Abstract:
:Mammalian carbonic anhydrases (CAs; EC 4.2.1.1) of which 16 isoforms are known, are involved in important physiological functions. Their inhibition is exploited pharmacologically for the treatment of many diseases (glaucoma, edema, epilepsy, obesity, hypoxic tumors, neuropathic pain, etc.) but the activators were less investigated till recently. A review on the CA activation is presented, with the activation mechanism, drug design approaches of activators and comparison of the various isoforms activation profiles being discussed. Some CAs, which are abundant in the brain, were recently demonstrated to be activatable by drug-like compounds, affording the possibility to design agents that enhance cognition, with potential therapeutic applications in aging and neurodegenerative diseases as well as tissue engineering.
journal_name
Future Med Chemjournal_title
Future medicinal chemistryauthors
Supuran CTdoi
10.4155/fmc-2017-0223subject
Has Abstractpub_date
2018-03-01 00:00:00pages
561-573issue
5eissn
1756-8919issn
1756-8927journal_volume
10pub_type
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