Volume versus standard coils in the treatment of intracranial aneurysms.


BACKGROUND:Volume coils were developed to improve occlusion rates of intracranial aneurysms. Previous studies have shown increased packing density and comparable occlusion rates, but subgroup analyses of aneurysm size have not been carried out. OBJECTIVE:To evaluate the safety and efficacy of the Penumbra Coil 400 (PC400) system in treating intracranial aneurysms compared with standard diameter coils. METHODS:A monocentric retrospective case review of 260 aneurysms in 233 patients was carried out. In 37 aneurysms the PC400 system was used, while 223 aneurysms were treated with conventional coils. Previously treated aneurysms and aneurysms treated with flow diverters were excluded. Aneurysm and procedure characteristics, packing density, postprocedural and follow-up occlusion grades as well as coil compaction were evaluated. RESULTS:Aneurysms treated with PC400 coils had higher volume (218.9 vs 47.1 mm(3), p<0.001), wider necks (3.0 vs 2.5 mm, p=0.005), and greater dome/neck ratio (2.0 vs 1.6, p=0.001) in comparison with aneurysms treated with conventional coils. Compared with controls, in the PC400 group we achieved higher packing densities (43.2% vs 34.4%, p<0.001; in aneurysms ≥7 mm 42.2% vs 27.8%, p<0.001). On follow-up angiography we observed less coil compaction (23.8% vs 64.3%, p=0.003) and less aneurysm recurrence (14.3% vs 40.5%, p=0.046) in aneurysms ≥7 mm when using the PC400 system. CONCLUSIONS:Use of the PC400 system as opposed to conventional coils suggests that the PC400 system is safe and effective in treating intracranial aneurysms. Despite having been applied in a potentially more difficult-to-treat group, the use of PC400 was associated with less coil compaction and aneurysm recurrence in aneurysms ≥7 mm.


J Neurointerv Surg


Kaesmacher J,Müller-Leisse C,Huber T,Boeckh-Behrens T,Haller B,Shiban E,Friedrich B,Zimmer C,Dorn F,Prothmann S




Has Abstract


2016-10-01 00:00:00














  • Distinction between contrast staining and hemorrhage after endovascular stroke treatment: one CT is not enough.

    abstract:BACKGROUND:Postinterventional cerebral hyperdensities (PCHDs) are a common finding after endovascular stroke treatment. There is uncertainty about the extent to which PCHDs correspond to hemorrhage or contrast staining. Our aim was to evaluate the use of PCHD density on immediate postinterventional CT, and PCHD evoluti...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Dekeyzer S,Nikoubashman O,Lutin B,De Groote J,Vancaester E,De Blauwe S,Hemelsoet D,Wiesmann M,Defreyne L

    更新日期:2017-04-01 00:00:00

  • Rates of local procedural-related structural injury following clipping or coiling of anterior communicating artery aneurysms.

    abstract:BACKGROUND:Surgical clipping and endovascular coiling yield similar functional outcomes for the treatment of saccular aneurysms of the anterior communicating (ACOM) artery. However, surgical treatment may be associated with greater rates of cognitive impairment due to injury of adjacent structures. We aimed to quantify...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Mortimer AM,Steinfort B,Faulder K,Erho T,Scherman DB,Rao PJ,Harrington T

    更新日期:2016-03-01 00:00:00

  • Prospective assessment of pain and functional status after vertebroplasty for treatment of vertebral compression fractures.

    abstract:BACKGROUND AND PURPOSE:There has been no prospective evaluation of vertebroplasty using a validated instrument. We describe the pain and functional status of 72 patients before and after vertebroplasty, as prospectively evaluated by the Vertebral Compression Fracture Pain and Functional Disability Questionnaire. METHO...

    journal_title:Journal of neurointerventional surgery

    pub_type: 临床试验,杂志文章


    authors: Evans AJ,Kip KE,Boutin SM

    更新日期:2009-07-01 00:00:00

  • A novel approach to the treatment of a direct carotid-cavernous fistula in a patient with Ehlers-Danlos syndrome type IV.

