Implementing a method for studying longitudinal DNA methylation variability in association with age.

abstract：BACKGROUND:Epigenetic markers are often quantified and related to disease in stored samples. While, effects of storage on stability of these markers have not been thoroughly examined. In this longitudinal study, we investigated the influence of storage time, material, temperature, and freeze-thaw cycles on stability of...

journal_title：Epigenetics

authors： Gosselt HR,Griffioen PH,van Zelst BD,Oosterom N,de Jonge R,Heil SG

更新日期：2020-07-02 00:00:00

abstract：:Temporal and spatial control of Hox gene expression is essential for correct patterning of many animals. In both Drosophila and vertebrates, Polycomb and Trithorax group complexes control the maintenance of Hox gene expression in appropriate domains. In vertebrates, dynamic changes in chromatin modifications are also ...

journal_title：Epigenetics

authors： Soshnikova N,Duboule D

更新日期：2009-11-16 00:00:00

abstract：:Early embryonic development is characterized by dramatic changes in cell potency and chromatin organization. The role of histone variants in the context of chromatin remodeling during embryogenesis remains under investigated. In particular, the nuclear distribution of the histone variant H2A.Z and its modifications ha...

journal_title：Epigenetics

authors： Bošković A,Bender A,Gall L,Ziegler-Birling C,Beaujean N,Torres-Padilla ME

更新日期：2012-07-01 00:00:00

abstract：:One general principle of gene regulation is that DNA-binding transcription factors modulate transcription by recruiting cofactors that modify histones and chromatin structure. A second implicit principle is that a particular cofactor is necessary at all the target genes where the cofactor is recruited. Increasingly, t...

journal_title：Epigenetics

authors： Bedford DC,Kasper LH,Fukuyama T,Brindle PK

更新日期：2010-01-01 00:00:00

abstract：:TAL1/SCL (hereafter referred to as TAL1) is a critical transcription factor required for hematopoiesis in which hematopoietic stem cells commit and differentiate to different lineages. During this process, transcription of many genes is turned on and off in part by epigenetic mechanisms. TAL1 has recently been shown t...

journal_title：Epigenetics

authors： Hu X,Ybarra R,Qiu Y,Bungert J,Huang S

更新日期：2009-08-16 00:00:00

abstract：:As evidence for the existence of brain-expressed imprinted genes accumulates, we need to address exactly what they are doing in this tissue, especially in terms of organizational themes and the major challenges posed by reconciling imprinted gene action in brain with current evolutionary theories attempting to explain...

journal_title：Epigenetics

authors： Davies W,Isles AR,Humby T,Wilkinson LS

更新日期：2007-10-01 00:00:00

abstract：:Altered expression of microRNAs (miRNAs) is implicated in fetal growth. However, the mechanisms by which placenta-derived miRNAs regulate birthweight are not well understood. In Phase 1, we compared the expression of 754 miRNAs in the placenta of mothers from two extreme birthweight groups (0.8-2.2 kg vs. 3.3-3.9 kg, ...

journal_title：Epigenetics

authors： Rahman ML,Liang L,Valeri L,Su L,Zhu Z,Gao S,Mostofa G,Qamruzzaman Q,Hauser R,Baccarelli A,Christiani DC

更新日期：2018-01-01 00:00:00

abstract：:ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability through the regulation of repetitive sequences, such as rDNA, retrotransposons, and pericentromeric and telomeric repeats. However, few direct ATRX target genes have been identified and high-throughput genomic approaches are currently lacking f...

journal_title：Epigenetics

authors： Valle-García D,Qadeer ZA,McHugh DS,Ghiraldini FG,Chowdhury AH,Hasson D,Dyer MA,Recillas-Targa F,Bernstein E

更新日期：2016-06-02 00:00:00

abstract：:Breast cancer (BC) is a disease with diverse tumor heterogeneity, which challenges conventional approaches to develop biomarkers for early detection and prognosis. To identify effective biomarkers, we performed a genome-wide screen for functional methylation changes in BC, i.e., genes silenced by promoter hypermethyla...

journal_title：Epigenetics

authors： Jeschke J,Van Neste L,Glöckner SC,Dhir M,Calmon MF,Deregowski V,Van Criekinge W,Vlassenbroeck I,Koch A,Chan TA,Cope L,Hooker CM,Schuebel KE,Gabrielson E,Winterpacht A,Baylin SB,Herman JG,Ahuja N

更新日期：2012-07-01 00:00:00

abstract：:Chromatin is broadly compartmentalized in two defined states: euchromatin and heterochromatin. Generally, euchromatin is trimethylated on histone H3 lysine 4 (H3K4(me3)) while heterochromatin contains the H3K9(me3) marks. The H3K9(me3) modification is added by lysine methyltransferases (KMTs) such as SETDB1. Herein, w...

journal_title：Epigenetics

authors： Binda O,LeRoy G,Bua DJ,Garcia BA,Gozani O,Richard S

更新日期：2010-11-01 00:00:00

abstract：:Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC). In the present study, we performed high-throughput sequencing to determine the m6A methylome in CRC. ...

