Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner.

abstract：:Prenatal development and early childhood are critical periods for establishing the tissue-specific epigenome, and may have a profound impact on health and disease in later life. However, epigenomic profiles at birth and in early childhood remain largely unexplored. The focus of this report is to examine the individual...

journal_title：Epigenetics

authors： Wang D,Liu X,Zhou Y,Xie H,Hong X,Tsai HJ,Wang G,Liu R,Wang X

更新日期：2012-06-01 00:00:00

abstract：:Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC). In the present study, we performed high-throughput sequencing to determine the m6A methylome in CRC. ...

journal_title：Epigenetics

authors： Zhang Z,Wang Q,Zhang M,Zhang W,Zhao L,Yang C,Wang B,Jiang K,Ye Y,Shen Z,Wang S

更新日期：2020-08-12 00:00:00

abstract：:TAL1/SCL (hereafter referred to as TAL1) is a critical transcription factor required for hematopoiesis in which hematopoietic stem cells commit and differentiate to different lineages. During this process, transcription of many genes is turned on and off in part by epigenetic mechanisms. TAL1 has recently been shown t...

journal_title：Epigenetics

authors： Hu X,Ybarra R,Qiu Y,Bungert J,Huang S

更新日期：2009-08-16 00:00:00

abstract：:The dysregulation of genes in neurodevelopmental disorders that lead to social and cognitive phenotypes is a complex, multilayered process involving both genetics and epigenetics. Parent-of-origin effects of deletion and duplication of the 15q11-q13 locus leading to Angelman, Prader-Willi, and Dup15q syndromes are due...

journal_title：Epigenetics

authors： Lopez SJ,Dunaway K,Islam MS,Mordaunt C,Vogel Ciernia A,Meguro-Horike M,Horike SI,Segal DJ,LaSalle JM

更新日期：2017-01-01 00:00:00

abstract：:The methylation-free CpG island encompassing the divergently transcribed promoters of the HNRPA2B1 and CBX3 housekeeping genes possesses a dominant ubiquitously-acting chromatin opening element (UCOE) capability. This element allows reproducible and stable transgene expression including from within centromeric heteroc...

journal_title：Epigenetics

authors： Lindahl Allen M,Antoniou M

更新日期：2007-10-01 00:00:00

abstract：:Epigenetic modifications, such as DNA methylation, can be regulated by nutrition and dietary factors. There has been a large increase in the use of sustainable plant-based protein sources in fish feed due to limitations of fishmeal resources, which are needed to sustain a rapidly growing aquaculture industry. With thi...

journal_title：Epigenetics

authors： Dhanasiri A,Chen X,Dahle D,Siriyappagouder P,Fæste CK,Fernandes JMO

更新日期：2020-10-01 00:00:00

abstract：:In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their r...

journal_title：Epigenetics

authors： Lahmy S,Bies-Etheve N,Lagrange T

更新日期：2010-01-01 00:00:00

abstract：:As evidence for the existence of brain-expressed imprinted genes accumulates, we need to address exactly what they are doing in this tissue, especially in terms of organizational themes and the major challenges posed by reconciling imprinted gene action in brain with current evolutionary theories attempting to explain...

journal_title：Epigenetics

authors： Davies W,Isles AR,Humby T,Wilkinson LS

更新日期：2007-10-01 00:00:00

abstract：:The epigenetic alteration of aberrant hypermethylation in the promoter CpG island of a gene is associated with repression of transcription. In neoplastic cells, aberrant hypermethylation is well described as a mechanism of allele inactivation of particular genes with a tumor suppressor function. To investigate the rol...

journal_title：Epigenetics

authors： Ibragimova I,Dulaimi E,Slifker MJ,Chen DY,Uzzo RG,Cairns P

更新日期：2014-05-01 00:00:00

abstract：:Through epigenetic modifications, specific long-term phenotypic consequences can arise from environmental influence on slowly evolving genomic DNA. Heritable epigenetic information regulates nucleosomal arrangement around DNA and determines patterns of gene silencing or active transcription. One of the greatest challe...

journal_title：Epigenetics

authors： Mazzio EA,Soliman KF

更新日期：2012-02-01 00:00:00

abstract：:Great efforts in the field of solid organ transplantation are being devoted to identifying biomarkers that allow a transplanted patient's immune status to be established. Recently, it has been well documented that epigenetic mechanisms like DNA methylation and histone modifications regulate the expression of immune sy...

