当前位置： SCI文献检索 > MOLECULAR PHARMACEUTICS期刊下所有文献 > Influence of microemulsion-mucin interaction on the fate of microemulsions diffusing through pig gastric mucin solutions.

Influence of microemulsion-mucin interaction on the fate of microemulsions diffusing through pig gastric mucin solutions.

Abstract：

:Mucus layer, a selective diffusion barrier, has an important effect on the fate of drug delivery systems in the gastrointestinal tract. To study the fate of microemulsions in the mucus layer, four microemulsion formulations with different particle sizes and lipid compositions were prepared. The microemulsion-mucin interaction was demonstrated by the fluorescence resonance energy transfer (FRET) method. Moreover, the microemulsions were observed aggregated into micron-sized emulsions by laser confocal microscopy. We concluded the microemulsion-mucin interaction not only led to microemulsions closely adhered to mucins but also destroyed the structure of microemulsions. At last, the diffusion of blank microemulsions and microemulsion-carried drugs (resveratrol and hymecromone) through mucin solutions was determined by the fluorescence recovery after photobleaching (FRAP) method and the Franz diffusion cell method. The results demonstrated the diffusion of microemulsions was significantly hindered by mucin solutions. The particle size of microemulsions had a negligible effect on the diffusion coefficients. However, the type of lipid played an important role, which could form hydrophobic interactions with mucins. Interestingly, microemulsion-carried drugs with different core/shell locations seemed to suffer different fates in the mucin solutions. The drug incorporated in the oil core of microemulsions, resveratrol, was transported through the mucus layer by the carriers, while the drug incorporated in the surfactant shell of microemulsions, hymecromone, was separated from the carriers and diffused toward the epithelium in the form of free molecules.

journal_name

Mol Pharm

journal_title

Molecular pharmaceutics

authors

Zhang J,Lv Y,Wang B,Zhao S,Tan M,Lv G,Ma X

doi

10.1021/mp500475y

subject

Has Abstract

pub_date

2015-03-02 00:00:00

pages

695-705

issue

3

eissn

1543-8384

issn

1543-8392

journal_volume

12

pub_type

杂志文章

相关文献

MOLECULAR PHARMACEUTICS文献大全
  • Approaches to Understanding the Solution-State Organization of Spray-Dried Dispersion Feed Solutions and Its Translation to the Solid State.

    abstract：:It is well established that polymers adopt a range of conformations and solution-state organization in response to varying solution environments, although very little work has been done to understand how these effects might impact the physical stability and bioavailability of spray-dried amorphous dispersions (SDDs). ...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.0c00729

    authors： Defrese MK,Farmer MA,Long Y,Timmerman LR,Bae Y,Marsac PJ

    更新日期：2020-12-07 00:00:00

  • Transcriptional and Post-Transcriptional Regulation of Duodenal P-Glycoprotein and MRP2 in Healthy Human Subjects after Chronic Treatment with Rifampin and Carbamazepine.

    abstract：:To predict the outcome of intestinal drug transporter induction on pharmacokinetics, signaling of the DNA message along with messenger RNA (mRNA) transcription and protein translation leading to transporter function must be understood. We quantified the gene expression of PXR and CAR, gene expression and protein abund...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b00458

    authors： Brueck S,Bruckmueller H,Wegner D,Busch D,Martin P,Oswald S,Cascorbi I,Siegmund W

    更新日期：2019-09-03 00:00:00

  • EGFR-Targeted Nanobody Functionalized Polymeric Micelles Loaded with mTHPC for Selective Photodynamic Therapy.

    abstract：:meta-Tetra(hydroxyphenyl)chlorin (mTHPC) is one of the most potent second-generation photosensitizers, clinically used for photodynamic therapy (PDT) of head and neck squamous cell carcinomas. However, improvements are still required concerning its present formulation (i.e., Foscan, a solution of mTHPC in ethanol/prop...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b01280

    authors： Liu Y,Scrivano L,Peterson JD,Fens MHAM,Hernández IB,Mesquita B,Toraño JS,Hennink WE,van Nostrum CF,Oliveira S

