Volume versus standard coils in the treatment of intracranial aneurysms.


BACKGROUND:Volume coils were developed to improve occlusion rates of intracranial aneurysms. Previous studies have shown increased packing density and comparable occlusion rates, but subgroup analyses of aneurysm size have not been carried out. OBJECTIVE:To evaluate the safety and efficacy of the Penumbra Coil 400 (PC400) system in treating intracranial aneurysms compared with standard diameter coils. METHODS:A monocentric retrospective case review of 260 aneurysms in 233 patients was carried out. In 37 aneurysms the PC400 system was used, while 223 aneurysms were treated with conventional coils. Previously treated aneurysms and aneurysms treated with flow diverters were excluded. Aneurysm and procedure characteristics, packing density, postprocedural and follow-up occlusion grades as well as coil compaction were evaluated. RESULTS:Aneurysms treated with PC400 coils had higher volume (218.9 vs 47.1 mm(3), p<0.001), wider necks (3.0 vs 2.5 mm, p=0.005), and greater dome/neck ratio (2.0 vs 1.6, p=0.001) in comparison with aneurysms treated with conventional coils. Compared with controls, in the PC400 group we achieved higher packing densities (43.2% vs 34.4%, p<0.001; in aneurysms ≥7 mm 42.2% vs 27.8%, p<0.001). On follow-up angiography we observed less coil compaction (23.8% vs 64.3%, p=0.003) and less aneurysm recurrence (14.3% vs 40.5%, p=0.046) in aneurysms ≥7 mm when using the PC400 system. CONCLUSIONS:Use of the PC400 system as opposed to conventional coils suggests that the PC400 system is safe and effective in treating intracranial aneurysms. Despite having been applied in a potentially more difficult-to-treat group, the use of PC400 was associated with less coil compaction and aneurysm recurrence in aneurysms ≥7 mm.


J Neurointerv Surg


Kaesmacher J,Müller-Leisse C,Huber T,Boeckh-Behrens T,Haller B,Shiban E,Friedrich B,Zimmer C,Dorn F,Prothmann S




Has Abstract


2016-10-01 00:00:00














  • Successful use of percutaneous interspinous spacers and adjunctive spinoplasty in a 9 year cohort of patients.

    abstract:PURPOSE:Lumbar spinal canal stenosis and lumbar spinal foraminal stenosis are common, degenerative pathologies which can result in neurogenic claudication and have a negative impact on function and quality of life. Percutaneous interspinous devices (PIDs) are a recently-developed, minimally-invasive, alternative treatm...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Manfre L,De Vivo AE,Al Qatami H,Own A,Ventura F,Zhou K,Chandra RV,Hirsch JA

    更新日期:2020-07-01 00:00:00

  • Feasibility of repeat transradial access for neuroendovascular procedures.

    abstract:INTRODUCTION:Transradial artery access (TRA) for cerebrovascular angiography is increasing due to decreased access site complications and overwhelming patient preference. While interventional cardiologists have reported up to 10 successive TRA procedures via the same radial access site, this is the first study examinin...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Chen SH,Brunet MC,Sur S,Yavagal DR,Starke RM,Peterson EC

    更新日期:2020-04-01 00:00:00

  • Impact of WASID and Wingspan on the frequency of intracranial angioplasty and stenting at a high volume tertiary care hospital.

    abstract:BACKGROUND AND PURPOSE:The impact of the Warfarin and Aspirin for Symptomatic Intracranial Disease (WASID) data is described in combination with the commercial release of the Wingspan stenting system on the frequency of neurointervention for the treatment of symptomatic intracranial atherosclerotic disease (ICAD) in a ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Moskowitz SI,Kelly ME,Obuchowski N,Fiorella D

    更新日期:2009-12-01 00:00:00

  • Rates of local procedural-related structural injury following clipping or coiling of anterior communicating artery aneurysms.

    abstract:BACKGROUND:Surgical clipping and endovascular coiling yield similar functional outcomes for the treatment of saccular aneurysms of the anterior communicating (ACOM) artery. However, surgical treatment may be associated with greater rates of cognitive impairment due to injury of adjacent structures. We aimed to quantify...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Mortimer AM,Steinfort B,Faulder K,Erho T,Scherman DB,Rao PJ,Harrington T

    更新日期:2016-03-01 00:00:00

  • Mechanical embolectomy for treatment of large vessel acute ischemic stroke in children.

    abstract:BACKGROUND AND PURPOSE:The three largest adult stroke trials investigating mechanical embolectomy retrieval devices in acute stroke (the Merci, Multi Merci and Penumbra Pivotal Stroke Trials) excluded children. There is a need to expand the literature on mechanical embolectomy in large vessel pediatric arterial ischemi...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Tatum J,Farid H,Cooke D,Fullerton H,Smith W,Higashida R,Halbach VV,Dowd C