    abstract::We report a case of a direct carotid-cavernous fistula (CCF) in a patient with Ehlers-Danlos syndrome type IV who presented with progressive chemosis and diplopia. To prevent potential lethal arterial wall injury due to the fragility of the arterial vessel wall, the ipsilateral carotid artery and internal jugular vein...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Nakagawa I,Park HS,Wada T,Takayama K,Nakagawa H,Kichikawa K,Nakase H

    更新日期:2016-01-01 00:00:00

  • Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model.

    abstract:BACKGROUND AND PURPOSE:Despite significant technical advances, recanalization rates after endovascular therapy of ruptured intracranial aneurysms (IAs) remain a clinical challenge. A histopathological hallmark of ruptured human IA walls is mural cell loss. Mural smooth muscle cells (SMCs) are known to promote intralumi...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Nevzati E,Rey J,Coluccia D,Grüter BE,Wanderer S,vonGunten M,Remonda L,Frosen J,Widmer HR,Fandino J,Marbacher S

    更新日期:2020-06-01 00:00:00

  • Dual-roadmap guidance for endovascular recanalization of medically refractory non-acute intracranial arterial occlusions: consecutive multicenter series and technical review.

    abstract:BACKGROUND:The optimal treatment for medically refractory non-acute intracranial artery occlusion is uncertain, and endovascular recanalization remains a technical challenge. Here, a multicenter clinical experience of dual-roadmap guidance for endovascular recanalization of non-acute intracranial artery occlusion is re...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Gao F,Guo X,Sun X,Liu Y,Wu Y,Miao Z

    更新日期:2020-10-26 00:00:00

  • Navigating a proximal loop in the radial artery and avoiding the recurrent radial artery.

    abstract::Several anatomical variations of the radial artery have been described in the literature. Common variations include radial artery loop, recurrent branch, and anastomotic channels connecting the radial and brachial arteries. These variations can pose significant technical challenges to safe radial artery catheterizatio...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Dossani R,Waqas M,Tso MK,Rajah GB,Smolar DE,Davies JM

    更新日期:2020-07-01 00:00:00

  • Mechanical thrombectomy in patients with acute cancer-related stroke: is the stent retriever alone effective?

    abstract:BACKGROUND:The optimal first-line mechanical thrombectomy (MT) method in cancer-related stroke (CRS) patients with emergent large vessel occlusion (ELVO) remains largely unknown. The aim of this study is to evaluate the efficacy and safety between contact aspiration (CA) first-line thrombectomy and stent retriever (SR)...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Jeon Y,Baik SH,Jung C,Kim JY,Kim BJ,Kang J,Bae HJ,Kim JH

    更新日期:2020-06-25 00:00:00

  • Mechanical thrombectomy for anterior circulation stroke: 5-year experience in a statewide service with differences in pretreatment time metrics across two hospitals sites.

    abstract:OBJECTIVE:To audit our institutional mechanical thrombectomy (MT) outcomes for acute anterior circulation stroke and examine the influence of workflow time metrics on patient outcomes. METHODS:A database of 100 MT cases was maintained throughout May 2010-February 2015 as part of a statewide service provided across two...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Kabra R,Phillips TJ,Saw JL,Phatouros CC,Singh TP,Hankey GJ,Blacker D,Ghia D,Prentice D,McAuliffe W

    更新日期:2017-06-01 00:00:00

  • Anomalous vertebral artery origins: the first and second reports of two variants.

    abstract::We present two cases of aberrant origins of vertebral arteries. Case 1 is of a patient undergoing evaluation of an infrarenal aortic aneurysm stent graft. Computed tomography (CT) angiogram revealed an aberrant right vertebral artery that subsequently joined a second right vertebral artery that had the typical origin ...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Hsu DP,Alexander AD,Gilkeson RC

    更新日期:2010-06-01 00:00:00

  • The impact of timing on outcomes of carotid artery stenting in recently symptomatic patients.