    更新日期：2020-04-06 00:00:00

  • "Flexible-Acceptor" General Solubility Equation for beyond Rule of 5 Drugs.

    abstract：:This study describes a novel nonlinear variant of the well-known Yalkowsky general solubility equation (GSE). The modified equation can be trained with small molecules, mostly from the Lipinski Rule of 5 (Ro5) chemical space, to predict the intrinsic aqueous solubility, S0, of large molecules (MW > 800 Da) from beyond...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.0c00689

    authors： Avdeef A,Kansy M

    更新日期：2020-10-05 00:00:00

  • Luteolin Inhibits Hepatitis B Virus Replication through Extracellular Signal-Regulated Kinase-Mediated Down-Regulation of Hepatocyte Nuclear Factor 4α Expression.

    abstract：:Whether luteolin inhibits HBV replication has not been validated and the underlying mechanism of which has never been elucidated. In this study, we show that luteolin reduces HBV DNA replication in HepG2.2.15 cells. Luteolin effectively inhibited the expression of hepatocyte nuclear factor 4α (HNF4α) and its binding t...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00789

    authors： Bai L,Nong Y,Shi Y,Liu M,Yan L,Shang J,Huang F,Lin Y,Tang H

    更新日期：2016-02-01 00:00:00

  • Control of Liposomal Penetration into Three-Dimensional Multicellular Tumor Spheroids by Modulating Liposomal Membrane Rigidity.

    abstract：:Effective penetration of drug-carrying nanoparticles into solid tumors is a major challenge in cancer therapy. Exploration of the physicochemical properties of nanoparticles that affect penetration efficiency is required to achieve maximum therapeutic effects. Here, we used confocal laser scanning microscopy to evalua...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b00051

    authors： Takechi-Haraya Y,Goda Y,Sakai-Kato K

    更新日期：2017-06-05 00:00:00

  • Internalization of mRNA lipoplexes by dendritic cells.

    abstract：:Lipoplexes, composed of Lipofectamine and mRNA encoding HIV Gag protein, were shown to be internalized by dendritic cells (DCs) and promote antigen presentation to stimulate HIV-specific T cell responses. Using confocal microscopy, we showed that one-third of fluorescently labeled mRNA containing lipoplexes are coloca...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp3003336

    authors： De Haes W,Van Mol G,Merlin C,De Smedt SC,Vanham G,Rejman J

    更新日期：2012-10-01 00:00:00

  • cRGD Peptide-Conjugated Pyropheophorbide-a Photosensitizers for Tumor Targeting in Photodynamic Therapy.

    abstract：:Pyropheophorbide-a (Pyro) is a highly promising photosensitizer for tumor photodynamic therapy (PDT), although its very limited tumor-accumulation ability seriously restricts its clinical applications. A higher accumulation of photosensitizers is very important for the treatment of deeply seated and larger tumors. The...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b01064

    authors： Li W,Tan S,Xing Y,Liu Q,Li S,Chen Q,Yu M,Wang F,Hong Z

    更新日期：2018-04-02 00:00:00

  • Chemical and enzymatic stability of amino acid prodrugs containing methoxy, ethoxy and propylene glycol linkers.

    abstract：:We evaluated the chemical and enzymatic stabilities of prodrugs containing methoxy, ethoxy and propylene glycol linkers in order to find a suitable linker for prodrugs of carboxylic acids with amino acids. l-Valine and l-phenylalanine prodrugs of model compounds (benzoic acid and phenyl acetic acid) containing methoxy...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp900084v

    authors： Gupta D,Gupta SV,Lee KD,Amidon GL

    更新日期：2009-09-01 00:00:00

  • Rapid measurement of intracellular unbound drug concentrations.

