Abstract:
AIM OF THE STUDY:Neonatal encephalopathy (NE) of hypoxic-ischaemic origin may cause death or life-long disability which is reduced by therapeutic hypothermia (TH). Our objective was to assess HR response in infants undergoing TH after perinatal asphyxia. METHODS:We performed a retrospective case series, from a single-centre tertiary care NICU. We included ninety-two infants with NE of likely hypoxic-ischaemic origin, moderate or severe, treated with TH (n=60) or normothermia (n=32) who had 18 month outcome data and at least 12 HR recordings the first 24h after birth (1998-2010) Bristol, UK. Poor outcome was defined as death or severe disability. Data are reported as medians and 95% confidence intervals (CI). RESULTS:TH to 33.5°C decreased HR by 30bpm to 92bpm (95% CI: 88, 96) 12h after birth in infants with NE and good outcome as compared to infants treated at normothermia 118bpm (95% CI: 110, 130). Despite constant low rectal temperature, HR increased gradually during cooling from 36 to 72h to 97bpm (89, 106) approaching the normothermia group, 117bpm (96, 133). During TH, infants with poor outcome had higher HR at 12h after birth (112bpm, 95% CI: 92, 115) as compared to infants with good outcome (p=0.004). Inotropic support increased HR by 17bpm in infants with good outcome and by 22bpm in infants with poor outcome. CONCLUSIONS:In NE, TH decreases HR the first day of life. HR remained lower during TH, but increased during the last day of TH. Infants with poor outcome have higher HR.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Elstad M,Liu X,Thoresen Mdoi
10.1016/j.resuscitation.2016.06.023subject
Has Abstractpub_date
2016-09-01 00:00:00pages
53-7eissn
0300-9572issn
1873-1570pii
S0300-9572(16)30121-6journal_volume
106pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract::Apneic asphyxia to cardiac arrest (CA) in rats of 10 min was reversed by cardiopulmonary resuscitation (CPR), and after controlled ventilation and controlled normotension for 20 min, was followed by decapitation and brain freezing, and determination of brain concentrations of cytosolic and lysosomal enzymes. Normal va...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(89)90078-6
更新日期:1989-02-01 00:00:00
abstract:AIM OF THE STUDY:The role of supralaryngeal devices in airway management in out-of-hospital cardiac arrests (OHCA) remains controversial. The aim of this prospective observational trial was to evaluate the feasibility and effectiveness of intubating laryngeal mask airway (ILMA) when used by trained prehospital emergenc...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2013.11.006
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Current resuscitation guidelines endorse placing the unconscious and normally breathing victims in the recovery position (RP), but this technique might hinder breathing evaluation. AIM:To compare breathing evaluation and cardiac arrest detection: placing the victim in RP and checking breathing regularly, pl...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2018.10.030
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Recent cardio pulmonary resuscitation (CPR) guidelines changed the compression:ventilation ratio in 30:2. OBJECTIVE:To compare the quality of chest compressions and exhaustion using the ratio 30:2 versus 15:2. METHODS:A prospective, randomised crossover design was used. Subjects were recruited from the H.-...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2006.12.004
更新日期:2007-07-01 00:00:00
abstract:STUDY OBJECTIVE:For trials involving exception from informed consent, some IRBs require that community members be allowed to "opt out" prior to enrollment. We tested for geospatial clustering of opt-out requests and the associated census tract characteristics in one study region. METHODS:This was a retrospective study...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2008.10.003
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To demonstrate that intraosseous infusions via the calcaneus could deliver fluids to systemic veins and that intraosseous infusions do not require bones with medullary cavities. To demonstrate that intraosseous infusions could be successful in adults. DESIGN:Ten adult cadavers were injected with 16 gauge in...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2004.02.012
更新日期:2004-07-01 00:00:00
abstract:AIM:The quality of cardiopulmonary resuscitation (CPR) is associated with the rate of return of spontaneous circulation (ROSC) during human cardiac arrest. Current advances in defibrillator technology enable measurement of CPR quality during resuscitation, but it is not known whether this is directly reflected in cereb...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2011.09.011
更新日期:2012-01-01 00:00:00