journal_title：Epigenetics

authors： Suárez-Álvarez B,Baragaño Raneros A,Ortega F,López-Larrea C

更新日期：2013-07-01 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder that can be prenatally suspected or diagnosed based on established clinical guidelines. Molecular confirmation is commonly performed on amniocytes. The possibility to use fresh (CVF) and cultured (CVC) chorionic villi has never been investigated. To verify wh...

journal_title：Epigenetics

authors： Paganini L,Carlessi N,Fontana L,Silipigni R,Motta S,Fiori S,Guerneri S,Lalatta F,Cereda A,Sirchia S,Miozzo M,Tabano S

更新日期：2015-01-01 00:00:00

abstract：:In this work we demonstrate a novel method of methylation detection that utilises immunoaffinity to detect the presence of methylated DNA hybridised to a cDNA microarray. We use a monoclonal antibody specific to 5 methyl cytidine to detect the presence of 5 methyl cytosine in genomic DNA from human fibroblasts bearing...

journal_title：Epigenetics

authors： Kelkar A,Deobagkar D

更新日期：2009-08-16 00:00:00

abstract：:Histone posttranslational modifications control the organization and function of chromatin. In particular, methylation of lysine 36 in histone H3 (H3K36me) has been shown to mediate gene transcription, DNA repair, cell cycle regulation, and pre-mRNA splicing. Notably, mutations at or near this residue have been causal...

journal_title：Epigenetics

authors： Klein BJ,Krajewski K,Restrepo S,Lewis PW,Strahl BD,Kutateladze TG

更新日期：2018-01-01 00:00:00

abstract：:Recently a mouse model of T/natural killer acute lymphoblastic leukemia was used to assess global promoter methylation across the mouse genome using the restriction landmark genomic scanning technique. One of the methylated mouse genes identified in this way was Slit2. There are three mammalian SLIT genes (SLIT1, SLIT...

journal_title：Epigenetics

authors： Dunwell TL,Dickinson RE,Stankovic T,Dallol A,Weston V,Austen B,Catchpoole D,Maher ER,Latif F

更新日期：2009-05-16 00:00:00

abstract：:DNA methylation regulates gene expression in a cell-type specific way. Although peripheral blood mononuclear cells (PBMCs) comprise a heterogeneous cell population, most studies of DNA methylation in blood are performed on total mononuclear cells. In this study, we investigated high resolution methylation profiles of ...

journal_title：Epigenetics

authors： Jacoby M,Gohrbandt S,Clausse V,Brons NH,Muller CP

更新日期：2012-12-01 00:00:00

abstract：:Post translational modification (PTM) of histones has long been associated with epigenetic regulation. Although genomic approaches have established correlation between a handful of histone PTMs and transcriptional states, only recently have advancements in proteomics provided the tools necessary to study histone prote...

journal_title：Epigenetics

authors： Brumbaugh J,Phanstiel D,Coon JJ

更新日期：2008-09-01 00:00:00

abstract：:This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers. The original method includes chromosome 3 specific NotI-microarrays containing 180 NotI clones associated with genes for hybridization with 40 paired norma...

journal_title：Epigenetics

authors： Dmitriev AA,Kashuba VI,Haraldson K,Senchenko VN,Pavlova TV,Kudryavtseva AV,Anedchenko EA,Krasnov GS,Pronina IV,Loginov VI,Kondratieva TT,Kazubskaya TP,Braga EA,Yenamandra SP,Ignatjev I,Ernberg I,Klein G,Lerman MI,Zaba

更新日期：2012-05-01 00:00:00

abstract：:Interindividual variability of DNA methylation is a mechanism of the epigenetic drift in aging. Studies on cross-sectional data have discovered a change in methylation variability in association with age. However, thus far, no method explored DNA methylation variability in longitudinal data, which was the aim of this ...

journal_title：Epigenetics

authors： Wang Y,Pedersen NL,Hägg S

更新日期：2018-01-01 00:00:00

abstract：:DNA methylation in post-mitotic neurons is reported to serve a variety of functions from survival during development to the consolidation of memory. Of particular interest with regards neuronal functioning is the change in site-specific methylation of a variety of gene promoters in the context of neuronal depolarizati...

