Biologic Responses to Orthopedic Implants: Innate and Adaptive Immune Responses to Implant Debris.

Abstract:

:Almost 20% of joint replacement implants fail at 15 to 20 years. Reports suggest that systemic effects of metal-on-metal implants and local effects of total joint arthroplasty implants contributing to implant failure are immune system based. Sometimes implant wear debris can cause implant failure resulting from bone fracture, infection, or implant fracture/failure; most often, aseptic osteolysis or loosening leads to wear debris. Debris is produced by wear (primary) or by corrosion. Corrosion-chemical oxidation comprising reduction reactions involving electron transport-produces electrochemical degradation. Metallic implant degradation occurs when electrochemical dissolution and mechanical/physical wear are combined (i.e., tribocorrosion). With metal-on-metal implants, even with relatively low levels of wear and particle release, pathology caused by metal debris such as pseudotumor/fibrous tissue growth can lead to early implant failure.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Hallab NJ

doi

10.1097/BRS.0000000000001436

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

S30-1

eissn

0362-2436

issn

1528-1159

pii

00007632-201604017-00021

journal_volume

41 Suppl 7

pub_type

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