    abstract：:Intracellular unbound drug concentrations determine affinity to targets in the cell interior. However, due to difficulties in measuring them, they are often overlooked in pharmacology. Here we present a simple experimental technique for the determination of unbound intracellular drug concentrations in cultured cells t...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp4000822

    authors： Mateus A,Matsson P,Artursson P

    更新日期：2013-06-03 00:00:00

  • Mechanistic studies of a novel mycophenolic acid-glucosamine conjugate that attenuates renal ischemia/reperfusion injury in rat.

    abstract：:Renal ischemia/reperfusion (I/R) injury causes high mortality and morbidity during renal procedures, yet current drugs should be used at high doses or for long periods due to lack of tissue specificity. In previous work we described a novel mycophenolic acid-glucosamine conjugate (MGC) that targets the proximal tubule...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp500282g

    authors： Wang X,Xiong M,Zeng Y,Sun X,Gong T,Zhang Z

    更新日期：2014-10-06 00:00:00

  • Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: insights from coarse-grained simulations.

    abstract：:Therapeutic monoclonal antibody (mAb) candidates that form highly viscous solutions at concentrations above 100 mg/mL can lead to challenges in bioprocessing, formulation development, and subcutaneous drug delivery. Earlier studies of mAbs with concentration-dependent high viscosity have indicated that mAbs with negat...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp500485w

    authors： Buck PM,Chaudhri A,Kumar S,Singh SK

    更新日期：2015-01-05 00:00:00

  • Co-administration of dual-targeting nanoparticles with penetration enhancement peptide for antiglioblastoma therapy.

    abstract：:Chemotherapy is an indispensable auxiliary treatment for glioma but highly limited by the existence of both blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). The dysfunctional brain tumor blood vessels and high interstitial pressure in glioma also greatly hindered the accumulation and deep penetration of...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp400189j

    authors： Miao D,Jiang M,Liu Z,Gu G,Hu Q,Kang T,Song Q,Yao L,Li W,Gao X,Sun M,Chen J

    更新日期：2014-01-06 00:00:00

  • Enabling the intestinal absorption of highly polar antiviral agents: ion-pair facilitated membrane permeation of zanamivir heptyl ester and guanidino oseltamivir.

    abstract：:Antiviral drugs often suffer from poor intestinal permeability, preventing their delivery via the oral route. The goal of this work was to enhance the intestinal absorption of the low-permeability antiviral agents zanamivir heptyl ester (ZHE) and guanidino oseltamivir (GO) utilizing an ion-pairing approach, as a criti...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp100050d

    authors： Miller JM,Dahan A,Gupta D,Varghese S,Amidon GL

    更新日期：2010-08-02 00:00:00

  • Reduced skin photosensitivity with meta-tetra(hydroxyphenyl)chlorin-loaded micelles based on a poly(2-ethyl-2-oxazoline)-b-poly(d,l-lactide) diblock copolymer in vivo.

    abstract：:Photodynamic therapy (PDT) is a light-induced chemical reaction that produces localized tissue damage for the treatment of cancers and other nonmalignant conditions. The activation of photosensitizers in a target tissue is accomplished with a specific light source in the presence of molecular oxygen. In the clinic, pa...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp100060v

    authors： Shieh MJ,Peng CL,Chiang WL,Wang CH,Hsu CY,Wang SJ,Lai PS

    更新日期：2010-08-02 00:00:00

  • Targeting of injectable drug nanocrystals.

    abstract：:"Nano" drug delivery carriers are established technologies for improving the therapeutic index of chemotherapeutic drugs and overcoming formulation challenges of poorly water-soluble compounds. Two important remaining challenges, however, are the need to formulate drugs on a case-by-case basis (due to the specific che...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1021/mp5001247

    authors： Fuhrmann K,Gauthier MA,Leroux JC

    更新日期：2014-06-02 00:00:00

  • In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research.

    abstract：:Folate receptor (FR) targeting is an attractive strategy for nuclear imaging of cancer and activated macrophages through application of folic acid radioconjugates. However, significant renal accumulation of folate radioconjugates and hence exceedingly high emission of radiation from the kidneys may mask uptake of radi...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp300428p

    authors： Müller C,Reber J,Schlup C,Leamon CP,Schibli R

    更新日期：2013-03-04 00:00:00

  • Investigation of Within-Tablet Dynamics for Extended Release of a Poorly Soluble Basic Drug from Hydrophilic Matrix Tablets Using ATR-FTIR Imaging.

