Montelukast and budesonide combination for children with chronic cough-variant asthma.

Abstract:

:This study investigated the effectiveness and safety of montelukast combined budesonide (MCB) treatment for children with chronic cough-variant asthma (CCVA).In total, 82 cases of children with CCVA, aged 4 to 11 years were included in this study. All cases received either MCB or budesonide alone between May 2015 and April 2017. The primary outcome was lung function, measured by the peak expiratory flow rates (PEFRs) and forced expiratory volume in 1 second (FEV1). The secondary outcome was measured by the clinical assessment score. Furthermore, adverse events (AEs) were also recorded in this study. All outcomes were measured after 8-week treatment.After 8-week treatment, MCB showed greater effectiveness than did budesonide alone in improving the lung function, measured by PEFR V1 (P = .02), and FEV1 (P < .01). Similarly, the clinical assessment score also demonstrated significant difference between the 2 groups (P < .05). In addition, no serious AEs occurred in both groups.The results of this study demonstrate that the effectiveness of MCB is superior to budesonide alone in the treatment of children with CCVA.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wang XP,Yang LD,Zhou JF

doi

10.1097/MD.0000000000011557

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

e11557

issue

30

eissn

0025-7974

issn

1536-5964

pii

00005792-201807270-00033

journal_volume

97

pub_type

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