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Down for the count: The critical endpoint in ototoxicity remains the cytocochleogram.

Abstract：

:There are three major assays that must be conducted in standard investigational new drug (IND) -enabling ototoxicity study designs: 1) functional acoustic threshold measurements (Auditory Brainstem Respsonse, ABR); 2) otohistopathology and 3) cytocochleograms. We provide evidence to demonstrate the unreliability of auditory threshold shifts (ABRs) to predict cochlear cell death and build a case for conducting full cochlea processing and cell count measurements from the complete cochlea from apex to base.

journal_name

J Pharmacol Toxicol Methods

journal_title

Journal of pharmacological and toxicological methods

authors

Gauvin DV,Yoder J,Koch A,Zimmermann ZJ,Tapp RL

doi

10.1016/j.vascn.2017.09.254

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

123-129

issue

Pt 2

eissn

1056-8719

issn

1873-488X

pii

S1056-8719(17)30193-4

journal_volume

88

pub_type

杂志文章,评审

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