当前位置： SCI文献检索 > MOLECULAR PHARMACEUTICS期刊下所有文献 > Mechanistic studies of a novel mycophenolic acid-glucosamine conjugate that attenuates renal ischemia/reperfusion injury in rat.

Mechanistic studies of a novel mycophenolic acid-glucosamine conjugate that attenuates renal ischemia/reperfusion injury in rat.

Abstract：

:Renal ischemia/reperfusion (I/R) injury causes high mortality and morbidity during renal procedures, yet current drugs should be used at high doses or for long periods due to lack of tissue specificity. In previous work we described a novel mycophenolic acid-glucosamine conjugate (MGC) that targets the proximal tubule epithelium, where it efficiently reduces renal I/R injury in rats and promotes recovery from reperfusion. Here we perform mechanistic studies of MGC in rats that suggest that the conjugate works by repressing the activation of renal inosine-5'-monophosphate dehydrogenase 2 (IMPDH2), thereby inhibiting the proliferation and accumulation of lympholeukocytes in the proximal tubules. In addition, MGC appears to inhibit inflammation through various pathways, including inhibition of free oxygen radical production, upregulation of bone morphogenetic protein-7, and downregulation of complement protein 3, TLR 4, intracellular adhesion molecules in the endothelium, proinflammatory cytokines (e.g., TNF-α, IL-6, IL-1, TGF-β), and chemotactic cytokines [e.g., monocyte chemoattractant protein-1 (MCP-1) and IL-8]. These findings suggest that MGC specifically targets the proximal tubules and acts through numerous mechanisms to substantially mitigate I/R injury in rats; this conjugate may provide a more effective alternative to current combination therapy.

journal_name

Mol Pharm

journal_title

Molecular pharmaceutics

authors

Wang X,Xiong M,Zeng Y,Sun X,Gong T,Zhang Z

doi

10.1021/mp500282g

subject

Has Abstract

pub_date

2014-10-06 00:00:00

pages

3503-14

issue

10

eissn

1543-8384

issn

1543-8392

journal_volume

11

pub_type

杂志文章

相关文献

MOLECULAR PHARMACEUTICS文献大全
  • Selectin ligands promote ultrasound contrast agent adhesion under shear flow.

    abstract：:Contrast-enhanced ultrasound imaging has shown promise in the field of molecular imaging. This technique relies upon the adhesion of ultrasound contrast agent (UCA) to targeted molecular markers of disease. This is accomplished by coating the surface of the contrast agent with a ligand that specifically binds to the i...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp0600541

    authors： Rychak JJ,Li B,Acton ST,Leppänen A,Cummings RD,Ley K,Klibanov AL

    更新日期：2006-09-01 00:00:00

  • Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

    abstract：:This study determined intraluminal ethanol concentrations (stomach and duodenum) in fed healthy volunteers after the consumption of common alcoholic beverages (beer, wine, and whisky). The results of this study were compared with a previous study in fasted volunteers. Five healthy volunteers were recruited in a crosso...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b00252

    authors： Rubbens J,Riethorst D,Brouwers J,Wolfs K,Adams E,Tack J,Augustijns P

    更新日期：2017-12-04 00:00:00

  • Receptor-mediated, tumor-targeted gene delivery using folate-terminated polyrotaxanes.

    abstract：:Safe and effective gene delivery is essential to the success of gene therapy. We synthesized and characterized a novel nonviral gene delivery system in which folate (FA) molecules were functioned as blockers on cationic polyrotaxanes (PR) composed of poly(ethylenimine) (PEI)(600)-grafted α-cyclodextrin rings linearize...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp200315c

    authors： Zhou Y,Wang H,Wang C,Li Y,Lu W,Chen S,Luo J,Jiang Y,Chen J

    更新日期：2012-05-07 00:00:00

  • A steroid-conjugated magnetic resonance probe enhances contrast in progesterone receptor expressing organs and tumors in vivo.

