263pii
S1028-4559(18)30135-9journal_volume
57pub_type
杂志文章abstract：OBJECTIVE:To compare the efficacy of carbetocin and oxytocin on hemorrhage-related changes in women with cesarean deliveries (CS) for different indications. MATERIALS AND METHODS:A retrospective cohort study was conducted on 1568 women with CS before labor onset (elective CS, n = 1153) or during labor (intrapartum CS,...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2018.08.011
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:To analyze the benefits of external cephalic version (ECV) with epidural analgesia at term and labor induction just after the procedure. MATERIALS AND METHODS:This is a retrospective observational study with patients who did not want trying a breech vaginal delivery and decided trying an ECV with epidural an...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.04.018
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:To investigate the treatment methods used for the delayed interval delivery of twins and to evaluate the maternal and infant outcomes. MATERIALS AND METHODS:The clinical data of 5 patients that underwent delayed interval delivery of twins at Fujian Maternal and Child Health Hospital from 2014 to 2018 were an...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2020.03.004
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:To assess the clinical significance of low compliance bladder (LCB) in women with lower urinary tract symptoms. MATERIALS AND METHODS:Medical records of 1490 women undergoing videourodynamic studies (VUSs) were reviewed. Comprehensive medical histories, physical examinations, bladder diaries, and results of ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2015.10.003
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:We describe a case of gestational choriocarcinoma metastasized to the kidney and lung, which presented initially as refractory hematuria after a term pregnancy 5 years earlier. CASE REPORT:A 35-year-old woman, G2P1, with a previous history of full-term pregnancy in 2009, presented to the emergency department...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2015.08.028
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the rates of infection of asymptomatic fetuses and mothers through fetal cord blood and maternal blood examination results. MATERIALS AND METHODS:Quantitative PCR (Q-PCR) was used to detect pathogens in maternal peripheral blood and fetal cord blood after delivery of term pregnancy at Buddhist Tz...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60207-2
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:To compare trends and rates of cesarean section delivery by indication in one academic center. MATERIALS AND METHODS:A retrospective analysis of the indications of all cesarean sections performed in Edith Wolfson Medical Center, Holon, Israel, a tertiary healthcare university facility, during 1997-2012 was d...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.12.014
更新日期：2016-08-01 00:00:00
abstract：OBJECTIVE:We present a rare case of a very rapidly growing stage IV ovarian endometrioid adenocarcinoma involving the uterine cervix and vagina without lymph node involvement. CASE REPORT:A 43-year-old woman visited the hospital with complaints of lower abdominal discomfort and vaginal bleeding over the previous 3 mon...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2011.10.023
更新日期：2011-12-01 00:00:00
abstract：OBJECTIVE:Melilotus officinalis (L.) Pall. is commonly used for treating bronchitis, painful menstruation, hemorrhoids, kidney stones, ulcers of the eyes, earache, and hardening and swelling of uterus. The European Medicines Agency reported the use of M. officinalis orally against stomach ache, gastric ulcer, and disor...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2020.01.008
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:Human papillomavirus (HPV) has been recognized as the major etiologic agent of cervical squamous cell carcinoma. However, it has been demonstrated that HPV infection is usually a self-limited process and does not lead to significant epithelial lesions or cancer. Recent data indicate that persistent high-risk ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.06.001
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:This study was aimed to identify the physical and mental state of women after delivery, to investigate the factors that influence those, and to examine the effects of postpartum care performance, which is traditionally believed to be appropriate care in Korea, on women's physical and mental status. MATERIALS...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.04.030
更新日期：2015-08-01 00:00:00
abstract：OBJECTIVE:Burkitt's lymphoma (BL) occurs mostly in children; bilateral ovarian involvement mimicking a gynecologic malignancy in adults is extremely rare. Here, we report a patient with BL mimicking a gynecologic tumor. CASE REPORT:A 50-year-old Taiwanese woman presented with the complaint of persistent lower abdomina...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60217-5
更新日期：2006-06-01 00:00:00
abstract：OBJECTIVE:To present prenatal ultrasound and perinatal magnetic resonance imaging (MRI) findings of Galloway-Mowat syndrome. CASE REPORT:A 31-year-old woman, gravida 3, para 2, was referred for genetic counseling at 29 weeks of gestation because of abnormal ultrasound findings and a previous child with Galloway-Mowat ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2011.04.005
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:In nonimmune pregnant woman, the primary infection with parvovirus B19 may lead to transplacental transmission to the fetus with variable outcomes, including congenital anemia, hydrops fetalis, fetal death or spontaneous resolution. CASE REPORT:The first case was of a 28-year-old woman, gravida 2, para 1, wh...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/s1028-4559(08)60014-5
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To discuss the follow-up and management of fetal ovarian cysts (FOCs) and review the current literature. CASE REPORT:A 26-year-old, gravida 2, para 0, abortus 1, Rh-negative patient was diagnosed with bilateral FOCs during ultrasound examination at 32 weeks gestation. Fetal nuchal translucency measured at 12...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/s1028-4559(08)60084-4