abstract::Mild to moderate hypothermia has been employed since the 1940s in the treatment of acute blunt head trauma. The utility of hypothermia in ischemic injury has been confirmed, by both animal studies and clinical experience, in cardiovascular and neurological surgery. In blunt injury, though, only one prospective, random...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/0300-9572(94)90049-3
更新日期:1994-07-01 00:00:00
abstract:PURPOSE:Airway management for successful ventilation by laypersons and inexperienced healthcare providers is difficult to achieve. Bag-valve mask (BVM) ventilation requires extensive training and is performed poorly. Supraglottic airway devices (SADs) have been successfully introduced to clinical resuscitation practice...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2010.11.014
更新日期:2011-03-01 00:00:00
abstract:AIM OF THE STUDY:We investigated implementation and efficacy of mild therapeutic hypothermia in the treatment of out-of-hospital cardiac arrest due to ventricular fibrillation. MATERIALS AND METHODS:Two periods were compared, an historical one (36 patients) between 2000 and 2002 where therapeutic hypothermia was never...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2007.04.014
更新日期:2007-11-01 00:00:00
abstract:AIM:Cardiopulmonary resuscitation (CPR) guidelines recommend specific chest compression (CC) target depths for children. We quantitatively describe relative anterior-posterior diameter (APD) depth, actual depth, and force of CCs during real CPR events in children. METHODS:CC depth and force were recorded during real C...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2011.10.014
更新日期:2012-03-01 00:00:00
abstract::Visceral organs display differential sensitivity to ischemia and reperfusion injury, but the cellular mechanisms underlying these differential responses are not completely understood. A significant response to ischemia identified in brain is stress to the endoplasmic reticulum (ER), as indicated by PKR-like endoplasmi...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.03.014
更新日期:2005-09-01 00:00:00
abstract::Although often preventable, drowning remains a leading cause of accidental death, especially in children. New definitions classify drowning as the process of experiencing respiratory impairment from submersion or immersion in a liquid. The key pathophysiological feature in drowning is hypoxia. Accurate neurological pr...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/j.resuscitation.2004.06.007
更新日期:2004-12-01 00:00:00
abstract::One of the pioneers of open chest cardiac massage was Cemil Topuzlu Pasha, in Turkey. He presented his experience in open heart cardiac massage in several papers published in Ottoman and French and German. On 27 August 1903 one of his patients undergoing external urethrotomy under chloroform anaesthesia developed card...
journal_title:Resuscitation
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.resuscitation.2005.07.001
更新日期:2006-02-01 00:00:00
abstract::We evaluated the ability of a previously derived outcome predictor to discriminate between ECG segments corresponding to return of spontaneous circulation (ROSC) or not in validation data from 136 patients with cardiac arrest. The new data used for validation were totally independent from the predictor derivation data...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.05.006
更新日期:2005-10-01 00:00:00
abstract:CONTEXT:Extracorporeal cardiopulmonary resuscitation (ECPR) refers to emergent percutaneous veno-arterial cardiopulmonary bypass to stabilize and provide temporary support of patients who suffer cardiopulmonary arrest. Initiation of ECPR by emergency physicians with meaningful long-term patient survival has not been de...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.01.027
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:The number of chest compressions required for optimal generation of coronary perfusion pressure remains unknown although studies examining compression-to-ventilation ratios higher than 15:2 (C:V) in animals have reported higher C:V to be superior for return of spontaneous circulation and neurologic outcome. ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2004.11.026
更新日期:2005-06-01 00:00:00
abstract:AIM:The aim of this study was to describe patient characteristics, event characteristics, and outcomes for patients with in-hospital cardiac arrest in Denmark. METHODS:Data was obtained from DANARREST. DANARREST is a nationwide registry that covers all in-hospital cardiac arrests in Denmark with a clinical indication ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.04.046
更新日期:2019-07-01 00:00:00
abstract::Active compression decompression resuscitation (ACD-CPR) has been developed as an alternative to standard cardiopulmonary resuscitation (S-CPR). To determine the effect of ACD-CPR on survival and neurologic outcome in patients with out-of-hospital cardiac arrest, this combined analysis involved individual patient data...
