Abstract:
STUDY DESIGN:Animal experimental study. OBJECTIVE:Evaluate the effect of physical activity and overtraining condition on glycosaminoglycan concentration on the intervertebral disc (IVD) using a rat running model. SUMMARY OF BACKGROUND DATA:Some guidelines recommend the implementation of a physical exercise program as treatment for low back pain; however, cyclic loading impact on the health of the IVD and whether there is a dose-response relationship is still incompletely understood. METHODS:Thirty-two rats ages 8 weeks were divided into four groups with eight animals each. The first 8 weeks were the adaptive phase, the overtraining phase was from the ninth to the eleventh week, which consisted of increasing the number of daily training sessions from 1 to 4 and the recovery phase was represented by the 12th and 13th weeks without training. Control group 1 (CG1) did not undergo any kind of training. Control group 2 (CG2) completed just the adaptive phase. Overtraining group 1 (OT1) completed the overtraining phase. Overtraining group 2 (OT2) completed the recovery phase. Running performance tests were used to assess the "overtraining" status of the animals. IVD glycosaminoglycans were extracted and quantified, and identified by electrophoresis. RESULTS:Glycosaminoglycans showed a distribution between chondroitin sulfate and dermatan sulfate. Glycosaminoglycans quantification showed decreasing concentration at the following order: OT1 > CG2 > OT2 > CG1. Increased expression of dermatan sulfate was verified at the groups submitted to any training. CONCLUSION:Overtraining condition, as assessed by muscle and cardiovascular endurance did not lessen glycosaminoglycan concentration in the IVD. In fact, physical exercise increased glycosaminoglycan concentration in the IVD in proportion to the training load, even at overtraining condition, returning to normal levels after the recovery phase and glycosaminoglycan production is a reversible acute positive response for mechanical stimulation of the IVD. LEVEL OF EVIDENCE:N/A.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
Ueta RHS,Tarini VAF,Franciozi CES,Tamaoki MJS,Medeiros VP,Nader HB,Faloppa Fdoi
10.1097/BRS.0000000000002368subject
Has Abstractpub_date
2018-01-01 00:00:00pages
E1-E6issue
1eissn
0362-2436issn
1528-1159pii
00007632-201801010-00003journal_volume
43pub_type
杂志文章相关文献
SPINE文献大全abstract::Twelve patients with locked facets of the lower cervical spine were surgically treated through an anterior approach. The interlocking was bilateral in 2 cases and unilateral in 10; in all patients, skull traction failed to obtain the reduction. The technique of anterior reduction is described, with particular attentio...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197905000-00003
更新日期:1979-05-01 00:00:00
abstract:STUDY DESIGN:Randomized, controlled trial. OBJECTIVE:To evaluate a four-session self-management group intervention for patients with pain in primary care, led by trained lay persons with back pain. The intervention was designed to reduce patient worries, encourage self-care, and reduce activity limitations. BACKGROUN...
journal_title:Spine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00007632-199812010-00016
更新日期:1998-12-01 00:00:00
abstract:STUDY DESIGN:Case series and review of literature. OBJECTIVE:To report three cases of vascular injury during posterior lumbar disc surgery, two of these occurred during open discectomy, and one during an endoscopic surgery. Aim is to highlight importance of early diagnosis and prompt steps taken to prevent morbidity a...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0000000000003100
更新日期:2019-10-15 00:00:00
abstract:STUDY DESIGN:A retrospective study. OBJECTIVE:To investigate the treatment of odontoid fractures combined with lower cervical spinal injury. SUMMARY OF BACKGROUND DATA:Odontoid fractures combined with a lower cervical spinal injury are rarely reported in the literature and their incidence and characteristics are not ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817c4ecf
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:To assess the effects of acupuncture and dry-needling for the treatment of nonspecific low back pain. BACKGROUND:Low back pain is usually a self-limiting condition that tends to improve spontaneously over time. However, for many people, back pain becomes a chronic or recurrent problem for which a large vari...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/01.brs.0000158941.21571.01
更新日期:2005-04-15 00:00:00
abstract:STUDY DESIGN:Clinical trial (phase II). OBJECTIVES:To assess the feasibility and safety of balloon vertebroplasty after posterior short-segment reduction and fixation for the treatment of traumatic burst fractures. SUMMARY OF BACKGROUND DATA:Hardware failure and loss of reduction after posterior short-segment instrum...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000152162.64015.fb
更新日期:2005-02-01 00:00:00
abstract:STUDY DESIGN:A pre- and postintervention randomized, controlled trial was conducted. OBJECTIVE:To evaluate the effect of progressive resistance exercise training using a variable-angle Roman chair on the development of lumbar extensor endurance and strength. SUMMARY OF BACKGROUND DATA:Progressive resistance exercise ...
