Abstract:
:Platinum resistance is a critical barrier for clinicians to improve the survival of ovarian cancer. Our study evaluated the correlation between copy number variations (CNVs) of neurotrophic tyrosine receptor kinase 3 (NTRK3) and the prognosis of ovarian cancer, which might predict platinum resistance in ovarian cancer patients.Array comparative genomic hybridization (CGH) was used to test gene backgrounds between platinum-sensitive and platinum-resistant relapsed populations and CNVs of NTRK3 were indicated by cluster analysis. Fluorescence in situ hybridization (FISH) was adopted in 41 cases for further verification, which confirmed the results of array CGH. Spearman's rank correlation analysis and χ test were used to evaluate the accuracy of CNVs of NTRK3 which predicted platinum-sensitive or platinum-resistant recurrence.We detected CNVs of NTRK3 between 2 groups by array CGH, and amplification of NTRK3 was confirmed by FISH in the platinum-sensitive recurrence group with enlarged samples. The test concordance of 2 methods was 78.6%. Among 41 cases with satisfied FISH results, the median time to recurrence (TTR) of patients with amplified and nonamplified NTRK3 were respectively 18 and 5 months (P <.01). The cut-off value of TTR to differentiate platinum-sensitive or platinum-resistant recurrence was 6 months in accordance with clinical practice. According to the above standard, 15 cases with NTRK3 amplification were platinum-sensitive and 12 cases without NTRK3 amplification were platinum-resistant recurrences which demonstrated that the accuracy of NTRK3 amplification/nonamplification to predict recurrent types was 65.9% (27/41).CNVs of NTRK3 were associated with platinum-sensitive and platinum-resistant recurrences. Amplification of NTRK3 perfectly predicted platinum-sensitive relapse of ovarian cancer.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Ge L,Li N,Liu M,Xu NZ,Wang MR,Wu LYdoi
10.1097/MD.0000000000007621subject
Has Abstractpub_date
2017-07-01 00:00:00pages
e7621issue
30eissn
0025-7974issn
1536-5964pii
00005792-201707280-00051journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are immune therapies that have shown great promise in the treatment of multiple cancers. However, immune-related adverse events of PD-1 and PD-L1 inhibitors may limit their use in non-small cell lung cancer (NSCLC). Given the rising n...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021613
更新日期:2020-08-07 00:00:00
abstract::Transient receptor potential vanilloid-1 (TRPV1) receptor and proteinase-activated receptor 2 (PAR2) have been implicated in the mechanism of acid-induced inflammation in gastroesophageal reflux disease (GERD). We aimed to evaluate TRPV1 and PAR2 mRNA expression levels in the GERD patients and their relationship with ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004387
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Lead is a toxic element of the environment which leads to major complications once it enters the blood stream, affecting multiple organs and systems of the body. METHODS:We present the case of a 16-year-old girl, diagnosed with lead poisoning after occupational exposure due to the fact that the girl was act...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000004916
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Testicular capillary hemangioma (TCH) is a rare benign tumor of the testis. To the authors' knowledge, there is currently only a few literatures describing the use of contrast-enhanced ultrasound (CEUS) to diagnose TCH. Accurate preoperative diagnosis of benign tumors can avoid orchiectomy. A case of TCH eval...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014779
更新日期:2019-03-01 00:00:00
abstract::Aortoiliac occlusive disease (AIOD) affects the systemic vascular resistance and increases the afterload because the left ventricle (LV) must work harder to eject blood into a smaller vascular bed. This study was to determine whether successful revascularization of AIOD is associated with improvement of left ventricul...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012339
更新日期:2018-09-01 00:00:00
abstract::To compare results for radiological prediction of pathological invasiveness in lung adenocarcinoma between radiologists and a deep learning (DL) system.Ninety patients (50 men, 40 women; mean age, 66 years; range, 40-88 years) who underwent pre-operative chest computed tomography (CT) with 0.625-mm slice thickness wer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016119
更新日期:2019-06-01 00:00:00
abstract::The aim of this study was to investigate the correlation between cluster of differentiation 86 (CD86) gene rs1129055 and rs2715267 single nucleotide polymorphisms and sepsis susceptibility.One hundred twenty-five sepsis patients and 120 healthy controls were enrolled in this case-control study. CD86 polymorphisms rs11...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017482
更新日期:2019-10-01 00:00:00
abstract::Chronic postsurgical pain (CPSP) is an important clinic problem. It is assessed that prevalence of chronic pain extends to 30% but it is contended that there are various risk factors. We aimed to evaluate the prevalence of chronic pain after hysterectomy, risk factors of chronicity, neuropathic features of pain, and s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004484
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVES:To conduct a meta-analysis of studies comparing the renoprotective effects of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACEI/ARB) combined with either calcium channel blocker (CCB) or diuretic, but not both, in hypertensive patients. DATA SOURCES:Pubmed, Embase, Medline, and Coch...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000004167
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Bee venom acupuncture has been used in treating patients with shoulder adhesive capsulitis, yet the effectiveness and safety remains unclear. Therefore, this systematic review will aim to assess the effectiveness and safety of bee venom acupuncture for shoulder adhesive capsulitis. METHODS:Electronic databa...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019975
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) refers to head injuries that disrupt normal function of the brain. TBI commonly lead to a wide range of potential psychosocial functional deficits. Although psychosocial function after TBI is influenced by many factors, more and more evidence shows that social cognitive skills ar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021154
更新日期:2020-07-17 00:00:00
abstract::To compare the clinical outcome of digital and manual marking for toric intraocular lens (IOL) alignment. This is a prospective clinical study that included 60 eyes of 60 patients undergoing cataract surgery with coexisting corneal astigmatism more than 1 diopter (D). The eyes were randomly assigned to either digital ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000001618
