Abstract:
:Advanced hepatocellular carcinoma remains an entity that is hard to approach therapeutically and has shown disappointing results in terms of survival. For many years, the only accepted option for this setting was the use of a multikinase inhibitor, sorafenib. Nevertheless, through the years, a deeper knowledge has arisen about how pathogenic pathways correlate with hepatocellular carcinoma. In this review, we provide an update of the most recent data regarding new agents under investigation and new possible targets for future treatments.
journal_name
Minerva Chirjournal_title
Minerva chirurgicaauthors
Castañón Alvarez E,Giallombardo M,Gil-Bazo I,Papadimitriou K,Pauwels P,Peeters M,Rolfo Csubject
Has Abstractpub_date
2015-04-01 00:00:00pages
119-29issue
2eissn
0026-4733issn
1827-1626pii
R06Y9999N00A150003journal_volume
70pub_type
杂志文章,评审abstract::The Authors report a case of benign mucocele which was brought to their attention for emergency treatment. Following a review of the literature, they examine the clinical, anatomopathological, pathogenetic and therapeutic problems related to this rare disease. In conclusion, it is important to assess the benign nature...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1990-10-31 00:00:00
abstract::The authors describe their experience of the aneurysm popliteal artery. They analyze the symptomatology, the diagnostic way and the therapy of such disease. ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1995-09-01 00:00:00
abstract::This paper presents guidelines for the safe outpatient practice of aesthetic surgery. These guidelines have been prepared by the Lombard Association of Plastic Surgery for Outpatients (ALChiPlA), an association confined to board certified plastic surgeons and holders of official authorizations issued by the Lombard AS...
journal_title:Minerva chirurgica
pub_type: 杂志文章,实务指引
doi:
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:The conservative surgery is considered currently the treatment of choice for the carcinoma of the breast in the initial stage. METHODS:From 1993 to the 2000, 46 patients (median age 52 years) affected by intraductal carcinoma of the breast, have been submitted to surgical intervention. In 10 cases (21,7%) a...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-01 00:00:00
abstract::This paper is a critical review of the clinical records of 20 patients who underwent a Transduodenal Sphincteroplasty (PSP), from October 1990 to January 1992 at our Department (General Surgery). The age was 64.9 (14.2) years (mean and standard deviation), but 14 (70%) of those patients were older than 60 (range: 63 t...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1994-09-01 00:00:00
abstract::Successful resection of a leiomyoma of the epicardial segment of the oesophagus in a personal cases is reported. ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1976-03-31 00:00:00
abstract::The incidence and prevalence of obesity continues to increase globally. Physicians will therefore provide care for an increasing number of obese patients in their clinical practice. Optimal management of these patients is required to minimize the risk of perioperative complications that increase morbidity and mortalit...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4733.17.07310-2
更新日期:2017-06-01 00:00:00
abstract::Uniportal Video-Assisted Thoracic Surgery (uniportal VATS) lobectomy represents the last evolution of minimally invasive techniques for the surgical treatment of lung cancer. Uniportal VATS was developed from two-ports approach, with two main advantages: only one intercostal space is damaged and the direct view to the...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:2016-02-01 00:00:00
abstract::The Authors present their personal experience in the surgical treatment, using the Shouldice modified method, of 85 cases of patients suffering from inguinal hernia. The rarity of general and local complications and the relatively low percentage of relapse, if compared with other surgical methods, testify to the valid...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00
abstract:AIM:Systematic surveys with advanced non-invasive imaging techniques have revealed that hepatic cysts are quite common in the general population. Therefore, we retrospectively examined our case series and compared it with the literature. METHODS:Between January 1990 and December 2000, 228 patients with non-parasitic l...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::The authors report a retrospective study of four patients treated for sigmoid volvulus at the Clinica Chirurgica II of IRCCS Policlinico S. Matteo of Pavia between April 1974 and June 1989. They are collected from a series of 74 consecutive operations for colonic obstruction not related to hernias of the inguinal-crur...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1993-05-31 00:00:00
abstract::Explorative laparotomies and palliative surgery for pancreatic carcinoma have been reduced due to improved diagnostic tools, the spread of laparoscopic techniques and the growing use of external biliary drainage and endoprostheses. By comparing two successive observation periods the authors point out that, owing to th...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1993-12-01 00:00:00
abstract::After a wide analysis of peptic gastroduodenal ulcer medical therapy, before and after the era of cimetidine, the Authors, after a brief account of the Anatomy and Physiology of the stomach, examine surgical therapy, from the end of the last century till now. After giving the results of the surgical cases of one of th...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1990-04-30 00:00:00
abstract::Two cases of pancreatic cystadenocarcinoma, a very rare pathology, are reported. The authors treat the anatomopathological classification and they underline the diagnosis especially with reference to the new methods of cytologic study. Finally they consider the surgical approach that must be radical because of the pot...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1991-04-15 00:00:00
abstract::Two personally observed cases of ischaemia of the lower extremities due to thrombosis caused by a popliteal aneurysm are presented. While surgery is known to be treatment of choice, in these cases locoregional fibrinolysis was preferred. It seems useful to detail the advantages of this approach that has never appeared...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-05-31 00:00:00
abstract:BACKGROUND:Robotic complete mesocolic excision (CME) has recently emerged as promising technique to enhance oncologic results in hemicolectomy for cancer. The potential near-infrared (NIR) fluorescence with indocyanine-green (ICG) dye for lymphatic mapping is under investigation and few small case-series are reported. ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.18.07831-8
更新日期:2019-04-01 00:00:00
abstract:AIM:Postoperative air leaks and in particular persistent air leaks (>5 days) after pulmonary resection still represent a common complication and the first cause of hospital stay delay. Aim of this experimental trial was to investigate the efficacy of the use of bovine pericardium strips (in terms of reduction of postop...