    abstract：:Hydrophilic matrices are an effective option for oral controlled release but can face challenges in terms of bioavailability and efficacy when used in conjunction with poorly soluble, weakly basic drugs. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) imaging provides dynamic information relating to...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b01063

    authors： Zahoor FD,Mader KT,Timmins P,Brown J,Sammon C

    更新日期：2020-04-06 00:00:00

  • PCPP-Adjuvanted Respiratory Syncytial Virus (RSV) sF Subunit Vaccine: Self-Assembled Supramolecular Complexes Enable Enhanced Immunogenicity and Protection.

    abstract：:PCPP, a well-defined polyphosphazene macromolecule, has been studied as an immunoadjuvant for a soluble form of the postfusion glycoprotein of respiratory syncytial virus (RSV sF), which is an attractive vaccine candidate for inducing RSV-specific immunity in mice and humans. We demonstrate that RSV sF-PCPP formulatio...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b00118

    authors： Cayatte C,Marin A,Rajani GM,Schneider-Ohrum K,Snell Bennett A,Marshall JD,Andrianov AK

    更新日期：2017-07-03 00:00:00

  • A cancer-specific variant of the SLCO1B3 gene encodes a novel human organic anion transporting polypeptide 1B3 (OATP1B3) localized mainly in the cytoplasm of colon and pancreatic cancer cells.

    abstract：:OATP1B3 is a member of the OATP (organic anion transporting polypeptides) superfamily, responsible for mediating the transport of numerous endogenous and xenobiotic substances. Although initially reported to be exclusively expressed in the liver, several studies reported that OATP1B3 is frequently expressed in multipl...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp3005353

    authors： Thakkar N,Kim K,Jang ER,Han S,Kim K,Kim D,Merchant N,Lockhart AC,Lee W

    更新日期：2013-01-07 00:00:00

  • "Smart" Nanoparticles Enhance the Cytoplasmic Delivery of Anti-RhoC Silencing RNA and Inhibit the Migration and Invasion of Aggressive Breast Cancer Cells.

    abstract：:Rho-GTPases are small GTP-binding proteins that contribute to the epithelial-to-mesenchymal transition by regulating several cellular processes including organization of the actin cytoskeleton, cell motility, transcription, and cell proliferation. Overexpression of RhoC-GTPases (RhoC) in breast cancer has been implica...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00114

    authors： Kaushal N,Durmaz YY,Bao L,Merajver SD,ElSayed ME

    更新日期：2015-07-06 00:00:00

  • In Vitro-in Vivo Correlation of Mucoadhesion Studies on Buccal Mucosa.

    abstract：BACKGROUND:For the development of novel buccoadhesive formulations, their physicochemical properties, strength of the interfacial joint, and residence time on the buccal mucosa are considered as a measure for their in vivo mucoadhesive properties. Focusing on these parameters, the predictive power of established in vit...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b00254

    authors： Baus RA,Haug MF,Leichner C,Jelkmann M,Bernkop-Schnürch A

    更新日期：2019-06-03 00:00:00

  • Biocompatible Reduction and pH Dual-Responsive Core Cross-Linked Micelles Based on Multifunctional Amphiphilic Linear-Hyperbranched Copolymer for Controlled Anticancer Drug Delivery.

    abstract：:Novel strategy has been developed for fabricating the biocompatible reduction and pH dual-responsive core cross-linked (CCL) micelles as drug delivery system (DDS) for the controlled anticancer drug delivery, via the atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) with N,N'-bis(acryloyl)cystam...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.6b01051

    authors： Tian K,Jia X,Zhao X,Liu P

    更新日期：2017-03-06 00:00:00

  • Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.