journal_title：Epigenetics

authors： Zhang Z,Wang Q,Zhang M,Zhang W,Zhao L,Yang C,Wang B,Jiang K,Ye Y,Shen Z,Wang S

更新日期：2020-08-12 00:00:00

abstract：:Neuroblastoma is a very heterogeneous tumor of childhood. The clinical spectra range from very aggressive metastatic disease to spontaneous regression, even without therapy. Aberrant DNA methylation pattern is a common feature of most cancers. For neuroblastoma, it has been demonstrated both for single genes as well a...

journal_title：Epigenetics

authors： Olsson M,Beck S,Kogner P,Martinsson T,Carén H

更新日期：2016-01-01 00:00:00

abstract：:Illumina HumanMethylation450 BeadChip (450K) has been commonly used to investigate DNA methylation in human tissues. Recently, it has been replaced by Illumina HumanMethylationEPIC BeadChip (EPIC) covering over 850,000 CpGs distributed genome-wide. Many consortia have now datasets coming from both arrays and aspire to...

journal_title：Epigenetics

authors： Fernandez-Jimenez N,Allard C,Bouchard L,Perron P,Bustamante M,Bilbao JR,Hivert MF

更新日期：2019-12-01 00:00:00

abstract：:Anniston, Alabama was home to a major polychlorinated biphenyl (PCB) production facility from 1929 until 1971. The Anniston Community Health Survey I and II (ACHS-I 2005-2007, ACHS-II 2013-2014) were conducted to explore the effects of PCB exposures. In this report we examined associations between PCB exposure and DNA...

journal_title：Epigenetics

authors： Pittman GS,Wang X,Campbell MR,Coulter SJ,Olson JR,Pavuk M,Birnbaum LS,Bell DA

更新日期：2020-04-01 00:00:00

abstract：:The dysregulation of genes in neurodevelopmental disorders that lead to social and cognitive phenotypes is a complex, multilayered process involving both genetics and epigenetics. Parent-of-origin effects of deletion and duplication of the 15q11-q13 locus leading to Angelman, Prader-Willi, and Dup15q syndromes are due...

journal_title：Epigenetics

authors： Lopez SJ,Dunaway K,Islam MS,Mordaunt C,Vogel Ciernia A,Meguro-Horike M,Horike SI,Segal DJ,LaSalle JM

更新日期：2017-01-01 00:00:00

abstract：:Parent-of-origin specific expression of imprinted genes relies on the differential DNA methylation of specific genomic regions. Differentially methylated regions (DMRs) acquire DNA methylation either during gametogenesis (primary DMR) or after fertilisation when allele-specific expression is established (secondary DMR...

journal_title：Epigenetics

authors： Wood MD,Hiura H,Tunster SJ,Arima T,Shin JY,Higgins MJ,John RM

更新日期：2010-04-01 00:00:00

abstract：:The centromere is a key region for cell division where the kinetochore assembles, recognizes and attaches to microtubules so that each sister chromatid can segregate to each daughter cell. The centromeric chromatin is a unique rigid chromatin state promoted by the presence of the histone H3 variant CENP-A, in which ep...

journal_title：Epigenetics

authors： González-Barrios R,Soto-Reyes E,Herrera LA

更新日期：2012-01-01 00:00:00

abstract：:Patients with paediatric-onset systemic lupus erythematosus (SLE) often present with more severe clinical courses than adult-onset patients. Although genome-wide DNA methylation (DNAm) profiling has been performed in adult-onset SLE patients, parallel data on paediatric-onset SLE are not available. Therefore, we under...

journal_title：Epigenetics

authors： Yeung KS,Lee TL,Mok MY,Mak CCY,Yang W,Chong PCY,Lee PPW,Ho MHK,Choufani S,Lau CS,Lau YL,Weksberg R,Chung BHY

更新日期：2019-04-01 00:00:00

abstract：:DNA methyltransferase 1 methylates hemi-methylated CG sites generated during DNA replication. Serine 515 of this enzyme has been shown to be phosphorylated. To explore the importance of S515 phosphorylation, we generated mutants of Dnmt1 which removed the phosphorylation potential (S515A) or mimic phosphoserine (S515E...

journal_title：Epigenetics

authors： Goyal R,Rathert P,Laser H,Gowher H,Jeltsch A

更新日期：2007-09-01 00:00:00

abstract：:Progression of cells through distinct phases of the cell cycle, and transition into out-of-cycling states, such as terminal differentiation and senescence, is accompanied by specific patterns of gene expression. These cell fate decisions are mediated not only by distinct transcription factors, but also chromatin modif...

journal_title：Epigenetics

authors： Rao VK,Pal A,Taneja R

更新日期：2017-03-04 00:00:00

abstract：:Aberrant DNA methylation is a major epigenetic mechanism of gene silencing in a wide range of human cancers. Previous studies on DNA methylation typically used paired tumor and normal-appearing surrounding tissues from cancer-bearing individuals. However, genomic DNA isolated from surrogate tissues such as blood cells...