journal_title:Minerva chirurgica
pub_type: 临床试验,杂志文章
doi:
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Spontaneous rupture is a life-threatening complication of HCC, occurring in 4.8-26% of cases. Liver failure is the main cause of death. Debates still remain on the most appropriate treatment in such patients because of the high operative mortality of emergency surgery and the high risk of rebleeding and less...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::The aim of the paper is to give a contribution to the understanding of the role of surgery in patients with N3 lung cancer. The A. describe their results on 32 patients with N3 lung cancer operated on mediastinectomy; histological examination of the specimens showed 27 squamous cell carcinomas and 5 adenocarcinomas. T...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:INTRODUCTION:We provide a comprehensive description of the physio-pathological theories behind oligometastatic prostate cancer (PCa) and analyze modern imaging techniques, presenting a systematic review of the available evidences regarding salvage lymph node dissection (sLND). EVIDENCE ACQUISITION:A systematic review ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.18.07796-9
更新日期:2019-02-01 00:00:00
abstract::Carotid-jugular arteriovenous fistulas (AVF) are extremely rare with only 20 cases reported in the literature up to December 1996. The case of a 74-year-old man (the oldest reported in the literature) with abnormal communications between the external carotid artery and the internal jugular vein is reported. The condit...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::Examination of the rectum by pathologists is instrumental in the management of patients affected by rectal carcinoma. That role includes evaluation of multiple gross and microscopic features that convey prognostic implications. The analysis is based on the authors' experience handling rectal specimens along with revie...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4733.18.07739-8
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Gastroduodenal obstruction is a preterminal event in patients with advanced and recurrent malignancies of the stomach, pancreas, and duodenum. It severely limits the quality of life in affected patients due to constant vomiting and associated malnutrition. Gastroduodenal stent placement is a very safe and ef...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.16.06457-9
更新日期:2017-06-01 00:00:00
abstract::The prevalence of obesity has increased three-fold in the past two decades. In Europe, 150.000.000 adults and 15.000.000 children are currently affected and obesity epidemic is responsible for approximately 1,000,000 deaths annually. Bariatric surgery for the severely obese has resulted in an overall of 61% weight red...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The past years have seen the development of outpatient treatment and surgical procedures for the treatment of hemorrhoid disease in an attempt to reduce postoperative pain on the one hand and execution and hospitalisation times on the other. METHODS:This retrospective study compares the results obtained in ...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::The authors relate their experience of 62 cases of minicholecystectomy. This procedure is compared to "open" conventional and laparoscopic cholecystectomy. Report results and the analysis of the literature shows that the technique of cholecystectomy by minilaparotomy is a valid option to laparoscopic cholecystectomy a...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The link between blood viscosity, Ht and the onset of stroke is highlighted and reports in the literature are examined. On this basic, the paper proposes an experimental model of cerebral ischaemia in the rabbit as providing a better insight into this aspect which may be highly significant, particularly in the prevent...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1989-06-15 00:00:00
abstract::Gastrointestinal carcinoids are infrequent but at the same time hardly rare tumours. They are often chance findings but, as is clearly reported in the literature, their potential malignancy should not be overlooked. They are most commonly localised in the appendix. The authors describe two case reports of carcinoid tu...
journal_title:Minerva chirurgica
pub_type: 杂志文章,评审
doi:
更新日期:1993-03-15 00:00:00
abstract::Over the course of 12 years (1977-1989) 40 patients aged over 50 (mean age 67 years) with acute appendicitis (Group I) were admitted to and operated in the Department of Surgery at Casalpusterlengo Hospital. Diagnosis was always confirmed by pathological examination. The following data were taken into account: the int...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:The metastasis of laryngeal nerve lymph node is mostly found in the upper-and middle esophageal cancer, the ratio of esophageal length from the upper incisors to the position where the esophageal tumor began to appear as proven via endoscopy to the height (LH) is likely to affect the possibility of detection...
journal_title:Minerva chirurgica
pub_type: 杂志文章
doi:10.23736/S0026-4733.20.08246-2
更新日期:2020-08-01 00:00:00