journal_title:Spine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00007632-200208150-00016
更新日期:2002-08-15 00:00:00
abstract::The aim of this study is to demonstrate an effective method of testing using the Sixteen Personality Factor Questionnaire (16 PF) along with the Minnesota Multiphasic Personality Inventory (MMPI) to predict outcome criteria in a spinal pain clinic. Using an objective system of criteria for patient achievement, includi...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198203000-00012
更新日期:1982-03-01 00:00:00
abstract:STUDY DESIGN:A rat tail model was used to test the hypothesis that angulation and asymmetric axial compressive loading would lead to vertebral wedging because of asymmetric longitudinal growth in the physes. OBJECTIVES:To study the effect of angulation and asymmetric loading on the progression of spinal curvature in a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199706150-00003
更新日期:1997-06-15 00:00:00
abstract:STUDY DESIGN:Prospective imaging study. OBJECTIVE:To clarify the frequency of positional vertebral artery (VA) occlusion using duplex ultrasonography in patients with rheumatoid arthritis (RA). SUMMARY OF BACKGROUND DATA:Some patients with upper cervical RA develop thromboembolic stroke related to positional and tran...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001136
更新日期:2016-01-01 00:00:00
abstract:STUDY DESIGN:Systematic review of randomized clinical trials. OBJECTIVES:To assess the efficacy of spinal manipulation for patients with low back pain. SUMMARY OF BACKGROUND DATA:The management of low back pain remains controversial. Spinal manipulation is a widely used treatment option for low back pain. Recently is...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/00007632-199612150-00013
更新日期:1996-12-15 00:00:00
abstract:STUDY DESIGN:A retrospective analysis of the clinical outcomes of eight patients with the lumbar pars interarticulars defects treated by direct repair with the aid of intraoperative O-arm based navigation and microendoscopic techniques. OBJECTIVE:The aim of this study was to investigate the efficacy and safety of dire...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001815
更新日期:2016-10-01 00:00:00
abstract:STUDY DESIGN:Case-control observational study. OBJECTIVE:Determination of dimensional changes in the lumbar spines of athletes between supine and stand-up position in MRI, concerning the lordosis, spinal canal cross-sectional area (SCCA), dural sac cross-sectional area (DSCA), sagittal dural sac diameter (SDSD), the l...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181bdb2d3
更新日期:2010-04-20 00:00:00
abstract:STUDY DESIGN:A retrospective cohort study. OBJECTIVE:To assess the ability of local vancomycin powder to prevent wound infection after posterior cervical fusion. SUMMARY OF BACKGROUND DATA:Wound infections are a significant source of morbidity and cost associated with spine surgery. Intraoperative application of vanc...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e318285b219
更新日期:2013-05-20 00:00:00
abstract:STUDY DESIGN:Clinical case report of bilateral stress fractures of the pedicle in a female athlete presenting with back pain. OBJECTIVES:To report this unusual case and surgical treatment and to review the relevant literature. SUMMARY OF BACKGROUND DATA:Low back pain is a frequent complaint in athletes, with the majo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000105988.43472.2B
更新日期:2004-01-15 00:00:00
abstract:STUDY DESIGN:Report of the use of one segmental artery from the left renal artery as inflow source for reconstructing a spine with recalcitrant osteomyelitis. OBJECTIVE:To describe one difficult case of spinal osteomyelitis and our reconstruction procedure. SUMMARY OF BACKGROUND DATA:The use of a vascularized fibular...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181ecbfa1
更新日期:2010-12-01 00:00:00
abstract::By measurement of intradiscal pressure in vitro, the hydrostatic properties of the nucleus pulposus of normal lumbar intervertebral disc were proven. The hydrodynamic properties seem to exist also in the somewhat degenerated disc, but not in the more severely deranged ones. Intravitally-performed measurements of disc ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198101000-00020
更新日期:1981-01-01 00:00:00
abstract:STUDY DESIGN:Multicenter case-control study. OBJECTIVE:To investigate the prevalence of back problems in adults with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA:Information on the prevalence of back problems in adults with idiopathic scoliosis is scarce, especially in untreated individuals, males, and individual...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000312
更新日期:2014-05-15 00:00:00