    更新日期:2013-03-01 00:00:00

  • Minimally invasive surgiscopic evacuation of intracerebral hemorrhage.

    abstract::Intracerebral hemorrhage (ICH) is a devastating form of stroke associated with a 40% mortality rate at 30 days and a 75% functional dependence rate at 6 months. The role of surgery to treat ICH remains controversial. Preclinical studies suggest minimally invasive clot evacuation following ICH may benefit patients by m...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Troiani Z,Ascanio LC,Yaeger KA,Ali M,Kellner CP

    更新日期:2020-09-08 00:00:00

  • Anomalous vertebral artery origins: the first and second reports of two variants.

    abstract::We present two cases of aberrant origins of vertebral arteries. Case 1 is of a patient undergoing evaluation of an infrarenal aortic aneurysm stent graft. Computed tomography (CT) angiogram revealed an aberrant right vertebral artery that subsequently joined a second right vertebral artery that had the typical origin ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Hsu DP,Alexander AD,Gilkeson RC

    更新日期:2010-06-01 00:00:00

  • Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models.

    abstract:BACKGROUND:Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. OBJECTIVE:To evaluate the navigability and clot retrieval performance of a novel 8Fr aspiration catheter, Millipede 088 (Perfuze Ltd), using fresh-frozen cadavers and an in vi...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Fitzgerald S,Ryan D,Thornton J,Nogueira RG

    更新日期:2020-06-30 00:00:00

  • Matricidal cavernous aneurysms: a multicenter case series.

    abstract:BACKGROUND:Cavernous carotid artery aneurysms (CCAs) represent a unique subset of intracranial aneurysms due to their distinct natural history and the anatomy of the cavernous sinus. Enlarging CCAs can cause elastic compression of the parent internal carotid artery (ICA). We suggest defining aneurysms that cause lumina...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Dacus MR,Nickele C,Welch BG,Ban VS,Ringer AJ,Kim LJ,Levitt MR,Lanzino G,Kan P,Arthur AS,Endovascular Neurosurgery Research Group (ENRG).

    更新日期:2019-06-01 00:00:00

  • Endovascular treatment of intracranial aneurysms using the Pipeline Flex embolization device: a case series of 30 consecutive patients.

    abstract:BACKGROUND:The Pipeline Flex embolization device has some peculiarities in comparison with the previous generation device. Despite recent reports of the modified delivery system, its safety is still unknown. OBJECTIVE:To illustrate the intraprocedural and periprocedural complication rate with this new device in 30 con...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Martínez-Galdámez M,Pérez S,Vega A,Ruiz P,Caniego JL,Bárcena E,Saura P,Méndez JC,Delgado F,Ortega-Gutierrez S,Romance A,Diaz T,Gonzalez E,Gil A,Murias E,Vega P

    更新日期:2016-04-01 00:00:00

  • Infectious mid basilar artery aneurysm from Pseudomonas meningitis.

    abstract::Pseudomonas aeruginosa meningitis is an uncommon complication of neurosurgical procedures or head trauma. Here, a case of infectious mid basilar artery aneurysm from Pseudomonas meningitis, and its angiographic remission from timely antibiotic therapy, is reported. ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Yu W,Rickert K,Flores B,Samson D

    更新日期:2012-05-01 00:00:00

  • Transvenous embosurgery of a left sigmoid sinus dural arteriovenous fistula via a retrograde approach from the superior ophthalmic vein, cavernous and inferior petrosal sinuses.

    abstract::The efficacy and safety of transvenous embosurgery for sigmoid sinus dural arteriovenous fistula (DAVF) using the internal jugular vein approach is well known. Embosurgery of cavernous sinus DAVF has also been described utilizing a superior ophthalmic vein approach. The first report of a sigmoid sinus DAVF endosurgica...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Patel DV,Rangaswamy R,Lesley WS,Hester JL,McDonald DK,Tsai JH

    更新日期:2011-09-01 00:00:00

  • Direct transforaminal Onyx embolization of intracranial dural arteriovenous fistulas: technical note and report of five cases.

    abstract::Intracranial dural arteriovenous fistulas with retrograde leptomeningeal or cortical drainage are considered aggressive. Conventional treatment in these cases is possible surgically or with endovascular arterial injections of Onyx or cyanoacrylate, but there are still some cases where distal navigation is not possible...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Saura P,Saura J,Pérez-Higueras A,Martínez-Galdámez M