    abstract:OBJECTIVES:We sought to determine whether the timing of carotid artery stenting (CAS) affects peri-procedural outcomes in recently symptomatic patients. BACKGROUND:Early carotid endarterectomy following a stroke lowers the risk of recurrent ischemic events but has been associated with an increased risk of intracerebra...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Lin R,Mazighi M,Yadav J,Abou-Chebl A

    更新日期:2010-03-01 00:00:00

  • A novel approach to the management of carotid blowout syndrome: the use of thrombin in a case of failed covered stenting.

    abstract::Acute hemorrhage relating to an expanding pseudoaneurysm of the carotid artery is referred to as carotid blowout syndrome (CBS). CBS is associated with a high morbidity and mortality. We describe the case of a patient who presented with dysphagia and a pulsatile mass in the neck. Imaging revealed a pseudoaneurysm orig...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Sablani N,Jain G,Hasan MM,Sivakumar K,Feuerwerker S,Arcot K,Farkas J

    更新日期:2016-12-01 00:00:00

  • A novel model of large vessel ischemic stroke in rabbits: microcatheter occlusion of the posterior cerebral artery.

    abstract:BACKGROUND AND PURPOSE:The rabbit small clot embolic model for large vessel occlusion (LVO) is well established, yet has limitations. Blind introduction of autologous thrombus often fails to completely occlude a target vessel and, when successful, the precise timing of occlusion and revascularization is difficult to co...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: English JD,Hetts SW,El-Ali A,Kolli P,Do L,Wilson MW,Saeed M

    更新日期:2015-05-01 00:00:00

  • Preclinical evaluation of Millipede 088 intracranial aspiration catheter in cadaver and in vitro thrombectomy models.

    abstract:BACKGROUND:Larger bore aspiration catheters are expected to significantly improve the speed and completeness of acute stroke revascularization. OBJECTIVE:To evaluate the navigability and clot retrieval performance of a novel 8Fr aspiration catheter, Millipede 088 (Perfuze Ltd), using fresh-frozen cadavers and an in vi...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Fitzgerald S,Ryan D,Thornton J,Nogueira RG

    更新日期:2020-06-30 00:00:00

  • Factors associated with successful revascularization using the aspiration component of ADAPT in the treatment of acute ischemic stroke.

    abstract:INTRODUCTION:ADAPT (a direct aspiration first pass technique) has been shown to be fast, cost-effective, and associated with excellent angiographic and clinical outcomes in the treatment of acute ischemic stroke (AIS). OBJECTIVE:To identify any and all preoperative factors that are associated with successful revascula...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Mascitelli JR,Kellner CP,Oravec CS,De Leacy RA,Oermann EK,Yaeger K,Paramasivam S,Fifi JT,Mocco J

    更新日期:2017-07-01 00:00:00

  • Intracranial bailout stenting with the Acclino (Flex) Stent/NeuroSpeed Balloon Catheter after failed thrombectomy in acute ischemic stroke: a multicenter experience.

    abstract:BACKGROUND AND PURPOSE:To report on the feasibility, safety, and outcome of acute intracranial stenting (ICS) with the Acclino (Flex) Stent and NeuroSpeed Balloon Catheter in cases of failed mechanical thrombectomy (MT) for acute ischemic stroke (AIS). METHODS:We retrospectively reviewed the data of patients treated w...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,多中心研究


    authors: Stracke CP,Meyer L,Fiehler J,Leischner H,Bester M,Buhk JH,Thomalla G,Krause LU,Lowens S,Rothaupt J,Chapot R,Hanning U

    更新日期:2020-01-01 00:00:00

  • CT perfusion-guided patient selection for endovascular treatment of acute ischemic stroke is safe and effective.