journal_title:Resuscitation
pub_type: 杂志文章,meta分析
doi:10.1016/s0300-9572(99)00073-8
更新日期:1999-08-01 00:00:00
abstract:AIM:To investigate the impact of a history of diabetes mellitus on the neurologic outcome in comatose survivors of cardiac arrest of cardiac origin treated with mild hypothermia. METHODS:A prospective observational study was performed between September 2003 and July 2008. Eighty comatose survivors of cardiac arrest of...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2009.04.041
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND AIM:Unsuccessful defibrillation shocks adversely affect survival from out-of-hospital cardiac arrest (OHCA). Ventricular fibrillation (VF) waveform analysis is the tool-of-choice for the non-invasive prediction of shock success, but surrogate markers of perfusion like end-tidal CO2 (EtCO2) could improve ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.02.028
更新日期:2019-05-01 00:00:00
abstract::Cardiac ischemia can present as distinctive clinical syndromes such as acute myocardial infarction, cardiogenic shock, sudden cardiac arrest or chronic congestive heart failure. All of the clinical syndromes share common pathophysiological events including reduction of cardiac output and systemic oxygen delivery (DO2)...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/0300-9572(94)90065-5
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:Despite its prevalence, survival from out-of-hospital cardiac arrest remains low. High quality CPR has been associated with improved survival in cardiac arrest patients. In early 2014, a program was initiated to provide feedback on CPR quality to prehospital providers after every treated cardiac arrest. OBJ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2017.02.004
更新日期:2017-04-01 00:00:00
abstract:AIM OF STUDY:High-quality CPR is associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). The purpose of this investigation was to compare the quality of CPR provided at the prehospital scene, during ambulance transport, and during the early minutes in the emergency department (ED). METHODS:A pros...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.07.042
更新日期:2013-05-01 00:00:00
abstract::The mechanism for the hemorrhage-induced drop in body temperature is unknown. This study determined the alterations in cutaneous heat exchange and metabolic heat production caused by a moderate hemorrhage in conscious rats. Chronically instrumented rats were subjected to a 16 ml/kg hemorrhage, followed by a 4-h recove...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(99)00169-0
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Postresuscitation myocardial dysfunction (PRMD) can develop after successful resuscitation from cardiac arrest. However, echocardiographic patterns of PRMD remain unknown. This study aimed to investigate PRMD manifestations with serial echocardiography during the post-cardiac arrest period. METHODS:We enrol...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.01.019
更新日期:2018-03-01 00:00:00
abstract::Many critically ill patients suffer pain which can produce by itself undesirable effects. Consequently, pain must be carefully prevented, or at least, treated early and effectively. Basal analgesia can be provided by repeated intramuscular administration of narcotics, or rather by continuous intravenous infusion of mo...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/0300-9572(84)90013-3
更新日期:1984-03-01 00:00:00
abstract::This randomized controlled trial was designed to evaluate the effects of simulated emergency medical service (EMS) transport related stress on hemodynamic variables, and catecholamine plasma levels. A total of 32 healthy male volunteers were randomized to being carried by paramedics from a third-floor apartment throug...
journal_title:Resuscitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0300-9572(00)00354-3
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVE:To determine if arterial oxygen and carbon dioxide abnormalities in the first 24h after return of spontaneous circulation (ROSC) are associated with increased mortality in adult out-of-hospital cardiac arrest (OHCA). METHODS:We used data from the Resuscitation Outcomes Consortium (ROC), including adult OHCA ...
journal_title:Resuscitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.resuscitation.2017.08.244
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Mathematical optimisation models have recently been applied to identify ideal Automatic External Defibrillator (AED) locations that maximise coverage of Out of Hospital Cardiac Arrest (OHCA). However, these fixed location models cannot relocate existing AEDs in a flexible way, and have nearly exclusively bee...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.01.055
更新日期:2018-04-01 00:00:00