Abstract:
:Paraneoplastic neurological syndromes are very rare and often associated to breast, ovarian and small cells lung cancers. Paraneoplastic motor neuron diseases (MNDs) are even rarer, and frequently described in patients with breast cancer. We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor neuron disease. In literature, few cases are reported but no one highlights the tumor receptors' profile. Instead, HER2-positive breast cancers are prone to be related to anti-Yo-associated paraneoplastic cerebellar disorders. Anti-onconeural antibodies positivity can be rarely found, confirming that paraneoplastic MND have no specific biomarkers. The presence of CSF oligoclonal bands (OBs) suggests the presence of immune-mediated mechanism, in absence of other possible OBs causes.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Diamanti L,Quaquarini E,Berzero G,Bini P,Gastaldi M,Franciotta D,Alfonsi E,Ceroni M,Frascaroli M,Bernardo A,Marchioni Edoi
10.1016/j.clineuro.2018.06.038subject
Has Abstractpub_date
2018-09-01 00:00:00pages
141-142eissn
0303-8467issn
1872-6968pii
S0303-8467(18)30258-0journal_volume
172pub_type
杂志文章,评审abstract::A patient is presented, who developed a suprasellar tumour. Stereotactical biopsy of the tumour revealed the diagnosis of a dysgerminoma. Immunocytochemical examination of the CSF showed neoplastic cells staining for human chorionic gonadotropin and for alpha-fetoprotein. The authors stress the possibility to diagnose...
journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2016.01.003
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doi:10.1016/s0303-8467(02)00113-0
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更新日期:2008-02-01 00:00:00
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doi:10.1016/0303-8467(94)90117-1
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pub_type: 杂志文章,meta分析
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journal_title:Clinical neurology and neurosurgery
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