    abstract:BACKGROUND:Traditional treatment in acute ischemic stroke is based on time criteria when administering intravenous and intra-arterial therapies. However, recent evidence suggests that image-based criteria may be useful for selecting patients for intra-arterial interventions. The use of CT perfusion (CTP)-based criteria...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Turk A,Magarik JA,Chaudry I,Turner RD,Nicholas J,Holmstedt CA,Chalela J,Hays A,Lazaridis C,Jauch E,Chimowitz M,Turan T,Adams R

    更新日期:2012-07-01 00:00:00

  • Crossing Y-Solitaire thrombectomy as a rescue treatment for refractory acute occlusions of the middle cerebral artery.

    abstract:BACKGROUND:Mechanical thrombectomy using a stent retriever has become the standard of care for acute large-vessel occlusions in the anterior circulation. Clots that are refractory to single stent retriever thrombectomy remain a challenge for neurointerventionalists. OBJECTIVE:To assess the efficacy and safety of doubl...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Aydin K,Barburoglu M,Oztop Cakmak O,Yesilot N,Vanli ENY,Akpek S

    更新日期:2019-03-01 00:00:00

  • Triage imaging and outcome measures for large core stroke thrombectomy - a systematic review and meta-analysis.

    abstract:BACKGROUND:Trials of endovascular thrombectomy (EVT) mostly excluded patients with large core strokes so the safety and efficacy of EVT is not well established in such patients. Moreover, the definition of large core and its measurement differ between semi-quantitative (ASPECTS) and quantitative (core volume) imaging m...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审


    authors: Sarraj A,Grotta JC,Pujara DK,Shaker F,Tsivgoulis G

    更新日期:2020-12-01 00:00:00

  • Combined proximal balloon occlusion and distal aspiration: a new approach to prevent distal embolization during neurothrombectomy.

    abstract:BACKGROUND AND PURPOSE:Embolization of thrombus fragments in a new vascular territory is a potential adverse event in neurothrombectomy. This study was performed to evaluate the safety and feasibility of a novel approach combining proximal balloon occlusion and distal aspiration to prevent distal thrombembolic complica...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Stampfl S,Pfaff J,Herweh C,Pham M,Schieber S,Ringleb PA,Bendszus M,Möhlenbruch MA

    更新日期:2017-04-01 00:00:00

  • Correlation of AOL recanalization, TIMI reperfusion and TICI reperfusion with infarct growth and clinical outcome.

    abstract:OBJECTIVE:To understand how three commonly used measures of endovascular therapy correlate with clinical outcome and infarct growth. METHODS:Prospectively enrolled patients underwent baseline MRI and started endovascular therapy within 12 h of stroke onset. The final angiogram was given a primary arterial occlusive le...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Marks MP,Lansberg MG,Mlynash M,Kemp S,McTaggart R,Zaharchuk G,Bammer R,Albers GW,DEFUSE 2 Investigators.

    更新日期:2014-12-01 00:00:00

  • Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever.

    abstract::Ischemic strokes in childhood are rare. Thrombolytic therapy with intravenous (IV) tissue plasminogen activator (tPA) has been the main intervention for the management of pediatric stroke patients, but safety data are lacking and efficacy has been questioned. Recently, successful endovascular treatments for acute isch...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Savastano L,Gemmete JJ,Pandey AS,Roark C,Chaudhary N

    更新日期:2016-08-01 00:00:00

  • Dermatitis caused by metal allergy after coil embolization for unruptured cerebral aneurysm.

    abstract::We report a rare case of metal-induced dermatitis after coil embolization for cerebral aneurysm. A 51-year-old woman experienced a rash around the lips and neck 3 weeks after coil embolization. Judging from the clinical course and results of several patch tests, platinum coils were considered to have induced the derma...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Uwatoko T,Tsumoto T,Wada N,Urabe K,Sanbongi Y,Tokunaga S,Tsurusaki Y,Okada Y

    更新日期:2016-10-01 00:00:00

  • Review of current and emerging therapies in acute ischemic stroke.