    更新日期:2014-09-01 00:00:00

  • Vertebral body stent augmentation to reconstruct the anterior column in neoplastic extreme osteolysis.

    abstract:BACKGROUND:Extensive lytic lesions of the vertebral body (VB) increase risk of fracture and instability and require stabilization of the anterior column. Vertebral augmentation is an accepted treatment option, but when osteolysis has extensively destroyed the VB cortical boundaries (a condition herein defined as 'extre...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Cianfoni A,Distefano D,Pravatà E,Espeli V,Pesce G,Mordasini P,La Barbera L,Scarone P,Bonaldi G

    更新日期:2019-03-01 00:00:00

  • Mechanical thrombectomy of M1 and M2 middle cerebral artery occlusions.

    abstract:BACKGROUND:Over half of patients who receive intravenous tissue plasminogen activator for middle cerebral artery division (MCA-M2) occlusion do not recanalize, leaving a large percentage of patients who may need mechanical thrombectomy (MT). However, the outcomes of MT for M2 occlusion have not been well characterized....

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Salahuddin H,Ramaiah G,Slawski DE,Shawver J,Buehler M,Zaidi SF,Jumaa M

    更新日期:2018-04-01 00:00:00

  • Early results of the Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm (AMERICA) study: a multicenter prospective observational registry.

    abstract:BACKGROUND:Axium MicroFX coils contain polymer (polyglycolic/polylactic acid, PGLA) microfilaments designed to significantly impact intra-aneurysmal flow and to encourage aneurysm thrombosis. To provide preliminary evaluation of the safety and suggested efficacy of the MicroFX design, we performed a multicenter prospec...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Fargen KM,Blackburn S,Carpenter JS,Jabbour P,Mack WJ,Rai AT,Siddiqui AH,Turner RD,Mocco J

    更新日期:2014-09-01 00:00:00

  • Improvement of working memory after stenting for cervicocerebral artery stenosis.

    abstract:OBJECTIVE:To investigate the working memory of patients with cervicocerebral artery stenosis and its change after stenting. METHODS:35 patients with cervicocerebral artery stenosis (≥50% with related symptoms of cerebral ischemia, or ≥70% with or without related symptoms of cerebral ischemia) underwent endovascular st...

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    pub_type: 临床试验,杂志文章


    authors: He ZJ,Qin B,Cui Z,Liu F,Qi P,Lu J,Liu JC,Wang LJ,Zeng P,Wang DM

    更新日期:2014-06-01 00:00:00

  • The use of gadolinium chelates as an alternative radiographic contrast agent for use with flat panel detector angiography.

    abstract::Gadolinium chelates can be utilized as a fluoroscopic contrast agent when iodinated contrast is contraindicated. However, the nephrotoxicity of gadolinium at radiographic doses limits its role as fluoroscopic contrast. Gadolinium chelate-enhanced digital subtraction angiography (DSA) is particularly limited by the kV ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Hui FK,Tong FC,Dion JE

    更新日期:2011-03-01 00:00:00

  • Endovascular management of spinal arteriovenous malformations.

    abstract::Spinal arteriovenous malformations (sAVMs) are rare vascular lesions whose natural history remains incompletely defined. Several classification schemes for sAVMs have evolved based on an improved understanding of the anatomic characteristics as well as pathophysiologic behavior of these arteriovenous shunts. Advances ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审


    authors: Ducruet AF,Crowley RW,McDougall CG,Albuquerque FC

    更新日期:2013-11-01 00:00:00

  • Rupture Resemblance Score (RRS): toward risk stratification of unruptured intracranial aneurysms using hemodynamic-morphological discriminants.

    abstract:OBJECTIVE:We have previously developed three logistic regression models for discriminating intracranial aneurysm rupture status from 119 aneurysms based on hemodynamic-morphological parameters. In this study we exploit their use as a tool for predicting the risk of rupture of aneurysms with a defined Rupture Resemblanc...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Xiang J,Yu J,Choi H,Dolan Fox JM,Snyder KV,Levy EI,Siddiqui AH,Meng H

    更新日期:2015-07-01 00:00:00

  • Hemodynamic characteristics of stable and unstable vertebrobasilar dolichoectatic and fusiform aneurysms.

    abstract:BACKGROUND AND PURPOSE:Vertebrobasilar dolichoectatic and fusiform aneurysms (VBDAs) are known to have a poor natural history, with high rates of growth, rupture, and stroke. The purpose of this study was to identify hemodynamic characteristics that differ between VBDAs associated with growth, rupture, and stroke. MAT...