    abstract：:Progesterone receptor (PR) is a significant biomarker in diseases such as endometriosis and breast, ovarian, and uterine cancers that is associated with disease prognosis and therapeutic efficacy. While receptor status is currently determined by immunohistochemistry assays, the development of noninvasive PR imaging ag...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp200219e

    authors： Sukerkar PA,MacRenaris KW,Meade TJ,Burdette JE

    更新日期：2011-08-01 00:00:00

  • Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function.

    abstract：:This research determined the uptake of individual components of topically applied microemulsions into the stratum corneum (SC) and assessed their molecular effects on skin barrier function. The microemulsions comprised oleic acid, Tween20, Transcutol and water. The effects of selected formulations, and of the individu...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp100068s

    authors： Hathout RM,Mansour S,Mortada ND,Geneidi AS,Guy RH

    更新日期：2010-08-02 00:00:00

  • Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles.

    abstract：:In the current study, nanoparticles containing the antimetabolite drug methotrexate (MTX) and the novel tubulin-binding drug pretubulysin (PT) were developed for combination chemotherapy. Polyelectrolyte complexes were formed based on ∼20 nm cationic nanomicelles of lipo-oligomer 454 with the anionic MTX at the molar ...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b00038

    authors： Truebenbach I,Kern S,Loy DM,Höhn M,Gorges J,Kazmaier U,Wagner E

    更新日期：2019-06-03 00:00:00

  • Liquid-Liquid Phase Separation in a Dual Variable Domain Immunoglobulin Protein Solution: Effect of Formulation Factors and Protein-Protein Interactions.

    abstract：:Dual variable domain immunoglobulin proteins (DVD-Ig proteins) are large molecules (MW ∼ 200 kDa) with increased asymmetry because of their extended Y-like shape, which results in increased formulation challenges. Liquid-liquid phase separation (LLPS) of protein solutions into protein-rich and protein-poor phases redu...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00256

    authors： Raut AS,Kalonia DS

    更新日期：2015-09-08 00:00:00

  • Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention.

    abstract：:We studied the molecular mechanism of greater efficacy of paclitaxel-loaded nanoparticles (Tx-NPs) following conjugation to transferrin (Tf) ligand in breast cancer cell line. NPs were formulated using biodegradable polymer, poly(lactic-co-glycolide) (PLGA), with encapsulated Tx and conjugated to Tf ligand via an epox...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp050032z

    authors： Sahoo SK,Labhasetwar V

    更新日期：2005-09-01 00:00:00

  • Deep Convolutional Generative Adversarial Network (dcGAN) Models for Screening and Design of Small Molecules Targeting Cannabinoid Receptors.

    abstract：:A deep convolutional generative adversarial network (dcGAN) model was developed in this study to screen and design target-specific novel compounds for cannabinoid receptors. In the adversarial process of training, two models, the discriminator D and the generator G, are iteratively trained. D is trained to discover th...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.9b00500

    authors： Bian Y,Wang J,Jun JJ,Xie XQ

    更新日期：2019-11-04 00:00:00

  • Influence of microemulsion-mucin interaction on the fate of microemulsions diffusing through pig gastric mucin solutions.

    abstract：:Mucus layer, a selective diffusion barrier, has an important effect on the fate of drug delivery systems in the gastrointestinal tract. To study the fate of microemulsions in the mucus layer, four microemulsion formulations with different particle sizes and lipid compositions were prepared. The microemulsion-mucin int...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp500475y

    authors： Zhang J,Lv Y,Wang B,Zhao S,Tan M,Lv G,Ma X

    更新日期：2015-03-02 00:00:00

  • Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection.

    abstract：:The primary cause of mortality for glioblastoma (GBM) is local tumor recurrence following standard-of-care therapies, including surgical resection. With most tumors recurring near the site of surgical resection, local delivery of chemotherapy at the time of surgery is a promising strategy. Herein drug-loaded polymer s...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b01114

    authors： Graham-Gurysh E,Moore KM,Satterlee AB,Sheets KT,Lin FC,Bachelder EM,Miller CR,Hingtgen SD,Ainslie KM