    abstract::The statistics for stroke in the USA reads like a familiar ad slogan cited in most papers pertaining to acute ischemic stroke (AIS). Stroke is the third leading cause of death in the USA. While stroke ranks third among all causes of death, behind diseases of the heart and cancer, it is the leading cause of serious lon...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,评审


    authors: Novakovic R,Toth G,Purdy PD

    更新日期:2009-07-01 00:00:00

  • Novel use of onyx for treatment of intracranial vertebral artery dissection.

    abstract::This report describes a patient who presented with subarachnoid hemorrhage and extensive right posterior inferior cerebellar artery territory infarct secondary to a dissecting aneurysm of the right intracranial vertebral artery. Urgent endovascular treatment was undertaken with plans for trapping of the diseased segme...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Oh DC,Hirsch JA,Yoo AJ

    更新日期:2012-01-01 00:00:00

  • Comparison of Solitaire thrombectomy and Penumbra suction thrombectomy in patients with acute ischemic stroke caused by basilar artery occlusion.

    abstract:BACKGROUND AND PURPOSE:Acute ischemic stroke (AIS) caused by basilar artery occlusion (BAO) is a very severe neurological disease with a high mortality rate and poor clinical outcomes. In this study, we compared our experience of mechanical thrombectomy using the Solitaire stent (Solitaire thrombectomy) and manual aspi...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Son S,Choi DS,Oh MK,Hong J,Kim SK,Kang H,Park KJ,Choi NC,Kwon OY,Lim BH

    更新日期:2016-01-01 00:00:00

  • Middle meningeal artery embolization as an adjuvant treatment to surgery for symptomatic chronic subdural hematoma: a pilot study assessing hematoma volume resorption.

    abstract:BACKGROUND:Chronic subdural hematoma (CSDH) is a common condition requiring surgical treatment; however, recurrence occurs in 15% of cases at 1 year. Middle meningeal artery (MMA) embolization has recently emerged as a promising treatment to prevent CSDH recurrence. OBJECTIVE:To investigate the effect of MMA embolizat...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章,随机对照试验


    authors: Ng S,Derraz I,Boetto J,Dargazanli C,Poulen G,Gascou G,Lefevre PH,Molinari N,Lonjon N,Costalat V

    更新日期:2020-07-01 00:00:00

  • Ultrasound for the evaluation of stenosis after flow diversion.

    abstract:BACKGROUND AND PURPOSE:Flow diversion is a relatively new strategy used to treat complex cerebral aneurysms. The optimal method for radiographic follow-up of patients treated with flow diverters has not been established. The rate and clinical implications of in-stent stenosis for these devices is unclear. We evaluate t...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: McDougall CM,Khan K,Saqqur M,Jack A,Rempel J,Derksen C,Xi Y,Chow M

    更新日期:2018-03-01 00:00:00

  • Balloon-mounted stents for acute intracranial large vessel occlusion secondary to presumed atherosclerotic disease: evolution in an era of supple intermediate catheters.

    abstract:INTRODUCTION:Treatment of acute large vessel occlusion (LVO) stroke secondary to intracranial atherosclerotic disease (ICAD) is more nuanced with disparate and infrequently reported outcomes. The deployment of balloon-mounted stents presents an expedient approach with renewed feasibility in the modern era of supple int...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Gross BA,Desai SM,Walker G,Jankowitz BT,Jadhav A,Jovin TG

    更新日期:2019-10-01 00:00:00

  • NBCA embolization of a ruptured intraventricular distal anterior choroidal artery aneurysm in a patient with moyamoya disease.

    abstract::Occasionally an aneurysm is the cause of hemorrhage in patients with moyamoya disease (MMD). We present a case of a ruptured intraventricular distal anterior choroidal artery (AChA) aneurysm treated with n-butyl cyanoacrylic acid (nBCA) (Trufill nBCA Liquid Embolic, Codman Neurovascular, Raynham, Massachusetts, USA) e...

    journal_title:Journal of neurointerventional surgery

    pub_type: 杂志文章


    authors: Choulakian A,Drazin D,Alexander MJ

    更新日期:2010-12-01 00:00:00