Abstract：
:While the adoption of next generation sequencing has rapidly expanded, the informatics infrastructure used to manage the data generated by this technology has not kept pace. Historically, relational databases have provided much of the framework for data storage and retrieval. Newer technologies based on NoSQL architectures may provide significant advantages in storage and query efficiency, thereby reducing the cost of data management. But their relative advantage when applied to biomedical data sets, such as genetic data, has not been characterized. To this end, we compared the storage, indexing, and query efficiency of a common relational database (MySQL), a document-oriented NoSQL database (MongoDB), and a relational database with NoSQL support (PostgreSQL). When used to store genomic annotations from the dbSNP database, we found the NoSQL architectures to outperform traditional, relational models for speed of data storage, indexing, and query retrieval in nearly every operation. These findings strongly support the use of novel database technologies to improve the efficiency of data management within the biological sciences.
journal_name
J Biomed Informjournal_title
Journal of biomedical informaticsauthors
Schulz WL,Nelson BG,Felker DK,Durant TJS,Torres Rdoi
10.1016/j.jbi.2016.10.015subject
Has Abstractpub_date
2016-12-01 00:00:00pages
288-295eissn
1532-0464issn
1532-0480pii
S1532-0464(16)30152-6journal_volume
64pub_type
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