    abstract：:Within the immune system there is an exquisite ability to discriminate between "self" and "non-self" that is orchestrated by antigen-specific T lymphocytes. Genomic plasticity enables differentiation of naive CD4+ T lymphocytes into either regulatory cells (Treg) that express the transcription factor Foxp3 and activel...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp100203a

    authors： Park J,Gao W,Whiston R,Strom TB,Metcalfe S,Fahmy TM

    更新日期：2011-02-07 00:00:00

  • Formation of Indomethacin-Saccharin Cocrystals during Wet Granulation: Role of Polymeric Excipients.

    abstract：:Formulation of a cocrystal into a solid pharmaceutical dosage form entails numerous processing steps during which there is risk of dissociation. In an effort to reduce the number of unit operations, we have attempted the in situ formation of an indomethacin-saccharin (INDSAC) cocrystal during high-shear wet granulatio...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b01004

    authors： Tanaka R,Duggirala NK,Hattori Y,Otsuka M,Suryanarayanan R

    更新日期：2020-01-06 00:00:00

  • Mechanism for enhanced absorption of a solid dispersion formulation of LY2300559 using the artificial stomach duodenum model.

    abstract：:An artificial stomach duodenum (ASD) model has been used to demonstrate the performance difference between two formulations of LY2300559, a low-solubility acidic developmental drug. The two formulations investigated were a conventional high-shear wet granulation (HSWG) formulation and a solid dispersion formulation. A...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp5006036

    authors： Polster CS,Wu SJ,Gueorguieva I,Sperry DC

    更新日期：2015-04-06 00:00:00

  • Cationic phospholipids forming cubic phases: lipoplex structure and transfection efficiency.

    abstract：:The transfection activity and the phase behavior of two novel cationic O-alkyl-phosphatidylcholines, 1,2-dioleoyl- sn-glycero-3-hexylphosphocholine (C6-DOPC) and 1,2-dierucoyl- sn-glycero-3-ethylphosphocholine (di22:1-EPC), have been examined with the aim of more completely understanding the mechanism of lipid-mediate...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp800011e

    authors： Koynova R,Wang L,Macdonald RC

    更新日期：2008-09-01 00:00:00

  • Delivery of polysaccharides using polymer particles: implications on size-dependent immunogenicity, opsonophagocytosis, and protective immunity.

    abstract：:Bacterial capsular polysaccharides are components of many modern vaccines, but they are weakly immunogenic. Herein, we describe the delivery of pneumococcal capsular polysaccharide serotype-1 (PCP-1) in polylactide polymeric particles to enhance its immunogenicity. Immunization with PCP-1-entrapped particles elicited ...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp400589q

    authors： Anish C,Khan N,Upadhyay AK,Sehgal D,Panda AK

    更新日期：2014-03-03 00:00:00

  • Engineered Human Adipose Stem-Cell-Derived Exosomes Loaded with miR-21-5p to Promote Diabetic Cutaneous Wound Healing.

    abstract：:Diabetic wounds are a worldwide health problem causing extremely heavy public health burden and require effective treatment. Optimal strategies for treating nonhealing diabetic wounds include stem-cell-based therapy and delivery of novel drug substances, such as functional microRNAs (miRNAs); however, miRNA easily deg...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.0c00177

    authors： Lv Q,Deng J,Chen Y,Wang Y,Liu B,Liu J

    更新日期：2020-05-04 00:00:00

  • Evaluating the in vitro inhibition of UGT1A1, OATP1B1, OATP1B3, MRP2, and BSEP in predicting drug-induced hyperbilirubinemia.

    abstract：:Hyperbilirubinemia may arise due to inadequate clearance of bilirubin from the body. Bilirubin elimination is a multifaceted process consisting of uptake of bilirubin into the hepatocytes facilitated by OATP1B1 and OATP1B3. Once in the hepatocytes, it is extensively glucuronidated by UGT1A1. Eventually, the glucuronid...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp4001348

    authors： Chang JH,Plise E,Cheong J,Ho Q,Lin M

    更新日期：2013-08-05 00:00:00