abstract:STUDY DESIGN:A retrospective multicenter study. OBJECTIVE:To identify risk factors for postoperative complications associated with growing-rod (GR) surgery for early-onset scoliosis (EOS). SUMMARY OF BACKGROUND DATA:Results and complications of GR surgery for EOS have not been adequately studied. METHODS:We evaluate...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e318288671a
更新日期:2013-04-15 00:00:00
abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To compare outcomes and complication rates between patients with and without Parkinson's disease (PD) patients undergoing surgery for adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA:There is limited literature evaluating the impact of PD on long-term outcomes af...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002998
更新日期:2019-07-15 00:00:00
abstract::Twenty-two patients with continued, undiagnosed symptoms of low back and sciatic pain for an average of 14 months were assessed. Patients studied had prior negative evaluations, including EMG, CT scanning, and/or metrizamide myelography. Three-level, posterolateral, extradural discography was performed on the side opp...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198604000-00013
更新日期:1986-04-01 00:00:00
abstract:STUDY DESIGN:Measurement of the kinematics of the lumbar spine after insertion of an interspinous spacer in vitro. OBJECTIVES:To understand the kinematics of the instrumented and adjacent levels due to the insertion of this interspinous implant. SUMMARY OF BACKGROUND DATA:An interspinous spacer (X Stop, SFMT, Concord...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.BRS.0000084877.88192.8E
更新日期:2003-10-01 00:00:00
abstract:STUDY DESIGN:Linear and angular measurements were performed on 128 vertebrae (16 spines) from C5 to T5. OBJECTIVES:Vertebrae were studied to characterize vertebral shape and size changes in the cervico-thoracic region. SUMMARY OF BACKGROUND DATA:Analysis of vertebral anatomy has been extensive and well characterized....
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199409150-00014
更新日期:1994-09-15 00:00:00
abstract:STUDY DESIGN:Prospective multicenter observation. OBJECTIVE:To determine the validity of 3 commercially available at recording thoracic-lumbar-sacral orthosis (TLSO) wearing time of children with spinal cord injury (SCI) and to assess each monitor's function during daily activities. SUMMARY OF BACKGROUND DATA:A major...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0b013e318178864e
更新日期:2008-06-15 00:00:00
abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To identify the incidence and characteristics of rib anomalies in patients with congenital scoliosis (CS) in a Chinese population. SUMMARY OF BACKGROUND DATA:Rib deformities and intraspinal anomalies often coexist in individuals with CS. Rib deformities may assist in diagn...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000000008
更新日期:2013-12-15 00:00:00
abstract:STUDY DESIGN:The authors prospectively evaluated 40 patients with paralytic scoliosis treated from 1985 to 1990 with bilateral posterior segmental instrumentation, facet fusions, local bone graft, and allograft (mostly fresh frozen) bone supplementation only. OBJECTIVES:The authors report the fusion results for these ...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:STUDY DESIGN:Mixed-method. OBJECTIVE:To evaluate the association between objective and subjective cervical range of motion (ROM) among patients with neck pain, and to assess the awareness of impairments. SUMMARY OF BACKGROUND DATA:Cervical ROM is frequently used to evaluate neck pain, but it is also important to know...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002627
更新日期:2018-09-15 00:00:00
abstract:STUDY DESIGN:Immunohistological and behavioral analysis of the effect of a tumor necrosis factor alpha (TNF-alpha) inhibitor in an injured-nerve model. OBJECTIVE:To examine the effect of direct application of a TNF-alpha inhibitor (etanercept) on injured-nerve pain caused by nucleus pulposus. SUMMARY AND BACKGROUND D...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31818441a2
更新日期:2008-10-15 00:00:00
abstract:STUDY DESIGN:The shape and orientation of the thoracic and lumbar zygapophyseal facets at the T1-L5 level in children were measured and analyzed. OBJECTIVE:To detect the pattern of zygapophyseal facet asymmetry in the thoracic and lumbar spines in children. SUMMARY OF BACKGROUND DATA:Whereas many studies have defined...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31816b1f83
更新日期:2008-04-15 00:00:00
abstract:STUDY DESIGN:Retrospective review of prospectively-collected, multicenter adult spinal deformity (ASD) database. OBJECTIVE:The aim of this study was to evaluate the rate of patients who accrue catastrophic cost (CC) with ASD surgery utilizing direct, actual costs, and determine the feasibility of predicting these outl...
journal_title:Spine
pub_type: 杂志文章,多中心研究
doi:10.1097/BRS.0000000000003242
更新日期:2020-03-01 00:00:00