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:This protocol for a systematic review describes the methods that will be used to evaluate the efficacy and safety of non-pharmacological interventions for patients with dementia. METHODS:We will search ALOIS, the specialized register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG), without ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017279
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:To evaluate the safety and efficacy of dexmedetomidine in patients undergoing total knee and hip arthroplasty for postoperative pain control. METHODS:An updated systematic review and meta-analysis of randomized controlled trials (RCTs) identified in systematic searches of MEDLINE, EMBASE, Google Scholar, th...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018538
更新日期:2020-01-01 00:00:00
abstract::To establish a clinical prediction rule for acute bilirubin encephalopathy (ABE) in term/near-term neonates with extreme hyperbilirubinemia.A retrospective cohort study was conducted between January 2015 and December 2018. Six hundred seventy-three out of 26,369 consecutive neonates with extreme hyperbilirubinemia wer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019364
更新日期:2020-02-01 00:00:00
abstract::Cirrhosis and idiopathic portal hypertension (IPH) are 2 major diseases showing portal hypertension. However, characteristics and outcomes of IPH with ascites have not yet been determined. The aim of the study was to examine the influence of ascites on the long-term clinical course of IPH.This observational study comp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001056
更新日期:2015-07-01 00:00:00
abstract:RATIONALE:Immunoglobulin G4-related disease (IgG4-RD) is regarded as an immune-mediated systemic fibroinflammatory disease. Several studies have linked IgG4-RD to infections such as tuberculosis and actinomycosis. However, the coexistence of IgG4-RD and non-tuberculous mycobacterium (NTM) in a single pulmonary nodule h...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018179
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The prognostic significance of phosphatase and tensin homolog (PTEN) in patients with breast cancer (BC) remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer. METHODS:PubMed, EMBASE, ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000008000
更新日期:2017-09-01 00:00:00
abstract:RATIONALE:We report on a patient with injury of the cortico-ponto-cerebellar tract (CPCT) following mild traumatic brain injury (TBI), diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS:A 53-year-old female patient was injured in a car crash. While under treatment at a local medical center for headache...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008749
更新日期:2017-12-01 00:00:00
abstract::Since the progression of cirrhosis is accelerated each time a complication recurs, the management and treatment of the complication is critical in enhancement of the quality of life and expectation of life in patients. The use of model for end-stage liver disease with incorporation of serum-sodium (MELD-Na) with physi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017862
更新日期:2019-11-01 00:00:00
abstract::Although supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic require...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000001726
更新日期:2015-10-01 00:00:00
abstract:RATIONALE:Tibial hemimelia is known as a rare congenital lower limb deficiency. It has been classified into different types based on Jones classification, and the traditional treatment of tibial hemimelia is amputation. Here we present a variant and unclassified case of tibial hemimelia, which was caused by osteomyelit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014031
更新日期:2019-01-01 00:00:00
abstract::To our knowledge, the association between antidepressant exposure and endometrial cancer has not been previously explored. Herein, we aim to investigate the association between antidepressant prescription, including novel antidepressants, and the risk for endometrial cancer in a population-based study.Data for the ana...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004178
更新日期:2016-07-01 00:00:00
abstract::Luminal A breast cancer has a much better prognosis than other subtypes, with a low risk of local or regional recurrence. However, there is controversy around under- versus overtreatment with regard to adjuvant treatment of node-positive, luminal A breast cancer. The purpose of this study was to identify whether adjuv...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006777
更新日期:2017-06-01 00:00:00
abstract::Nocardia is a ubiquitous environmental pathogen that causes infection primarily following inhalation into the lungs. It is generally thought to cause infection primarily in immunocompromised patients, but nonimmunocompromised individuals are also at risk of infection. We sought to compare risk factors, clinical manife...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012436
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Metastatic cardiac tumor (MCT) is rare in clinical practice. MCT presenting initially as atrial fibrillation (AF) is even rarer. PATIENT CONCERNS:We report a 47-year-old woman with no previous medical history presented with intermittent palpitation for 3 days. DIAGNOSES:The electrocardiography showed AF wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007649
更新日期:2017-08-01 00:00:00
abstract:RATIONALE:The significant ultrasonic characteristics of amniotic band syndrome (ABS) are the malformations of fetal affected parts and the band-like echoes in amniotic cavity. This article first suggests that the fetal hand adhered to umbilical cord with restricted movement provides some values in the diagnosis of ABS ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018302
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated that coronary microcirculation dysfunction (CMVD) is closely correlated with adverse clinical outcomes. In this study, quantitative stress myocardial contrast echocardiography (MCE) was used to evaluate the CMVD and to investigate its association with the prognosis of patient...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000015990
更新日期:2019-07-01 00:00:00
abstract::Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007532
更新日期:2017-08-01 00:00:00
abstract:RATIONALE:Primary repair of acute ligament injury is possible due to the proximity of the ends. In the case of chronic injury, however, primary repair is difficult because the ends of ruptured ligament will have receded, and tendon graft, transfer, or reconstruction is needed. Satisfactory clinical results have been re...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022506
更新日期:2020-10-02 00:00:00