Memantine for treatment of moderate or severe Alzheimer's disease patients in urban China: clinical and economic outcomes from a health economic model.

Abstract:

OBJECTIVE:To estimate the clinical and economic benefits of memantine treatment initiated in moderate Alzheimer's disease (AD) in China, compared with initiation in severe AD only. METHODS:A Markov model with a 5-year time horizon simulated moderate patients' progression through health states. Two groups were compared: patients receiving memantine from the moderate stage (i.e., at model entry), continuing treatment when reaching the severe stage; patients initiating memantine only when they developed severe disease. RESULTS:After 5 years, fewer patients receiving memantine from the moderate stage were severe (49%), dependent (59%) or aggressive (47%) compared with moderate patients who initiated treatment from severe stage only (58, 67 and 55%, respectively). Total cost of care was lower for treatment from moderate stage (67 billion RMB) when compared with treatment from severe stage (73 billion RMB). CONCLUSIONS:In China, AD treatment with memantine from the moderate stage could result in substantial cost savings.

authors

Hu S,Yu X,Chen S,Clay E,Toumi M,Milea D

doi

10.1586/14737167.2015.1065734

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

565-78

issue

4

eissn

1473-7167

issn

1744-8379

journal_volume

15

pub_type

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