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:To report a case of a ruptured tubo-ovarian abscess which induced septic shock in a postmenopausal woman. CASE REPORT:A 53-year-old postmenopausal woman was transferred to our emergency department for drowsiness, hypotension, and lower abdominal discomfort. Transabdominal sonography and computed tomography s...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/s1028-4559(09)60202-3
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:Mucinous ovarian carcinoma (MOC) is an uncommon subtype of epithelial ovarian cancers, and the pathogenesis is still poorly understood because of its rarity. We conducted a gene set-based analysis to investigate the pathogenesis of MOC by integrating microarray gene expression datasets based on the regularity...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2016.12.016
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Difficulties often encountered during intubation in extremely low birth-weight (ELBW) neonates requiring resuscitation at birth because of the smaller airway and the pressure from the limited number of attempts before hemodynamic instability occurs. CASE REPORT:We evaluated two pregnant women at 26 weeks of ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.07.001
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:The purpose of the study was to compare the Quinn's Advantage fertilization medium (Q1) and the tissue culture medium 199 (TCM199) for in vitro maturation (IVM) of oocytes and ammonium production during IVM. MATERIALS AND METHODS:The immature murine oocytes were randomly added into Q1 and TCM199. Ammonium co...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2013.12.001
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:The study aimed to explore the changes in mitochondrial DNA (mtDNA) copy number, collagen, and matrix metalloproteinase (MMPs) expression with pelvic organ prolapse (POP) in the uterosacral ligaments of premenopausal women. MATERIALS AND METHODS:A group of 56 premenopausal women, all younger than 52 years of...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2014.04.032
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE:It is known that most cases of ovarian hyperstimulation syndrome (OHSS) are associated with the therapies for ovulation induction. However, OHSS may rarely be associated with a spontaneous ovulatory cycle, usually in the case of multiple gestations, hypothyroidism or polycystic ovary syndrome. CASE REPORT:A ...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60241-2
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVE:Non-Hodgkins lymphomas (NHL) rarely affect the vagina. As a result, a standard treatment has not been defined. CASE REPORT:A 34-year-old female virgin patient with a primary vaginal NHL stage IEA, diffuse large cell B lineage, showed an excellent response to cytotoxic chemotherapy (cyclophosphamide, doxorubi...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(08)60135-7
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:In this study, we investigated the developmental potential of single blastomeres that were obtained from 4-cell mice embryos that were split during the blastocyst stage. MATERIALS AND METHODS:Imprinting Control Region (ICR) mice (age: 6-8 weeks), were superovulated and mated with a single fertile male of the...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2012.04.012
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:Endometriosis-associated epithelial ovarian cancer (EOC) is a specific category of EOC, containing either endometrioid or clear cell carcinoma subtype. The characteristic of endometriosis-associated EOC includes an early stage at the diagnosis, presence of single histology type, and better prognosis. The sync...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type：
doi：10.1016/j.tjog.2020.03.024
更新日期：2020-05-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to describe the natural history and outcomes of fetal congenital cystic adenomatoid malformation (CCAM) of the lung in three antenatally diagnosed cases. CASE REPORT:Three women whose fetuses had CCAM of the lung between 2004 and 2006 chose to continue their pregnancies. We followed...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/S1028-4559(09)60304-1
更新日期：2009-09-01 00:00:00
abstract：:Cervical cancer is not only the most frequently reported cancer among women, but also the most common female genital tract neoplasm in Taiwan. Early detection is effective, because the development, maintenance and progression of precursor lesions (cervical intraepithelial neoplasia [CIN]) evolve slowly into invasive c...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,评审
doi：10.1016/S1028-4559(08)60004-2
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:This paper aims to present molecular cytogenetic and epigenetic evaluation of placental mesenchymal dysplasia (PMD). MATERIALS AND METHODS:A 33-year-old woman was referred to the hospital at 18 weeks of gestation because of a multicystic mass in the placenta. Ultrasound showed a normal amount of amniotic flu...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2013.10.036
更新日期：2014-03-01 00:00:00
abstract：OBJECTIVE:Many women quit smoking during pregnancy resume in postpartum period and difficult to prevent. No studies had focused on their psychosocial response in Taiwan. We analyzed data from a trial of Taiwan Smoker's Helpline (TSH) to determine factors associated with smoking relapse after delivery. MATERIALS AND ME...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.tjog.2019.07.015
更新日期：2019-09-01 00:00:00
abstract：OBJECTIVE:This study aims to validate the BACs-on-Beads (BoB) technology as a robust and high throughput method for pre-implantation genetic screening (PGS) for aneuploidy. MATERIAL AND METHODS:The performances with respect to the sensitivity, specificity, success rate and detection rate of this technique from new BoB...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2017.01.011
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:Pain affects many cancer patients in advancing stages, lowering the level of their quality of life. Morphine has long been the "gold standard" for the treatment of cancer pain; however, its side effects, particularly sedation and cognitive impairment at high doses, have encouraged the use of "opioid rotation"...
journal_title：Taiwanese journal of obstetrics & gynecology
pub_type： 杂志文章
doi：10.1016/j.tjog.2011.01.006
更新日期：2011-03-01 00:00:00