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    authors: Brinjikji W,Chung B,Yong-Hong D,Wald JT,Mut F,Kadirvel R,Kallmes DF,Rouchaud A,Lanzino G,Cebral JR

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  • Periconal arterial anastomotic circle and posterior lumbosacral watershed zone of the spinal cord.

    abstract:BACKGROUND:The existence of spinal cord watershed territories was suggested in the 1950s. Segmental infarcts within the junctional territories of adjacent radiculomedullary contributors and isolated spinal gray matter ischemia constitute two well-recognized types of watershed injury. This report describes the existence...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Gailloud P,Gregg L,Galan P,Becker D,Pardo C

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  • Clinical, morphological, and hemodynamic independent characteristic factors for rupture of posterior communicating artery aneurysms.

    abstract:OBJECTIVE:To identify clinical, morphological, and hemodynamic independent characteristic factors that discriminate posterior communicating artery (PCoA) aneurysm rupture status. METHODS:173 patients with single PCoA aneurysms (108 ruptured, 65 unruptured) between January 2012 and June 2014 were retrospectively collec...

    journal_title:Journal of neurointerventional surgery

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    authors: Zhang Y,Jing L,Liu J,Li C,Fan J,Wang S,Li H,Yang X

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  • Endovascular approach and technique for treatment of transverse-sigmoid dural arteriovenous fistula with cortical reflux: the importance of venous sinus sacrifice.

    abstract:BACKGROUND:Treatment of dural arteriovenous fistula involving the transverse-sigmoid region with cortical reflux is complex and treatment options may require sacrifice of the fistulous segment of the sinus. OBJECTIVE:To review our results in this subset of patients and describe current endovascular decision-making and...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Carlson AP,Alaraj A,Amin-Hanjani S,Charbel FT,Aletich V

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  • Emergency medical systems education may improve knowledge of pre-hospital stroke triage protocols.

    abstract:BACKGROUND:Following the results of randomized clinical trials supporting the use of mechanical thrombectomy (MT) with tissue plasminogen activator for emergent large vessel occlusion (ELVO), our state Stroke Task Force convened to: update legislation to recognize differences between Primary Stroke Centers (PSCs) and C...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: DiBiasio EL,Jayaraman MV,Oliver L,Paolucci G,Clark M,Watkins C,DeLisi K,Wilks A,Yaghi S,Hemendinger M,Baird GL,Oostema JA,McTaggart RA

    更新日期:2020-04-01 00:00:00

  • Percutaneous sacroplasty.

    abstract::The recognition of sacral insufficiency fractures continues to be poor, and diagnosis is often delayed resulting in significant morbidity. Percutaneous sacroplasty is an image guided procedure that is safe and potentially effective for treating the pain and disability related to these fractures. Several cohort studies...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审


    authors: Gupta AC,Yoo AJ,Stone J,Barr JC,Brook A,Tutton S,Ortiz O,Hirsch AE,Larvie M,Frey ME,Jayaraman MV,Hirsch JA

    更新日期:2012-09-01 00:00:00

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    abstract::Component coding is the method NeuroInterventionalists have used for the past 20 years to bill procedural care. The term refers to separate billing for each discrete aspect of a surgical or interventional procedure, and has typically allowed billing the procedural activity, such as catheterization of vessels, separate...

    journal_title:Journal of neurointerventional surgery

    pub_type: 历史文章,杂志文章


    authors: Hirsch JA,Donovan WD,Leslie-Mazwi TM,Nicola GN,Manchikanti L,Silva E 3rd

    更新日期:2013-11-01 00:00:00

  • Endovascular management of intracranial blister aneurysms: spectrum and limitations of contemporary techniques.

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    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Ashour R,Dodson S,Aziz-Sultan MA

    更新日期:2016-01-01 00:00:00

  • Risk of distal embolization with stent retriever thrombectomy and ADAPT.

    abstract:BACKGROUND:There is a discrepancy in clinical outcomes and the achieved recanalization rates with stent retrievers in the endovascular treatment of ischemic stroke. It is our hypothesis that procedural release of embolic particulate may be one contributor to poor outcomes and is a modifiable risk. The goal of this stud...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Chueh JY,Puri AS,Wakhloo AK,Gounis MJ

    更新日期:2016-02-01 00:00:00

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    abstract::Occasionally an aneurysm is the cause of hemorrhage in patients with moyamoya disease (MMD). We present a case of a ruptured intraventricular distal anterior choroidal artery (AChA) aneurysm treated with n-butyl cyanoacrylic acid (nBCA) (Trufill nBCA Liquid Embolic, Codman Neurovascular, Raynham, Massachusetts, USA) e...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Choulakian A,Drazin D,Alexander MJ

    更新日期:2010-12-01 00:00:00