journal_title：Epigenetics

authors： Vineis P,Chuang SC,Vaissière T,Cuenin C,Ricceri F,Genair-EPIC Collaborators.,Johansson M,Ueland P,Brennan P,Herceg Z

更新日期：2011-02-01 00:00:00

abstract：:Imprinted genes are differentially expressed in a parent-of-origin-specific manner. Parental origin of the alleles is discriminated by intragenic DNA polymorphisms. Comparisons of parental allelic expression have been analysed by semiquantitative RT-PCR. Here, we developed a novel quantitative method for allelic expre...

journal_title：Epigenetics

authors： Mitake M,Hirano S,Kishino T

更新日期：2020-09-24 00:00:00

abstract：:The discovery of new biomarkers would be very valuable to improve the detection of early Alzheimer's disease (AD). DNA methylation marks may serve as epigenetic biomarkers of early AD. Here we identified epigenetic marks that are present in the human hippocampus from the earliest stages of AD. A previous methylome dat...

journal_title：Epigenetics

authors： Blanco-Luquin I,Acha B,Urdánoz-Casado A,Sánchez-Ruiz De Gordoa J,Vicuña-Urriza J,Roldán M,Labarga A,Zelaya MV,Cabello C,Méndez-López I,Mendioroz M

更新日期：2020-10-01 00:00:00

abstract：:During mouse development, imprinted X chromosome inactivation (XCI) is observed in preimplantation embryos and is inherited to the placental lineage, whereas random XCI is initiated in the embryonic proper. Xist RNA, which triggers XCI, is expressed ectopically in cloned embryos produced by somatic cell nuclear transf...

journal_title：Epigenetics

authors： Oikawa M,Inoue K,Shiura H,Matoba S,Kamimura S,Hirose M,Mekada K,Yoshiki A,Tanaka S,Abe K,Ishino F,Ogura A

更新日期：2014-02-01 00:00:00

abstract：:5-Aza-2'-deoxycytidine (decitabine) is a drug targeting the epigenetic abnormalities of tumors. The basis for its limited efficacy in solid tumors is unresolved, but may relate to their indolent growth, their p53 genotype or both. We report that the primary molecular mechanism of decitabine-depletion of DNA methyltran...

journal_title：Epigenetics

authors： Al-Salihi M,Yu M,Burnett DM,Alexander A,Samlowski WE,Fitzpatrick FA

更新日期：2011-08-01 00:00:00

abstract：:TET2 enzymatically converts 5-methyl-cytosine to 5-hydroxymethyl-cytosine, possibly leading to loss of DNA methylation. TET2 mutations are common in myeloid leukemia and were proposed to contribute to leukemogenesis through DNA methylation. To expand on this concept, we studied chronic myelomonocytic leukemia (CMML) s...

journal_title：Epigenetics

authors： Yamazaki J,Taby R,Vasanthakumar A,Macrae T,Ostler KR,Shen L,Kantarjian HM,Estecio MR,Jelinek J,Godley LA,Issa JP

更新日期：2012-02-01 00:00:00

abstract：:Hypertension-associated end-organ damage commonly leads to cardiac and renal fibrosis. As no effective anti-fibrotic therapy currently exists, the unchecked progression of fibrogenesis manifests as cardio-renal failure and early death. We have previously shown that FATp300-p300 with intrinsic factor acetyltransferase ...

journal_title：Epigenetics

authors： Rai R,Verma SK,Kim D,Ramirez V,Lux E,Li C,Sahoo S,Wilsbacher LD,Vaughan DE,Quaggin SE,Ghosh AK

更新日期：2017-01-01 00:00:00

abstract：:microRNAs (miRNAs) are key posttranscriptional regulators of gene expression. In the present study, regulation of tumor-suppressor gene D-glucuronyl C5-epimerase (GLCE) by miRNA-218 was investigated. Significant downregulation of miRNA-218 expression was shown in primary breast tumors. Exogenous miRNA-218/anti-miRNA-2...

journal_title：Epigenetics

authors： Prudnikova TY,Mostovich LA,Kashuba VI,Ernberg I,Zabarovsky ER,Grigorieva EV

更新日期：2012-10-01 00:00:00

abstract：:Beckwith-Wiedemann syndrome (BWS) is an imprinting disorder that can be prenatally suspected or diagnosed based on established clinical guidelines. Molecular confirmation is commonly performed on amniocytes. The possibility to use fresh (CVF) and cultured (CVC) chorionic villi has never been investigated. To verify wh...

journal_title：Epigenetics

authors： Paganini L,Carlessi N,Fontana L,Silipigni R,Motta S,Fiori S,Guerneri S,Lalatta F,Cereda A,Sirchia S,Miozzo M,Tabano S

更新日期：2015-01-01 00:00:00

abstract：:Potential functional coordination between histone deubiquitinases and histone lysine demethylases represents one of the least studied aspects of epigenetic control of transcriptional outcomes. Here, this question was addressed using Arabidopsis histone modification erasers deubiquitinase OTLD1 and demethylase KDM1C kn...

journal_title：Epigenetics

authors： Keren I,Lapidot M,Citovsky V

更新日期：2019-06-01 00:00:00