    更新日期：2018-03-05 00:00:00

  • Predicting the Agitation-Induced Aggregation of Monoclonal Antibodies Using Surface Tensiometry.

    abstract：:Adsorption of antibody therapeutics to air-liquid interfaces can enhance aggregation, particularly when the solution does not contain protective surfactant or when the surfactant is diluted as occurs during preparation of intravenous infusion bags. The ability to predict an antibody's propensity for interfacially medi...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00089

    authors： Shieh IC,Patel AR

    更新日期：2015-09-08 00:00:00

  • Positively Charged Surface-Modified Solid Lipid Nanoparticles Promote the Intestinal Transport of Docetaxel through Multifunctional Mechanisms in Rats.

    abstract：:Solid lipid nanoparticles (SLNs) are one of the most promising nanocarriers to increase the oral absorption of drugs with poor solubility and low permeability. However, the absorption mechanism of SLNs remains incomplete and thus requires further careful consideration. In this study, positively charged chitosan (CS) m...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.6b00226

    authors： Shi LL,Xie H,Lu J,Cao Y,Liu JY,Zhang XX,Zhang H,Cui JH,Cao QR

    更新日期：2016-08-01 00:00:00

  • Dispersion of cisplatin-loaded carbon nanohorns with a conjugate comprised of an artificial peptide aptamer and polyethylene glycol.

    abstract：:Hydrophobic single-wall carbon nanohorns (SWNHs) were dispersed in aqueous media by noncovalently modifying their surfaces with conjugate molecules comprised of polyethylene glycol (PEG) and a peptide aptamer (NHBP-1) that specifically bind to the surfaces of the SWNHs. The conjugates were synthesized by coupling PEG ...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp070022t

    authors： Matsumura S,Ajima K,Yudasaka M,Iijima S,Shiba K

    更新日期：2007-09-01 00:00:00

  • Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.

    abstract：:Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic uptake of various drugs. Because OATP1B1 is a site of drug-drug interactions (DDIs), evaluating the inhibitory potential of drug candidates on OATP1B1 is required during drug development. For establishing a highly sensitive, high-...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00664

    authors： Izumi S,Nozaki Y,Komori T,Takenaka O,Maeda K,Kusuhara H,Sugiyama Y

    更新日期：2016-02-01 00:00:00

  • Synthesis, characterization, and gene delivery of poly-L-lysine octa(3-aminopropyl)silsesquioxane dendrimers: nanoglobular drug carriers with precisely defined molecular architectures.

    abstract：:Macromolecules with defined nanosizes--nanoglobules--were synthesized and characterized as novel drug carriers with precise molecular architectures. Poly-L-lysine dendrimers with a cubic octa(3-aminopropyl)silsesquioxane (OAS) core, (L-lysine 8-OAS, (L-lysine) 16-(L-lysine) 8-OAS, (L-lysine) 32-(L-lysine) 16-(L-lysine...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp070036z

    authors： Kaneshiro TL,Wang X,Lu ZR

    更新日期：2007-09-01 00:00:00

  • Selective Photokilling of Colorectal Tumors by Near-Infrared Photoimmunotherapy with a GPA33-Targeted Single-Chain Antibody Variable Fragment Conjugate.

    abstract：:Antibody-based near-infrared photoimmunotherapy (NIR-PIT) is an attractive strategy for cancer treatment. Tumor cells can be selectively and efficiently killed by the targeted delivery of an antibody-photoabsorber complex followed by exposure to NIR light. Glycoprotein A33 antigen (GPA33) is highly expressed in most h...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.0c00210

    authors： Wei D,Tao Z,Shi Q,Wang L,Liu L,She T,Yi Q,Wen X,Liu L,Li S,Yang H,Jiang X

