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New clinical implications of anti-myelin oligodendrocyte glycoprotein antibodies in children with CNS demyelinating diseases.

Abstract：

:Acquired demyelinating CNS syndromes include a broad spectrum of clinical phenotypes and different entities can overlap. Therefore, differential diagnosis is still challenging. A humoral immune reaction against myelin oligodendrocyte glycoprotein (MOG) is present in a subgroup of these patients, particularly in children. Anti-MOG antibodies indicate a non-multiple sclerosis disease course. Indeed, early publications have suggested that anti-MOG antibodies argue for a monophasic course; recently an association with a high risk for recurrent non-MS disease has been shown. According new data, antibody analysis was included in a diagnostic algorithm for the diagnosis of acquired demyelinating CNS syndromes in children. Here, recent data from the implementation of anti-MOG antibodies in daily clinical practice are reviewed.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Di Pauli F,Reindl M,Berger T

doi

10.1016/j.msard.2018.02.023

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

35-37

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(18)30076-2

journal_volume

22

pub_type

杂志文章,评审

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