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Doxifluridine (5'-dFUrd) in patients with advanced colorectal carcinoma. A phase II study.

Abstract：

:Infusion of 5'-dFUrd (2.0-3.0 g/m2 over 1 h on days 1-5 every 3rd week) resulted in one partial response in 21 patients with advanced and progressing colorectal cancer. No patient had received chemotherapy before the 5'-dFUrd trial. Hematological and gastrointestinal toxicity were generally mild. In 4 patients peripheral neurotoxicity was diagnosed during treatment, whereas transient cerebellopathy was observed in one. Cardiac side effects (repeated angina pectoris following 5'-dFUrd infusion) led to discontinuation of treatment after two courses in one patient. It is concluded that 5'-dFUrd at the above doses is not superior to conventional 5-FU treatment in colorectal cancer. Neurological and cardiac side effects are rare but may be a problem in individual patients.

journal_name

Cancer Chemother Pharmacol

journal_title

Cancer chemotherapy and pharmacology

authors

Fosså SD,Dahl O,Hoel R,Heier M,Loeb M

doi

10.1007/BF00257528

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

161-3

issue

2

eissn

0344-5704

issn

1432-0843

journal_volume

15

pub_type

杂志文章

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