    更新日期：2020-07-06 00:00:00

  • Intrinsic dynamics of DNA-polymer complexes: a mechanism for DNA release.

    abstract：:The transfer of genetic material into cells using nonviral vectors offers unique potential for therapeutics; however, the efficacy of delivery depends upon a poorly understood, multistep pathway, limiting the prospects for successful gene delivery. Mechanistic insight into DNA association and release has been hampered...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp3002864

    authors： Prevette LE,Nikolova EN,Al-Hashimi HM,Banaszak Holl MM

    更新日期：2012-09-04 00:00:00

  • Dissolution rate and apparent solubility of poorly soluble drugs in biorelevant dissolution media.

    abstract：:A series of poorly soluble BCS class II compounds with "grease ball" characteristics were assessed for solubility and dissolution rate in biorelevant dissolution media (BDM) with the purpose of investigating which molecular structures gain most in solubility when dissolved under physiologically relevant conditions. Th...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp100049m

    authors： Fagerberg JH,Tsinman O,Sun N,Tsinman K,Avdeef A,Bergström CA

    更新日期：2010-10-04 00:00:00

  • Active targeting of block copolymer micelles with trastuzumab Fab fragments and nuclear localization signal leads to increased tumor uptake and nuclear localization in HER2-overexpressing xenografts.

    abstract：:Block copolymer micelles (BCMs) have been employed as effective drug delivery systems to solid tumors by virtue of their capacity to transport large therapeutic payloads and passively target tumor sites. Active targeting of nanoparticles (NPs) has been exploited as a means to increase the therapeutic efficacy of NP-ba...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp400315p

    authors： Hoang B,Ekdawi SN,Reilly RM,Allen C

    更新日期：2013-11-04 00:00:00

  • Synthesis and Characterization of (89)Zr-Labeled Ultrasmall Nanoparticles.

    abstract：:The ultrasmall nanoparticle AGuIX is a versatile platform that tolerates a range of chemical diversity for theranostic applications. Our previous work showed that AGuIX clears rapidly from normal tissues, while durably accumulating within the tumor microenvironment. On this basis, AGuIX was used to detect tumor tissue...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.6b00264

    authors： Truillet C,Thomas E,Lux F,Huynh LT,Tillement O,Evans MJ

    更新日期：2016-07-05 00:00:00

  • Protein Delivery by Peptide-Based Stealth Liposomes: A Biomolecular Insight into Enzyme Replacement Therapy.

    abstract：:Infantile neural ceroid lipofuscinosis (INCL) is a lysosomal storage disorder characterized by mutations in the CLN1 gene that leads to lack of the lysosomal enzyme palmitoyl-protein thioesterase-1 (PPT1), which causes the progressive death of cortical neurons. Enzyme replacement therapy (ERT) is one of the most promi...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.0c00615

    authors： Santi M,Finamore F,Cecchettini A,Santorelli FM,Doccini S,Rocchiccioli S,Signore G

    更新日期：2020-12-07 00:00:00

  • Gastroretentive extended-release floating granules prepared using a novel fluidized hot melt granulation (FHMG) technique.

    abstract：:The objective of this work was to investigate the feasibility of using a novel granulation technique, namely, fluidized hot melt granulation (FHMG), to prepare gastroretentive extended-release floating granules. In this study we have utilized FHMG, a solvent free process in which granulation is achieved with the aid o...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp500242q

    authors： Zhai H,Jones DS,McCoy CP,Madi AM,Tian Y,Andrews GP

    更新日期：2014-10-06 00:00:00

  • Bacterial cellulose/acrylamide pH-sensitive smart hydrogel: development, characterization, and toxicity studies in ICR mice model.