journal_title：Epigenetics

authors： Sharma RP,Tun N,Grayson DR

更新日期：2008-03-01 00:00:00

abstract：:One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicit principle is that a particular cofactor is necessary at all the target genes where the cofactor is recruited. Increasingly, t...

journal_title：Epigenetics

authors： Bedford DC,Kasper LH,Fukuyama T,Brindle PK

更新日期：2010-01-01 00:00:00

abstract：:The etiology of the major psychotic disorders, including schizophrenia and bipolar disorder, remains poorly understood. Postmortem brain studies have revealed altered expression of multiple mRNAs, affecting neurotransmission, metabolism, myelination and other functions. Epigenetic mechanisms could be involved, because...

journal_title：Epigenetics

authors： Connor CM,Akbarian S

更新日期：2008-03-01 00:00:00

abstract：:Human immunodeficiency virus (HIV) infection and the psychostimulant drug cocaine are known to induce epigenetic changes in DNA methylation that are linked with the severity of viral replication and disease progression, which impair neuronal functions. Increasing evidence suggests that changes in DNA methylation and h...

journal_title：Epigenetics

authors： Doke M,Jeganathan V,McLaughlin JP,Samikkannu T

更新日期：2020-10-24 00:00:00

abstract：:Previous studies have uncovered several transcription factors that determine biological alterations in tumor cells to execute the invasion-metastasis cascade, including the epithelial-mesenchymal transition (EMT). We sought to investigate the role of miR-21 in colorectal cancer regulation. For this purpose, miR-21 exp...

journal_title：Epigenetics

authors： Ferraro A,Kontos CK,Boni T,Bantounas I,Siakouli D,Kosmidou V,Vlassi M,Spyridakis Y,Tsipras I,Zografos G,Pintzas A

更新日期：2014-01-01 00:00:00

abstract：:Polycomb group (PcG) genes encode chromatin associated proteins that usually form polycomb repressive complexes (PRC) to maintain the repressive state of gene transcription. In both embryonic and adult stem cells, PRCs are commonly regarded as essential players for maintaining stem cell multipotency by repressing deve...

journal_title：Epigenetics

authors： Su Y,Deng B,Xi R

更新日期：2011-01-01 00:00:00

abstract：:Cadmium (Cd) is prevalent in the environment yet understudied as a developmental toxicant. Cd partially crosses the placental barrier from mother to fetus and is linked to detrimental effects in newborns. Here we examine the relationship between levels of Cd during pregnancy and 5-methylcytosine (5mC) levels in leukoc...

journal_title：Epigenetics

authors： Sanders AP,Smeester L,Rojas D,DeBussycher T,Wu MC,Wright FA,Zhou YH,Laine JE,Rager JE,Swamy GK,Ashley-Koch A,Lynn Miranda M,Fry RC

更新日期：2014-02-01 00:00:00

abstract：:In mammals, the time period that follows fertilization is characterized by extensive chromatin remodeling, which enables epigenetic reprogramming of the gametes. Major changes in chromatin structure persist until the time of implantation, when the embryo develops into a blastocyst, which comprises the inner cell mass ...

journal_title：Epigenetics

authors： Ziegler-Birling C,Daujat S,Schneider R,Torres-Padilla ME

更新日期：2016-08-02 00:00:00

abstract：:Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms. ...

journal_title：Epigenetics

authors： Yu Q

更新日期：2008-11-01 00:00:00

abstract：:We have developed a rapid and sensitive quantitative assay for the measurement of individual allelic ratios. This assay minimizes time and labor, the need for special restriction endonuclease enzymes for polymorphic sites, and avoids heteroduplex formation seen with traditional quantitative PCR-based methods. It has i...

journal_title：Epigenetics

authors： Yang B,Wagner J,Yao T,Damaschke N,Jarrard DF

更新日期：2013-10-01 00:00:00

abstract：:Constitutional epigenetic changes detected in blood or non-disease involving tissues have been associated with disease susceptibility. We measured promoter methylation of CDKN2A (p16 and p14ARF) and 13 melanoma-related genes using bisulfite pyrosequencing of blood DNA from 114 cases and 122 controls in 64 melanoma-pro...

journal_title：Epigenetics

authors： Hyland PL,Burke LS,Pfeiffer RM,Rotunno M,Sun D,Patil P,Wu X,Tucker MA,Goldstein AM,Yang XR

更新日期：2014-05-01 00:00:00