    abstract：:The objective of this study is to synthesize and evaluate acute toxicity of the bacterial cellulose (BC)/acrylamide (Am) hydrogels as noncytotoxic and biocompatible oral drug delivery vehicles. A novel series of solubilized BC/Am hydrogels were synthesized using a microwave irradiation method. The hydrogels were chara...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp500337r

    authors： Pandey M,Mohamad N,Amin MC

    更新日期：2014-10-06 00:00:00

  • Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood-Brain Barrier.

    abstract：:The endothelial cells lining the capillaries supplying the brain with oxygen and nutrients form a formidable barrier known as the blood-brain barrier (BBB), which exhibits selective permeability to small drug molecules and virtually impermeable to macromolecular therapeutics. Current in vitro BBB models fail to replic...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.5b00805

    authors： Wang JD,Khafagy el-S,Khanafer K,Takayama S,ElSayed ME

    更新日期：2016-03-07 00:00:00

  • Normalizing Tumor Vessels To Increase the Enzyme-Induced Retention and Targeting of Gold Nanoparticle for Breast Cancer Imaging and Treatment.

    abstract：:Abnormal tumor vessels impede the transport and distribution of chemotherapeutics, resulting in low drug concentration at tumor sites and compromised drug efficacy. Normalizing tumor vessels can modulate tumor vascular permeability, alleviate tumor hypoxia, increase blood perfusion, attenuate interstitial fluid pressu...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.7b00475

    authors： Xiao W,Ruan S,Yu W,Wang R,Hu C,Liu R,Gao H

    更新日期：2017-10-02 00:00:00

  • PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: synergistic anticancer effect.

    abstract：:Selective ligands to the peripheral benzodiazepine receptor (PBR) may induce apoptosis and cell cycle arrest. An overexpression of PBR in certain cancers allowed us to consider the use of highly selective ligands to PBR for receptor-mediated drug targeting to tumors. With this in mind, we prepared PBR-targeted nanopar...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp800158c

    authors： Musacchio T,Laquintana V,Latrofa A,Trapani G,Torchilin VP

    更新日期：2009-03-01 00:00:00

  • Novel 99mTc-Labeled Glucose Derivative for Single Photon Emission Computed Tomography: A Promising Tumor Imaging Agent.

    abstract：:In this study, a d-glucosamine derivative with an isonitrile group (CN5DG) was synthesized and it was chosen to coordinate with 99mTc for preparing 99mTc-CN5DG. 99mTc-CN5DG could be readily obtained with high radiochemical purity (>95%) and had great in vitro stability and metabolic stability in urine. The radiotracer...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/acs.molpharmaceut.8b00415

    authors： Zhang X,Ruan Q,Duan X,Gan Q,Song X,Fang S,Lin X,Du J,Zhang J

    更新日期：2018-08-06 00:00:00

  • On the solubility and lipophilicity of metallacarborane pharmacophores.

    abstract：:Metallacarborane moieties have been identified as promising pharmacophores. The pharmaceutical use of such compounds is, however, complicated by their low solubility and tendency to self-assemble in aqueous solution. In this work, we estimated the solubilities of a vast series of metallacarboranes [cobalt bis(dicarbol...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp300565z

    authors： Rak J,Dejlová B,Lampová H,Kaplánek R,Matějíček P,Cígler P,Král V

    更新日期：2013-05-06 00:00:00

  • Pycup--a bifunctional, cage-like ligand for (64)Cu radiolabeling.

    abstract：:In developing targeted probes for positron emission tomography (PET) based on (64)Cu, stable complexation of the radiometal is key, and a flexible handle for bioconjugation is highly advantageous. Here, we present the synthesis and characterization of the chelator pycup and four derivatives. Pycup is a cross-bridged c...

    journal_title：Molecular pharmaceutics

    pub_type： 杂志文章

    doi：10.1021/mp400686z

    authors： Boros E,Rybak-Akimova E,Holland JP,Rietz T,Rotile N,Blasi F,Day H,Latifi R,Caravan P

    更新日期：2014-02-03 00:00:00